モリヤ　タクヤ   Takuya Moriya   森谷　卓也    所属   川崎医科大学  医学部 臨床医学　病理学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A Triple-negative Matrix-producing Breast Carcinoma Patient-derived Orthotopic Xenograft (PDOX) Mouse Model Is Sensitive to Bevacizumab and Vinorelbine, Regressed by Eribulin and Resistant to Olaparib.
掲載誌名	正式名：Anticancer research 略　 称：Anticancer Res ISSNコード：17917530/02507005
掲載区分	国外
巻・号・頁	40(5),pp.2509-2514
著者・共著者	Yamamoto Jun, Murata Takuya, Tashiro Yoshihiko, Higuchi Takashi, Sugisawa Norihiko, Nishino Hiroto, Inubushi Sachiko, Sun Y U, Lim Hyein, Miyake Kentaro, Hongo Atsushi, Nomura Tsunehisa, Saitoh Wataru, Moriya Takuya, Tanino Hirokazu, Hozumi Chihiro, Bouvet Michael, Singh Shree Ram, Endo Itaru, Hoffman Robert M
発行年月	2020/05
概要	BACKGROUND/AIM:Matrix-producing breast carcinoma (MPBC) is a rare and usually aggressive triple-negative breast cancer (TNBC). In this study, we determined drug sensitivity for a triple-negative MPBC, without BRCA mutations, in a patient-derived orthotopic xenograft (PDOX) model.MATERIALS AND METHODS:The MPBC PDOX model was established in the left 2nd mammary gland of nude mouse by implantation of the patient tumor using surgical orthotopic implantation (SOI). We randomized MPBC PDOX mice into 5 groups (n=5 mice/per treatment group) when the tumor volume reached 80 mm3: G1, control-no treatment; G2, bevacizumab [intra-peritoneal (i.p.), weekly, for 2 weeks]; G3, vinorelbine (i.p., weekly, for 2 weeks); G4, olaparib (oral., daily, for 2 weeks); G5, eribulin [intravenous (i.v.), weekly, for 2 weeks]. The mice in each treatment group were sacrificed on day 15. Tumor volume and body weight were measured once/week.RESULTS:The MPBC PDOX model was resistant to olaparib (p=0.22). The MPBC PDOX model treated with bevacizumab and vinorelbine showed significantly suppressed tumor growth compared to the untreated group (p=0.005 and 0.002, respectively). However, only eribulin regressed the tumor (p=0.0001). Eribulin was more effective than olaparib (p=0.0001), bevacizumab (p=0.0025) and vinorelbine (p=0.0061).CONCLUSION:Eribulin has clinical potential as treatment for triple-negative MPBC patients that are resistant to a PARP inhibitor such as olaparib.
DOI	10.21873/anticanres.14221
PMID	32366395