ヤノ　ヒロミ   Yano Hiromi   矢野　博己    所属   川崎医療福祉大学  医療技術学部 健康体育学科    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Exercise training attenuates hepatic inflammation, fibrosis and macrophage infiltration during diet induced-obesity in mice.
掲載誌名	正式名：Brain, Behavior, and Immunity 略　 称：Brain Behav Immun ISSNコード：08891591/10902139
巻・号・頁	26(6),pp.931-941
著者・共著者	Noriaki Kawanishi, Hiromi Yano, Tsubasa Mizokami, Masaki Takahashi, Eri Oyanagi, Katsuhiko Suzuki
担当区分	2nd著者
発行年月	2012/08
概要	Nonalcoholic steatohepatitis, which is considered the hepatic event in metabolic syndrome, was recently associated with the innate immune system. Although regular exercise reduces hepatic injurymarkers like serum alanine aminotransferase (ALT) levels, the mechanisms regulating the effects of exercise on steatohepatitis are unclear. This study aimed to clarify whether exercise training suppresses hepatic injury, inflammation, and fibrosis by suppressing macrophage infiltration. Male C57BL/6J (4-week old) mice were randomly divided into four groups: normal diet (ND) control (n = 7), ND exercise (n = 5), high-fat diet and high-fructose water (HFF) control (n = 11), and HFF exercise (n = 11) groups. Mice were fed the ND or HFF from 4 to 20 weeks of age. The exercise groups were trained on a motorized treadmill for 60 min/day, five times/week. The nonalcoholic fatty liver disease (NAFLD) activity score and plasma ALT activity, indicators of liver injury, were increased in HFF control mice but were attenuated in HFF exercise mice. Hepatic inflammation, indicated by hepatic tumor necrosis factor (TNF)-a levels and hepatic resident macrophage infiltration, was significantly lower in HFF exercise mice than in HFF control mice. Hepatic fibrosis markers (histological hepatic fibrosis detected by Sirius red and a-smooth muscle actin staining and tissue inhibitor of matrix metalloproteinase-1 mRNA) were attenuated in HFF exercise mice compared with HFF control mice. These results suggest that exercise training reduces hepatic inflammation, injury, and fibrosis by suppressing macrophage infiltration.