ミウラ　ミチ   Michi Miura   三浦　未知    所属   川崎医科大学  医学部 基礎医学　微生物学    職種   助教
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Regulation of Latency in the Human T Cell Leukemia Virus, HTLV-1.
掲載誌名	正式名：Annual review of virology 略　 称：Annu Rev Virol ISSNコード：23270578/2327056X
掲載区分	国外
巻・号・頁	6(1),pp.365-385
著者・共著者	Bangham Charles R M, Miura Michi, Kulkarni Anurag, Matsuoka Masao
担当区分	2nd著者
発行年月	2019/09
概要	The human T cell leukemia virus persists in vivo in 103 to 106 clones of T lymphocytes that appear to survive for the lifetime of the host. The plus strand of the provirus is typically transcriptionally silent in freshly isolated lymphocytes, but the strong, persistently activated cytotoxic T lymphocyte (CTL) response to the viral antigens indicates that the virus is not constantly latent in vivo. There is now evidence that the plus strand is transcribed in intense intermittent bursts that are triggered by cellular stress, modulated by hypoxia and glycolysis, and inhibited by polycomb repressive complex 1 (PRC1). The minus-strand gene hbz is transcribed at a lower, more constant level but is silent in a proportion of infected cells at a given time. Viral genes in the sense and antisense strands of the provirus play different respective roles in latency and de novo infection: Expression of the plus-strand gene tax is essential for de novo infection, whereas hbz appears to facilitate survival of the infected T cell clone in vivo.
DOI	10.1146/annurev-virology-092818-015501
PMID	31283437