オオシロ　ヨシユキ   Yoshiyuki Oshiro   大城　義之    所属   川崎医科大学  医学部 臨床医学　総合内科学３    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Expression of the fibroblast growth factor receptor 1-4 genes in glomeruli in anti-Thy1.1 mesangial proliferative glomerulonephritis.
掲載誌名	正式名：Virchows Archiv : an international journal of pathology 略　 称：Virchows Arch ISSNコード：09456317
掲載区分	国外
巻・号・頁	435(5),pp.501-508
著者・共著者	Jyo-Oshiro Y, Sasaki T, Kawakami Y, Nohno T, Itoh N, Osawa G, Kashihara N.
担当区分	筆頭著者,責任著者
発行年月	1999/11
概要	Basic fibroblast growth factor (FGF2) is generally known to induce proliferation of cultured mesangial cells and is expressed in proliferative mesangial cells in anti-Thy1.1 mesangial proliferative glomerulonephritis (anti-Thy1.1 GN). The distribution of the FGF receptor (FGFR) has not been studied in anti-Thy1.1 GN, so we used in situ hybridization to determine whether cells expressing FGFR1-4 mRNAs could be detected. In normal rats, all glomeruli were negative for FGFR1-4 mRNA, but those of the mesangial proliferative phase expressed FGFR1-4 mRNA in proliferative mesangial cells. Proliferation of mesangial cells has not been observed in normal rats injected with FGF2 but it has been noted in anti-Thy1.1 rats injected with FGF2. These data and our results demonstrate that mesangial cells produce and release FGF2 after injury and that during the proliferative phase these cells upregulate FGFR in vivo. This study is the first to demonstrate expression of FGFR1-4, mRNAs in pathological glomeruli of anti-Thy1.1 GN. The FGF2 and FGFR1-4 genes were expressed in the proliferative mesangial cells. Upregulation of FGFR is necessary for mesangial proliferation by FGF2.
DOI	10.1007/s004280050434
文献番号	10592054