Faculty Information - Yuta Ishizuka

■ Present specialized field

Neuroscience-general, Pathological biochemistry, Cell biology (Key Word：Synaptic plasticity, Neurodegenerative disorder, Metabolic disorder, Lysosomal storage disease, Glycosphingolipid, saposin)

■ BooK

1.	2017/02/09		Drebrin in Alzheimer’s Disease, Drebrin
2.	2012/01		AUTONOMIC DRUGS「Katzung & Trevor’s Pharmacology Examination & Board Review 9th edition」

■ Journal

1.	2024/09	A nanobody-based proximity ligation assay detects constitutive and stimulus-regulated native Arc/Arg3.1 oligomers in hippocampal neuronal dendrites
2.	2023/06/20	Genetic ablation of Saposin-D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination
3.	2023/05	Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo
4.	2022/12	The Urinary Bladder is Rich in Glycosphingolipids Composed of Phytoceramides
5.	2022/03	Development and validation of Arc nanobodies: new tools for probing Arc dynamics and function.
6.	2021/02	Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines.
7.	2020/08	Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis.
8.	2020/03	A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons.
9.	2017/06	The role of drebrin in neurons.
10.	2016/06	Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice.
11.	2016/04	X Irradiation Induces Acute Cognitive Decline via Transient Synaptic Dysfunction.
12.	2015/10	Allopregnanolone increases mature excitatory synapses along dendrites via protein kinase A signaling.
13.	2015/08	Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons.
14.	2014/10	Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers.
15.	2014/01	Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines.
16.	2013/10	AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons.
17.	2011/07	Qualitative and quantitative re-evaluation of epidermal growth factor-ErbB1 action on developing midbrain dopaminergic neurons in vivo and in vitro: target-derived neurotrophic signaling (Part 1).
18.	2010/12	The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats.
19.	2009/09	Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons.
20.	2008/07	Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporter.
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■ Presentation

1.	2023/10/06	Selective Degeneration of Retinal Photoreceptor Cell in Prosaposin Transgenic Mice （Speech，General）
2.	2023/07/06	Degeneration of Retinal Photoreceptor Cell in Prosaposin Transgenic Mice （Poster notice，General）
3.	2022/11/24	Establishment of cryopreserved neuronal cell bank -Analysis of Saposin D mutant neuron- （Poster notice，General）
4.	2022/07	Development and validation of Arc nanobodies: new tools for probing　Arc dynamics and function （Poster notice，General）
5.	2020/07	A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons （Poster notice，General）
6.	2019/07	Study of the interaction between Arc and drebrin in synaptic plasticity （Poster notice，General）
7.	2017/06	Amyloid beta oligomers induce drebrin disappearance from dendritic spines via histone deacetylase activity （Poster notice，General）
8.	2016/09	Study of the interaction between Arc and drebrin in synaptic plasticity （Poster notice，General）
9.	2015/09	Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers （Speech，Panelist at Symposium/Workshop (Appointed)）
10.	2015/08	Histone deacetylase mediates drebrin loss from dendritic spines induced by amyloid beta oligomers （Poster notice，General）
11.	2015/02	Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid b-derived diffusible ligands （Poster notice，General）
12.	2014/09	Amyloid beta oligomers induce drebrin exodus from dendritic spines via histone deacetylase （Poster notice，General）
13.	2014/09	Amyloid beta oligomers induce drebrin exodus from dendritic spines via histone deacetylase （Poster notice，General）
14.	2014/07	Histone deacetylase is involved in the decrease of drebrin cluster density induced by amyloid beta oligomers （Poster notice，General）
15.	2014/03	Synapse vulnerability induced Amyloid β-derived diffusible ligands is blocked by the inhibitor of histone deacetylase （Poster notice，General）
16.	2013/08	Histone deacetylase (HDAC) inhibitor attenuates amyloid beta-induced synaptic dysfunction （Poster notice，General）
17.	2013/07	Histone deacetylase (HDAC) inhibitor attenuates amyloid beta-induced synaptic dysfunction （Poster notice，General）
18.	2013/03	Histone deacetylase (HDAC) inhibitor attenuates amyloid beta-induced synaptic dysfunction （Poster notice，General）
19.	2012/09	AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling and protein synthesis in neurons （Speech，Panelist at Symposium/Workshop (Appointed)）
20.	2011/08	AMPK regulates BDNF-induced activation of mTOR signaling and enhancement of translation in cortical neurons （Poster notice，General）
21.	2010/07	AMPK regulates BDNF-induced activation of mTOR signaling and enhancement of translation in cortical neurons （Poster notice，General）
22.	2009/12	5’-AMP-activated protein kinase (AMPK) suppresses protein synthesis in neurons through down-regulated mammalian target of rapamycin (mTOR) signaling （Poster notice，General）
23.	2008/12	Leucine induces phosphorylation and activation of p70S6K in cortical neurons via system L amino acid transporter （Poster notice，General）
24.	2007/12	Roles of 5’-AMP-activated protein kinase (AMPK) on the regulation of mTOR signaling in neurons （Poster notice，General）
25.	2006/08	Roles of glucose on the AMPK phosphorylation and translation in neurons （Speech，General）
26.	2005/08	Leucine enhances p70S6Kinase signaling in cortical neurons （Poster notice，General）
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■ Belonging society

1.		The Japan Neuroscience Society
2.		the Japanese Society for Inherited Matabolic Diseases
3.		The Japanese Society for Neurochemistry

■ Winning science prize

1.	2019	University of Bergen [Best Image Award (Biomedical Image Contest @Department of Biomedicine)]
2.	2018	University of Bergen [Best Poster Award (Poster contest @Department of Biomedicine)]
3.	2018	K.G. Jebsen Center for Neuropsychiatric Disorders [Poster Prize (Annual Retreat 2018)]
4.	2013	International Society for Neurochemistry [Travel Award (The 24th Biennial Meeting of ISN-ASN]
5.	2011	International Society for Neurochemistry [Poster Prize (The 10th ISN Advanced School of N
6.	2011	International Society for Neurochemistry [Travel Award (The 23rd Biennial Meeting of ISN-ESN)]
7.	2010	International Society of Radiation Neurobiology [Travel Award (The 1st Annual Meeting of International Society of Radiatio
8.	2006	Brain Institute, Niigata University [Young Investigator Award (The 36th Niigata Summer Seminar for Neuroscience)]
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