フククラ　ヨシヒコ   Yoshihiko Fukukura   福倉　良彦    所属   川崎医科大学  医学部 臨床医学　機能・代謝画像診断学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Pancreatic adenocarcinoma: analysis of the effect of various concentrations of contrast material.
掲載誌名	正式名：Radiation medicine 略　 称：Radiat Med ISSNコード：02882043/02882043
掲載区分	国外
巻・号・頁	26(6),pp.355-361
著者・共著者	Yoshihiko Fukukura, Hiroyuki Hamada, Takuro Kamiyama, Tomohide Yoneyama, Koji Takumi, Masayuki Nakajo
発行年月	2008/07
概要	PURPOSE:The aim of this study was to compare the efficacy of two contrast materials with moderate and high iodine concentrations for the depiction of pancreatic adenocarcinoma.MATERIALS AND METHODS:A series of 107 patients with histologically proven pancreatic adenocarcinoma underwent helical computed tomography. A fixed dose of 100 ml of iopamidol 300 (mg I/ml) was administered to 50 patients (group A) and iopamidol 370 (mg I/ml) to 57 patients (group B) at the same injection rate (3 ml/s). Unenhanced helical scans and contrast-enhanced scans for three phases (30, 70, and 300 s after starting the infusion of contrast material) were obtained. We evaluated enhancement of the aorta, portal vein, hepatic parenchyma, pancreatic parenchyma, and pancreatic adenocarcinoma during each phase.RESULTS:During all phases, both aortic and pancreatic enhancement were significantly greater in group B than in group A (P<0.01). Enhancement of the portal vein and hepatic parenchyma was significantly greater at 70 and 300 s in group B than in group A (both P<0.01). Tumor-to-pancreas contrast was significantly greater in group B than in group A at both 30 s (P<0.01) and 70 s (P<0.05).CONCLUSION:Administration of contrast material with a high iodine concentration is more effective for depicting pancreatic adenocarcinomas.
DOI	10.1007/s11604-008-0240-0
PMID	18677610