スギモト ケン
Ken Sugimoto
杉本 研 所属 川崎医科大学 医学部 臨床医学 総合老年医学 職種 教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | A klotho gene single nucleotide polymorphism is associated with the onset of stroke and plasma klotho concentration. |
掲載誌名 | 正式名:Aging 略 称:Aging (Albany NY) ISSNコード:19454589/19454589 |
掲載区分 | 国外 |
巻・号・頁 | 11(1),pp.104-114 |
著者・共著者 | Yokoyama Serina, Oguro Ryosuke, Yamamoto Koichi, Akasaka Hiroshi, Ito Norihisa, Kawai Tatsuo, Kusunoki Hiroshi, Takeya Yasushi, Takeya-Onishi Miyuki, Yamamoto-Hanasaki Hiroko, Sugimoto Ken, Ikebe Kazunori, Gondo Yasuyuki, Ohishi Mitsuru, Kamide Kei, Rakugi Hiromi |
発行年月 | 2018/12 |
概要 | Klotho protects against development of multiple age-related disorders, including cardiovascular diseases. We assessed whether a human klotho single nucleotide polymorphism (SNP) rs650439 is associated with the onset of stroke in hypertensive patients and plasma klotho concentration in the general population. Five hundred and twenty-three patients with hypertension were analyzed for both the presence of rs650439 and onset of stroke. We found that hypertensive patients with the TT genotype of rs650439 (n=52) had a higher incidence of stroke than those with AT (n=257) and AA (n=214) genotypes. Multivariate analysis indicated that the TT genotype was the only risk factor associated with increased incidence of stroke. Plasma klotho concentrations were measured in a general population (age=70±1 years) to assess the association between rs650439 and plasma klotho concentration. A significant trend was observed in the elderly population where plasma klotho concentration decreased as the T alleles in rs650439 increased. Subjects with a TT genotype had lower plasma klotho concentrations than those with AT+AA genotypes. In conclusion, TT genotype of klotho SNP (rs650439) is correlated with an increased incidence of stroke in hypertensive patients, and the mechanism underlying this correlation might involve the effect of rs650439 T allele on plasma klotho concentrations. |
DOI | 10.18632/aging.101728 |
PMID | 30595559 |