サトウ　ケイタ   Keita Sato   佐藤　慧太    所属   川崎医科大学  医学部 基礎医学　解剖学    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Variations in GABA immunoreactivity among granule cells of the mouse olfactory bulb, as revealed by high-voltage electron microscopy.
掲載誌名	正式名：Neuroscience letters 略　 称：Neurosci Lett ISSNコード：18727972/03043940
掲載区分	国外
巻・号・頁	738,pp.135386
著者・共著者	Satoh Keita, Kiyokage Emi, Ichikawa Satoshi, Toida Kazunori
担当区分	筆頭著者
発行年月	2020/09
概要	Odor information is processed in the olfactory bulb (OB), which is organized into olfactory inputs, interneurons, projection neurons, and centrifugal inputs, and these various structures regulate olfactory information processing. Similar to other brain regions, the OB structures include many types of interneurons, including γ-aminobutyric acid (GABA)ergic interneurons. Many interneurons are granule cells that are found in the granule cell layer (GCL), which is a deep layer of the OB. Interestingly, these interneurons exhibit variations in GABA immunoreactivity, and previous studies have observed differing intensities among morphologically and chemically similar neuronal populations. However, the numbers and distribution patterns of cells that show variations in GABA immunoreactivity are unknown. Therefore, we observed and quantitatively analyzed this diversity in the GCL of the mouse OB using immunogold, high-voltage electron microscopy, combined with light microscopy. Consequently, our results clearly show variations in the GABA immunoreactivity among GCL interneurons, which suggested heterogeneity in the amount of GABA present in each interneuron and reflected the possibility that different amounts of neuroactive substances may be associated with different functions for the various GABAergic interneuron groups. Variations in GABA immunoreactivity could be a novel criterion for classifying interneuron subpopulations.
DOI	10.1016/j.neulet.2020.135386
PMID	32947006