ウシロガワ　ヒロシ   Hiroshi Ushirogawa   後川　潤    所属   川崎医科大学  医学部 基礎医学　微生物学    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin.
掲載誌名	正式名：Virology Journal 略　 称：Virol J
巻・号・頁	8,pp.50 (1-8)
著者・共著者	Tokunaga Hirotoshi, Ushirogawa Hiroshi, Ohuchi Masanobu
担当区分	2nd著者
発行年月	2011/02
概要	Background Mannose-binding lectin (MBL) is an important component of innate immunity because it promotes bacterial clearance and neutralization of human influenza A viruses. Since a majority of humans have no neutralizing antibody against the pandemic (H1N1) 2009 influenza (pandemic 2009) virus, innate immunity may be crucial and MBL susceptibility may therefore influence viral pathogenesis. Results We examined MBL susceptibility of influenza A viruses and observed that the pandemic 2009 virus was resistant to MBL, whereas all seasonal influenza A viruses tested were susceptible. The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus. This indicates that MBL protects mice against infection with the seasonal virus but not against that with the pandemic 2009 virus. Conclusion These results indicate that the pandemic 2009 virus is not susceptible to MBL, an important component of innate immunity.
DOI	10.1186/1743-422X-8-50
文献番号	PMID: 21294904