フククラ　ヨシヒコ   Yoshihiko Fukukura   福倉　良彦    所属   川崎医科大学  医学部 臨床医学　機能・代謝画像診断学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Uterine cervical carcinomas associated with lobular endocervical glandular hyperplasia.
掲載誌名	正式名：Histopathology 略　 称：Histopathology ISSNコード：13652559/03090167
掲載区分	国外
巻・号・頁	59(1),pp.55-62
著者・共著者	Takahiro Tsuji, Shinichi Togami, Mitsuharu Nomoto, Michiyo Higashi, Yoshihiko Fukukura, Masaki Kamio, Suguru Yonezawa, Tsutomu Douchi
発行年月	2011/07
概要	AIMS:To investigate the clinicopathological features of cervical uterine carcinoma associated with lobular endocervical glandular hyperplasia (LEGH).METHODS AND RESULTS:Subjects comprised 12 patients with cervical carcinoma associated with LEGH. Carcinoma included nine invasive adenocarcinomas, two adenocarcinoma in-situ (AIS) and one microinvasive squamous cell carcinoma (SCC). Baseline characteristics, cervical cytology, human papilloma virus (HPV) status, immunohistochemistry, surgical procedures and clinical outcomes were investigated. There was a pair of adenocarcinoma cases in a mother and daughter unrelated to Peutz-Jeghers syndrome. In all patients, atypical cells were seen on cervical cytology (adenocarcinoma cells in 11 cases and SCC cells in one). All the 12 patients were positive for mucin antigen 6 (MUC6) in the LEGH component, while seven patients were positive for gastric mucin (HIK1083). HPV was detected only in the SCC component. One patient with adenocarcinoma stage Ib died of disease 4 years after radical hysterectomy. The others are currently alive 2-16 years postoperatively.CONCLUSIONS:The diagnosis of adenocarcinoma with LEGH is not always difficult. The prognosis of adenocarcinoma associated with LEGH may be better than previously expected. Adenocarcinoma with a LEGH component does not always develop into a highly aggressive minimal deviation adenocarcinoma.
DOI	10.1111/j.1365-2559.2011.03886.x
PMID	21771026