トノムラ　ソウタツ   Sotatsu Tonomura   外村　宗達    所属   川崎医科大学  医学部 基礎医学　解剖学    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier for Rapid Action Potential Conduction on Mammalian Myelinated Afferent Nerves.
掲載誌名	正式名：Neuron 略　 称：Neuron ISSNコード：10974199/08966273
掲載区分	国外
巻・号・頁	104(5),pp.960-971.e7
著者・共著者	Kanda Hirosato, Ling Jennifer, Tonomura Sotatsu, Noguchi Koichi, Matalon Sadis, Gu Jianguo G
発行年月	2019/12
概要	Rapid conduction of nerve impulses is critical in life and relies on action potential (AP) leaps through the nodes of Ranvier (NRs) along myelinated nerves. While NRs are the only sites where APs can be regenerated during nerve conduction on myelinated nerves, ion channel mechanisms underlying the regeneration and conduction of APs at mammalian NRs remain incompletely understood. Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Aβ-afferent nerves with a density over 3,000-fold higher than that on their somas. These K2P channels, but not voltage-gated K+ channels as in other parts of nerves, are required for rapid AP repolarization at the NRs. Furthermore, these channels permit high-speed and high-frequency AP conduction along the myelinated afferent nerves, and loss of function of these channels at NRs retards nerve conduction and impairs sensory behavioral responses in animals.
DOI	10.1016/j.neuron.2019.08.042
PMID	31630908