ドイハラ　ヒロヨシ   Hiroyoshi Doihara   土井原　博義    所属   川崎医科大学  医学部 臨床医学　総合外科学    職種   特任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Influences of preoperative metformin on immunological factors in early breast cancer.
掲載誌名	正式名：Cancer chemotherapy and pharmacology 略　 称：Cancer Chemother Pharmacol ISSNコード：14320843/03445704
掲載区分	国外
巻・号・頁	86(1),pp.55-63
著者・共著者	Tsukioki Takahiro, Shien Tadahiko, Tanaka Takehiro, Suzuki Yoko, Kajihara Yukiko, Hatono Minami, Kawada Kengo, Kochi Mariko, Iwamoto Takayuki, Ikeda Hirokuni, Taira Naruto, Doihara Hiroyoshi, Toyooka Shinichi
発行年月	2020/07
概要	PURPOSE:Metformin has been suggested to possibly reduce cancer risk. However, the mechanism underlying the positive effects of metformin on cancer treatment remains unclear. We conducted a prospective study to evaluate the effects of preoperative metformin in patients with early breast cancer.METHOD:We evaluated the effects on immunological factors (TILs, CD4 + , CD8 + , PD-L1, IFNγ and IL-2) by comparing core needle biopsies (CNB) obtained before metformin treatment with surgical specimens. Seventeen patients were enrolled in this prospective study from January to December 2016. We also analyzed 59 patients undergoing surgery during the same period to reveal the correlation of immune factors between CNB and surgical specimen.RESULT:There was a moderate correlation between CNB and surgical specimens on TILs and CD8 + lymphocyte. (TILs Rs = 0.63, CD4 + Rs = 0.224, CD8 + Rs = 0.42) In the metformin group, TILs increases were confirmed in five (29%) patients, while a decrease was confirmed in two (12%). The expressions of CD4 + and CD8 + by TILs were increased in 41% and 18% of surgical specimens, respectively. However, TILs number (p = 0.0554), CD4+ (p = 0.0613) and CD8 + (p = 0.0646) expressions did not significantly increased. Furthermore, IFNγ expression appeared to be increased in response to metformin (p = 0.08).CONCLUSION:Preoperative metformin tends to increase TILs, as well as the numbers of CD4 and CD8 positive lymphocytes, and IFNγ levels. Metformin might improve immune function and have a possibility of chemo-sensitivity and thereby increase the effectiveness of immunotherapy, based on the results of this preliminary study.
DOI	10.1007/s00280-020-04092-2
PMID	32533334