フジワラ　アツシ   Atsushi Fujiwara   藤原　篤之    所属   川崎医療福祉大学  リハビリテーション学部 視能療法学科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Six-month results of intravitreal aflibercept injections for patients with polypoidal choroidal vasculopathy.
掲載誌名	正式名：The British journal of ophthalmology 略　 称：Br J Ophthalmol ISSNコード：14682079/00071161
掲載区分	国外
巻・号・頁	99(8),pp.1087-1091
著者・共著者	Hosokawa Mio, Shiraga Fumio, Yamashita Ayana, Shiragami Chieko, Ono Aoi, Shirakata Yukari, Kimura Shuhei, Shiode Yusuke, Kawata Tetsuhiro, Hosogi Mika, Fujiwara Atsushi, Morizane Yuki
発行年月	2015/08
概要	BACKGROUND:This study aims to evaluate the therapeutic effect of intravitreal aflibercept injection for polypoidal choroidal vasculopathy (PCV).METHODS:Eighteen eyes of 17 consecutive patients with PCV received three consecutive monthly intravitreal injections of aflibercept and one additional injection 2 months later (four injections totally). All patients underwent eye examinations, which included best-corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, and optical coherence tomography. The primary endpoint of the study was the regression of polypoidal lesions. The secondary endpoints were BCVA, central retinal thickness (CRT) and changes in retinal exudation.RESULTS:Six months after the first aflibercept injection, the polypoidal lesions were completely resolved in 14 eyes (77.7%) and partially resolved in 4 eyes (22.2%). Although branching choroidal vascular networks were still present in all eyes, retinal exudative changes had completely resolved in 17 eyes (94.4%), and the mean CRT decreased significantly from 407.2±100.1 µm to 229.1±57.2 µm (p<0.0001). BCVA (logarithm of the minimal angle of resolution, logMAR) improved significantly from 0.414±0.384 at baseline to 0.297±0.334 after 6 months (p=0.016).CONCLUSIONS:At 6 months, aflibercept monotherapy effectively reduced polyps, retinal exudation and CRT in patients with PCV.
DOI	10.1136/bjophthalmol-2014-305275
PMID	25712826