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イワモト タカユキ
Takayuki Iwamoto
岩本 高行 所属 川崎医科大学 医学部 臨床医学 乳腺甲状腺外科学 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognostic significance of the Ki67 scoring categories in breast cancer subgroups. |
| 掲載誌名 | 正式名：Clinical breast cancer 略 称：Clin Breast Cancer ISSNコード：19380666/15268209 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 14(5),pp.323-329.e3 |
| 著者・共著者 | Naoki Niikura, Shinobu Masuda, Nobue Kumaki, Tang Xiaoyan, Mizuho Terada, Mayako Terao, Takayuki Iwamoto, Risa Oshitanai, Toru Morioka, Banri Tuda, Takuho Okamura, Yuki Saito, Yasuhiro Suzuki, Yutaka Tokuda |
| 発行年月 | 2014/10 |
| 概要 | BACKGROUND:Immunohistochemical (IHC) expression of Ki67 has a prognostic and predictive value for breast cancer, and the IHC Ki67 labeling index is estimated by counting the number of positive and negative cells. It has not been clarified whether IHC Ki67 estimated using a semiquantitative scoring system has a prognostic value. We aimed to estimate the usefulness of scoring categories of IHC Ki67 as a prognostic factor for breast cancer subgroups.PATIENTS AND METHODS:We retrospectively identified patients in the Tokai University breast cancer database for whom IHC Ki67 data were available between January 1, 2000 and December 31, 2010. Survival curves were calculated using the Kaplan-Meier method and compared using the log-rank test.RESULTS:Of the 1331 primary breast cancer patients included in the study, In patients with estrogen receptor (ER)-positive and HER2-negative tumors (n = 971), high and intermediate Ki67 scores were associated with poorer relapse-free survival than low Ki67 scores (P < .001 and P = .002, respectively). Furthermore, in the multivariate analyses of this subgroup, progression-free survival (PFS) was significantly longer in patients with low Ki67 scores than in patients with high Ki67 scores (hazard ratio, 0.387; 95% confidence interval, 0.233-0.643; P < .001). In the multivariate analyses, the Ki67 score was not significantly associated with PFS in the ER-positive and HER2-positive, ER-negative and HER2-positive, or ER-negative and HER2-negative subgroups.CONCLUSION:Our data demonstrated that low, intermediate, and high Ki67 scores have a prognostic value in breast cancer patients with ER-positive and HER2-negative tumors. |
| DOI | 10.1016/j.clbc.2013.12.013 |
| PMID | 24492237 |