ドイハラ　ヒロヨシ   Hiroyoshi Doihara   土井原　博義    所属   川崎医科大学  医学部 臨床医学　総合外科学    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Recurring radiation-induced angiosarcoma of the breast that was treated with paclitaxel chemotherapy: a case report.
掲載誌名	正式名：Surgical case reports 略　 称：Surg Case Rep ISSNコード：21987793/21987793
掲載区分	国外
巻・号・頁	6(1),pp.25
著者・共著者	Suzuki Yoko, Taniguchi Kohei, Hatono Minami, Kajiwara Yukiko, Abe Yuko, Kawada Kengo, Tsukioki Takahiro, Kochi Mariko, Nishiyama Keiko, Iwamoto Takayuki, Ikeda Hirokuni, Shien Tadahiko, Taira Naruto, Tabata Masahiro, Yanai Hiroyuki, Doihara Hiroyoshi
発行年月	2020/01
概要	BACKGROUND:Angiosarcoma of the breast is very rare and can be divided into primary and secondary angiosarcoma. Radiation-induced angiosarcoma (RIAS) is classified as secondary angiosarcoma. Diagnosis of RIAS is difficult due to its rarity, and the interpretation of pathological imaging is complicated. In the National Comprehensive Care Network (NCCN) guidelines, the first choice of treatment is surgery with negative margins. Adjuvant radiotherapy (RT) for close soft tissue margins should be considered. Preoperative or adjuvant chemotherapy of nonmetastatic disease is not recommended for angiosarcoma. We report a case of RIAS, which was impossible to diagnose with core needle biopsy (CNB) but was diagnosed by excisional biopsy. The patient was then administered adjuvant chemotherapy using conjugated paclitaxel (PTX).CASE PRESENTATION:A 62-year-old woman noticed a tumor in her right breast. She had a history of right breast cancer and had undergone breast-conserving surgery, RT, and tamoxifen therapy 8 years previously. CNB, which was performed twice, was inconclusive. The tumor was surgically excised and pathological analysis yielded a diagnosis of angiosarcoma. She then underwent a right mastectomy. One month after she underwent right mastectomy, a nodule reappeared on the skin of her right breast, and excisional biopsy revealed recurrence of angiosarcoma. A few weeks later another nodule reappeared near the post-operative scar and excisional biopsy revealed recurrence of angiosarcoma. We assumed that surgical therapy was insufficient because the patient experienced relapse of angiosarcoma after complete mastectomy. After the second recurrence, we treated her with systemic chemotherapy using PTX. There was no evidence of recurrence 8 months after chemotherapy
DOI	10.1186/s40792-020-0790-7
PMID	31950295