ヒガシダ　マサハル   Masaharu Higashida   東田　正陽    所属   川崎医科大学  医学部 臨床医学　消化器外科学    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Is it Necessary to Confirm Negative Margins in Gastrectomy for Peritoneal Lavage Cytology-positive Gastric Cancer?
掲載誌名	正式名：Anticancer research 略　 称：Anticancer Res ISSNコード：17917530/02507005
掲載区分	国外
巻・号・頁	40(10),pp.5807-5813
著者・共著者	Shunji Endo, Yoshinori Fujiwara, Tomoki Yamatsuji, Kazuhiro Nishikawa, Kazumasa Fujitani, Masakazu Ikenaga, Junji Kawada, Yuko Okamoto, Hisako Kubota, Masaharu Higashida, Tomio Ueno
発行年月	2020/10
概要	BACKGROUND/AIM:The survival benefit of negative resection margins in patients who undergo gastrectomy with positive peritoneal lavage cytology (CY1) is unknown.PATIENTS AND METHODS:We reviewed the medical records of 128 patients with CY1 but no other distant metastases who had undergone R1 gastrectomy, 21 of whom had positive margins. We compared overall survival (OS) according to margin status.RESULTS:The positive-margin group had poorer performance status scores (p=0.02), higher number of patients had undergone limited lymphadenectomy (p=0.01), had type 4 tumors (p=0.01), and undifferentiated type (p=0.02). Median OS was 19.0 and 16.9 months in the groups with negative and positive margins, respectively (HR=1.26, 95%CI=0.75-2.12, p=0.39). An inverse probability of treatment weighted analysis showed an OS of 13.1 and 11.9 months for the groups with negative and positive margins, respectively (HR=0.83, 95%CI=0.43-1.63, p=0.59).CONCLUSION:The prognoses of patients with CY1 and negative or positive margins may be equivalent.
DOI	10.21873/anticanres.14598
PMID	32988909