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ミハラ マサヒト
Masahito Mihara
三原 雅史 所属 川崎医科大学 医学部 臨床医学 神経内科学 職種 教授 |
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| 論文種別 | 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Quantifying changes in nigrosomes using quantitative susceptibility mapping and neuromelanin imaging for the diagnosis of early-stage Parkinson's disease. |
| 掲載誌名 | 正式名：The British journal of radiology 略 称：Br J Radiol ISSNコード：1748880X/00071285 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 91(1086),pp.20180037 |
| 著者・共著者 | Takahashi Hiroto, Watanabe Yoshiyuki, Tanaka Hisashi, Mihara Masahito, Mochizuki Hideki, Liu Tian, Wang Yi, Tomiyama Noriyuki |
| 発行年月 | 2018/06 |
| 概要 | OBJECTIVE:To quantify nigral changes with a focus on their spatial variation within the substantia nigra pars compacta (SNpc) for diagnosing early-stage Parkinson's disease (PD).METHODS:The study participants were 18 patients with early-stage PD (PD group) and 18 healthy controls (HC group) who underwent quantitative susceptibility mapping (QSM) and neuromelanin imaging. The QSM and neuromelanin values in each whole SNpc containing the entire nigrosome and dorsolateral SNpc containing nigrosome 1 were calculated. The neuromelanin area was defined as the volume with a signal-to-noise ratio higher than that of the background region. The significance of intergroup differences in the QSM value and neuromelanin area in each SNpc region was tested. Logit (p) was used to estimate the probability of PD in relation to the QSM value and the neuromelanin area, and receiver operating characteristic analyses were performed for each value.RESULTS:In both SNpc, QSM values were significantly higher and neuromelanin areas were significantly lower in the PD group compared with the HC group (p < 0.05). The respective areas under the receiver operating characteristic curve for the two groups were 0.70/0.73 for the QSM value, 0.81/0.78 for the neuromelanin area in the whole/dorsolateral SNpc, and 0.86 for logit (p) in relation to the QSM value of the dorsolateral SNpc and the neuromelanin area of the whole SNpc.CONCLUSION:Comprehensive MRI assessment of the abnormality involving the nigrosomes can yield a high diagnostic performance for early-stage PD. Advances in knowledge: Focusing on spatial differences in nigral changes within the SNpc can increase the sensitivity of the detection of PD-related neurodegenerative changes. |
| DOI | 10.1259/bjr.20180037 |
| PMID | 29498540 |