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ドイハラ ヒロヨシ
Hiroyoshi Doihara
土井原 博義 所属 川崎医科大学 医学部 臨床医学 総合外科学 職種 特任教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Radiofrequency Ablation of Breast Cancer: A Retrospective Study. |
| 掲載誌名 | 正式名：Clinical breast cancer 略 称：Clin Breast Cancer ISSNコード：19380666/15268209 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 18(4),pp.e495-e500 |
| 著者・共著者 | Ito Toshikazu, Oura Shoji, Nagamine Shinji, Takahashi Masato, Yamamoto Naohito, Yamamichi Noboru, Earashi Mitsuharu, Doihara Hiroyoshi, Imoto Shigeru, Mitsuyama Shoshu, Akazawa Kohei |
| 発行年月 | 2018/08 |
| 概要 | PURPOSE:To validate the safety and efficacy of percutaneous radiofrequency ablation (RFA) of breast carcinomas.METHODS:This retrospective study was conducted by the Breast Cancer Society for Minimally Invasive Therapy following approval from institutional review boards, and with the written informed consent of patients. A total of 386 patients with breast cancer treated with RFA at 10 institutions between July 2003 and June 2009 were identified and included in the analysis. Patients underwent a standard RFA procedure with ultrasound guidance and were followed up every 6 to 12 months. In this study, feasibility of RFA procedure and related safety and ipsilateral breast tumor recurrence (IBTR) were examined. Fisher exact or χ2 test evaluated associations between clinicopathological factors and IBTR, and local recurrence-free survival was estimated using the Kaplan-Meier method.RESULTS:RFA-related adverse events included local pain in 9 patients, skin burns in 15, and nipple retraction in 7. Patients were followed for a median of 50 months. IBTR was more frequently observed in patients with initial tumor sizes > 2 cm (3 of 30, 10%) than in those with initial tumors ≤ 2 cm (8 of 355, 2.3%; P = .015). IBTR-free rates 5 years after RFA were 97%, 94%, and 87% in patients with initial tumor sizes ≤ 1.0 cm, 1.1 to 2.0 cm, and > 2.0 cm, respectively.CONCLUSIONS:RFA in breast cancer is a safe and promising minimally invasive treatment for tumors ≤ 2 cm in diameter. Further studies are needed to optimize the technique and evaluate its future role as local therapy. |
| DOI | 10.1016/j.clbc.2017.09.007 |
| PMID | 29079443 |