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イワモト タカユキ
Takayuki Iwamoto
岩本 高行 所属 川崎医科大学 医学部 臨床医学 乳腺甲状腺外科学 職種 講師 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. |
| 掲載誌名 | 正式名：Breast cancer research : BCR 略 称：Breast Cancer Res ISSNコード：1465542X/14655411 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 15(6),pp.R112 |
| 著者・共著者 | Hiroko Masuda, Keith A Baggerly, Ying Wang, Takayuki Iwamoto, Takae Brewer, Lajos Pusztai, Kazuharu Kai, Takahiro Kogawa, Pascal Finetti, Daniel Birnbaum, Luc Dirix, Wendy A Woodward, James M Reuben, Savitri Krishnamurthy, W Symmans, Steven J Van Laere, François Bertucci, Gabriel N Hortobagyi, Naoto T Ueno |
| 発行年月 | 2013/11 |
| 概要 | INTRODUCTION:Because of its high rate of metastasis, inflammatory breast cancer (IBC) has a poor prognosis compared with non-inflammatory types of breast cancer (non-IBC). In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer (TNBC). We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.METHODS:We determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known (39 cases of TN-IBC; 49 cases of TN-non-IBC). We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.RESULTS:We found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status (P = 0.47). TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.CONCLUSIONS:Our data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC. |
| DOI | 10.1186/bcr3579 |
| PMID | 24274653 |