アラキ　シュンスケ   Syunsuke Araki   荒木　俊介    所属   川崎医療福祉大学  リハビリテーション学部 視能療法学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Evaluation of Significance Maps and the Analysis of the Longitudinal Time Course of the Macular Ganglion Cell Complex Thicknesses in Acquired Occipital Homonymous Hemianopia Using Spectral-domain Optical Coherence Tomography.
掲載誌名	正式名：Neuro-ophthalmology (Aeolus Press) 略　 称：Neuroophthalmology ISSNコード：01658107/01658107
掲載区分	国外
巻・号・頁	44(4),pp.236-245
著者・共著者	Tsutomu Yamashita, Atsushi Miki, Katsutoshi Goto, Syunsuke Araki, Go Takizawa, Yoshiaki Ieki, Junichi Kiryu, Akio Tabuchi, Yasuyuki Iguchi, Kazumi Kimura, Yoshiki Yagita
発行年月	2020
概要	The present study was performed to evaluate the ganglion cell complex (GCC) thickness as well as the significance map and analyse the time course of the change in GCC thickness in patients with homonymous hemianopia due to posterior cerebral artery (PCA) territory stroke using spectral-domain optical coherence tomography. This study included 40 control subjects and 11 patients with unilateral PCA territory stroke. The GCC parameters were quantified using a custom-built software programme. The GCC data, centred on the macula, was divided vertically into hemianopic and unaffected sides. GCC parameters were calculated using an average of those from both eyes. The relationship between the GCC parameters and the time after stroke was determined by regression analyses. The GCC parameters in the hemi-retinae corresponding to the affected hemifields significantly differed between the hemianopes and the control group. The area under the receiver operating characteristics curve of the GCC significance map areas was significantly high. A regression analysis revealed a significant relationship between the time after stroke and both the GCC significance map areas (r = 0.791, p = .004) and GCC thickness (r = -0.736, p = .010) on the hemianopic side. The GCC parameters on the hemianopic side were reduced in patients with acquired occipital homonymous hemianopia, and the reduction was slowly progressive probably due to transsynaptic retrograde degeneration of the retinal ganglion cells. A significance map analysis provides additional OCT parameters that could be used to investigate the effect of retrogeniculate lesions on the inner retina of patients.
DOI	10.1080/01658107.2019.1686764
PMID	33012909