|
ドイハラ ヒロヨシ
Hiroyoshi Doihara
土井原 博義 所属 川崎医科大学 医学部 臨床医学 総合外科学 職種 特任教授 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments. |
| 掲載誌名 | 正式名：Breast cancer research and treatment 略 称：Breast Cancer Res Treat ISSNコード：15737217/01676806 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 185(2),pp.307-316 |
| 著者・共著者 | Hatono Minami, Ikeda Hirokuni, Suzuki Yoko, Kajiwara Yukiko, Kawada Kengo, Tsukioki Takahiro, Kochi Mariko, Suzawa Ken, Iwamoto Takayuki, Yamamoto Hiromasa, Shien Tadahiko, Yamane Masaomi, Taira Naruto, Doihara Hiroyoshi, Toyooka Shinichi |
| 発行年月 | 2021/01 |
| 概要 | PURPOSE:Epidemiological studies have suggested that intake of soy isoflavones is associated with a reduced risk of development of breast cancer and an improved prognosis in patients with breast cancer. In addition, basic research has demonstrated the antitumor effects of these compounds on breast cancer cell lines. However, the detailed effects of the intake of equol, which is one of the metabolites of the soy isoflavones, are yet to be clarified on the risk of development and recurrence of breast cancer and its interactions with drugs used for treating breast cancer. This study aimed to determine the antitumor effects of equol and investigate the impact of adding equol to therapeutic agents for breast cancer using breast cancer cell lines.METHODS:We examined the antitumor effect of equol on breast cancer cell lines using MTS assay. We also studied the combined effect of equol and the existing hormonal or chemotherapeutic agents using combination index. We evaluated the expressions of the related proteins by Western blot analysis and correlated the findings with the antitumor effect.RESULTS:Equol showed bi-phasic protumor and antitumor effects; at a low concentration, it promoted the tumor growth in hormone receptor-positive cell lines, whereas antitumor effects were generally observed when an excessive amount of dose unexpected in the blood and the tissue was administered. When used with tamoxifen, equol might have some antagonistic effect, although it depends on equol concentration and the type of cancer cells.CONCLUSIONS:We confirmed that equol has dual action, specifically a tumor growth-promoting effect and an antitumor effect. Although the results suggested that equol might exert an antagonistic effect against tamoxifen depending on the concentration, equol did not exert an antagonistic effect on other therapeutic agents. |
| DOI | 10.1007/s10549-020-05957-z |
| PMID | 33034801 |