ヤノ ヒロミ
Yano Hiromi
矢野 博己 所属 川崎医療福祉大学 医療技術学部 健康体育学科 職種 教授 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells |
掲載誌名 | 正式名:Journal of Immunological Methods 略 称:J Immunol Methods |
巻・号・頁 | 393(1-2),pp.61-69 |
著者・共著者 | Masataka Uchida, Eri Oyanagi, Motohiko Miyachi, Akira Yamauchi, Hiromi Yano |
担当区分 | 最終著者,責任著者 |
発行年月 | 2013/07 |
概要 | We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin. |
DOI | 10.1016/j.jim.2013.04.007 |