キムラ　シュウヘイ   木村　修平    所属   川崎医科大学  医学部 臨床医学　眼科学１    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Retinal sensitivity after displacement of submacular hemorrhage due to polypoidal choroidal vasculopathy: effectiveness and safety of subretinal tissue plasminogen activator.
掲載誌名	正式名：Japanese journal of ophthalmology 略　 称：Jpn J Ophthalmol ISSNコード：16132246/00215155
掲載区分	国外
巻・号・頁	61(6),pp.472-478
著者・共著者	Kimura Shuhei, Morizane Yuki, Matoba Ryo, Hosokawa Mio, Shiode Yusuke, Hirano Masayuki, Doi Shinichiro, Toshima Shinji, Takahashi Kosuke, Hosogi Mika, Fujiwara Atsushi, Shiraga Fumio
担当区分	筆頭著者
発行年月	2017/11
概要	PURPOSE:To investigate the effectiveness of displacement of submacular hemorrhage (SMH) caused by polypoidal choroidal vasculopathy (PCV) by assessing retinal sensitivity using microperimetry.METHODS:We retrospectively reviewed the medical records of 11 consecutive PCV patients with SMH. All patients underwent vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-air exchange, followed by antivascular endothelial growth factor therapy using a pro re nata regimen. The retinal sensitivity was measured by use of microperimetry before and after surgery.RESULTS:The mean (SD) age of the patients was 74.1 ± 9.4 years. The mean SMH diameter was 6.8 ± 5.2 disc diameters. The best-corrected visual acuity (BCVA), mean retinal sensitivity, and mean number of measure points with a sensitivity ≥10 dB before the surgery were 0.94 ± 0.49, 4.2 ± 4.5 dB, and 15.6 ± 15.1 points, respectively. These had significantly improved 6 months after surgery (0.39 ± 0.37, 15.6 ± 7.3 dB, and 50.9 ± 22.2 points, respectively; P < 0.05 for all outcome measures). The mean number of measure points with an absolute scotoma before surgery had decreased significantly 6 months after surgery (from 40.5 ± 15.0 to 9.4 ± 16.0 points; P < 0.001).CONCLUSIONS:Displacement of SMH effectively improves retinal sensitivity as well as BCVA.
DOI	10.1007/s10384-017-0530-0
PMID	28836011