トノムラ　ソウタツ   Sotatsu Tonomura   外村　宗達    所属   川崎医科大学  医学部 基礎医学　解剖学    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Electrophysiological properties of maxillary trigeminal Abeta-afferent neurons of rats
掲載誌名	正式名：Molecular pain 略　 称：Mol Pain ISSNコード：17448069
掲載区分	国外
巻・号・頁	17,pp.17448069211021271
著者・共著者	Okutsu, Y. Yamada, A. Tonomura, S. Vaden, R. J. Gu, J. G.
発行年月	2021
概要	Abeta-afferents in maxillary or V2 trigeminal ganglion (TG) neurons are somatosensory neurons that may be involved in both non-nociceptive and nociceptive functions in orofacial regions. However, electrophysiological properties of these V2 trigeminal Abeta-afferent neurons have not been well characterized so far. Here, we used rat ex vivo trigeminal nerve preparations and applied patch-clamp recordings to large-sized V2 TG neurons to characterize their electrophysiological properties. All the cells recorded had afferent conduction velocities in the range of Abeta-afferent conduction speeds. However, these V2 trigeminal Abeta-afferent neurons displayed different action potential (AP) properties. APs showed fast kinetics in some cells but slow kinetics with shoulders in repolarization phases in other cells. Based on the derivatives of voltages in AP repolarization with time (dV/dt), we classified V2 trigeminal Abeta-afferent neurons into four types: type I, type II, type IIIa and type IIIb. Type I V2 trigeminal Abeta-afferent neurons had the largest dV/dt of repolarization, the fastest AP conduction velocities, the shortest AP and afterhyperpolarization (AHP) durations, and the highest AP success rates. In contrast, type IIIb V2 trigeminal Abeta-afferent neurons had the smallest dV/dt of AP repolarization, the slowest AP conduction velocities, the longest AP and AHP durations, and the lowest AP success rates. The type IIIb cells also had significantly lower voltage-activated K(+) currents. For type II and type IIIa V2 trigeminal Abeta-afferent neurons, AP parameters were in the range between those of type I and type IIIb V2 trigeminal Abeta-afferent neurons. Our electrophysiological classification of V2 trigeminal Abeta-afferent neurons may be useful in future to study their non-nociceptive and nociceptive functions in orofacial regions.
DOI	10.1177/17448069211021271
文献番号	34056968