クロカワ　カツミ   Katsumi Kurokawa   黒川　勝己    所属   川崎医科大学  医学部 臨床医学　総合内科学１    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Muscular fatigue and decremental response to repetitive nerve stimulation in X-linked spinobulbar muscular atrophy
掲載誌名	正式名：European journal of neurology : the official journal of the European Federation of Neurological Societies 略　 称：Eur J Neurol ISSNコード：13515101/14681331
巻・号・頁	16,pp.76-80
著者・共著者	Inoue Ken, Hemmi Shoji, Miyashita Masahiro, Kutoku Yumiko, Murakami Tatsufumi, Kurokawa Katsumi, Sunada Yoshihide
発行年月	2009
概要	Background and Purpose: We report decremental responses to repetitive nerve stimulation (RNS) in 11 patients diagnosed with X-linked spinobulbar muscular atrophy (X-SBMA). Methods: The compound muscle action potential (CMAP) of the right abductor digiti minimi (ADM) and trapezius (TZ) in response to a 3-Hz stimulation of the ulnar nerve at the wrist and accessory nerve at the neck were recorded by surface electrodes. Results: A decremental response to RNS was observed in 90.9 % of the TZ muscle and 27.2 % in ADM muscle of patients with X-SBMA. Conclusion: These electrophysiological features of X-SBMA are considered to be usuful for diagnosis of X-SBMA. Furthermore, the waning phenomena that mostly appeared in the TZ muscle and increment of CMAP in RNS after the exercise also suggest a unique menifestation in X-SBMA.