Faculty Information - Kazuhisa Nakano

（Last updated : 2025-05-23 16:27:14）

Kazuhisa Nakano
Department Kawasaki Medical School Kawasaki Medical School, Department of Rheumatology,

Position Professor

■ Journal

1.	2025/02/26	Clinical Significance of Antinuclear Antibodies in Patients with　Rheumatoid Arthritis: From SETOUCHI-RA Registry
2.	2025/02/19	Case Report: Effective Management of Pulmonary Hypertension Associated With Takayasu Arteritis Through Both Immunosuppressive Therapy and Serial Balloon Pulmonary Angioplasty
3.	2024/03/21	Prognosis and prognostic factors of lung cancer complications in patients with rheumatoid arthritis
4.	2024/01/31	GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
5.	2023/10/03	Computed tomography for malignancy screening in patients with rheumatoid arthritis before initiation of disease modifying antirheumatic drug
6.	2022/11/15	Acromegaly: A Rare Cause of Knee Pain
7.	2022/09/16	Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression
8.	2022/07/22	TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1
9.	2022/05/14	IL-17A promotes vascular calcification in an ex vivo murine aorta culture
10.	2022/03/10	IL-17A promotes vascular calcification in an ex vivo murine aorta culture
11.	2022/03/04	Short-Term Prognostic Factors in Hospitalized Herpes Zoster Patients and Its Associated Cerebro-Cardiovascular Events: A Nationwide Retrospective Cohort in Japan
12.	2020/08/20	A case of systemic lupus erythematosus in which Cushing’s syndrome caused by adrenal adenoma accidentally occurred during long-term maintenance therapy with corticosteroids.
13.	2020/06/15	Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
14.	2020/06/08	Differential long-term retention of biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis by age group from the FIRST registry.
15.	2020/05/04	Two patients with mixed connective tissue disease complicated by pulmonary arterial hypertension showing contrasting responses to pulmonary vasodilators.
16.	2020/04/20	A case of bone destruction caused by chronic non-bacterial osteomyelitis (CNO) successfully repaired with a tumor necrosis factor-α (TNF-α) inhibitor, adalimumab.
17.	2020/03/27	Clinical aspects in patients with rheumatoid arthritis complicated with lymphoproliferative disorders without regression after methotrexate withdrawal and treatment for arthritis after regression of lymphoproliferative disorders.
18.	2020/03/12	Systemic lupus erythematosus with repeated protein-losing enteropathy resulting from different pathological conditions: a case report.
19.	2020/03/01	IgG4-type Multiple Myeloma with Diffuse Enlargement of the Thyroid Requiring Differentiation from IgG4-related Disease.
20.	2020/02/05	Correlation between serological biomarkers of extracellular matrix turnover and lung fibrosis and pulmonary artery hypertension in patients with systemic sclerosis.
21.	2020/02/05	The additive effects of hydroxychloroquine to maintenance therapy with standard of care in patients with systemic lupus erythematosus.
22.	2020/01/15	5-year remission rate after the discontinuation of adalimumab in patients with rheumatoid arthritis: Long-term follow-up results of the HONOR study.
23.	2020/01/07	2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases.
24.	2019/12/01	Distinctive association of peripheral immune cell phenotypes with capillaroscopic microvascular patterns in systemic sclerosis.
25.	2019/11/22	An autopsy case of a patient with systemic sclerosis who developed marked pulmonary hypertension becase of pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma.
26.	2019/10/19	Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial.
27.	2019/08/21	Focal Eosinophilic Myositis.
28.	2019/06/22	Comparative study of corticosteroid monotherapy, and TNF inhibitors with or without corticosteroid in patients with refractory entero-Behcet's disease.
29.	2019/06	IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2.
30.	2019/03/01	An Autopsy Case with Cerebral Hemorrhaging due to disseminated Aspergillosis During Glucocorticoid Therapy for Overlap Syndrome of Systemic Lupus Erythematosus and Systemic Sclerosis.
31.	2019/03	Effectiveness and safety of hydroxychloroquine therapy with or without corticosteroid in patients with systemic lupus erythematosus.
32.	2019/03	Type I and II interferons commit to abnormal expression of chemokine receptor on B cells in patients with systemic lupus erythematosus.
33.	2019/02/15	Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept.
34.	2019/02/01	Precision medicine using different biological DMARDs based on characteristic phenotypes of peripheral T helper cells in psoriatic arthritis.
35.	2019/02/01	Small Cell Lung Cancer Patient with Anti-transcriptional Intermediary Factor 1γ Antibody Who Developed Dermatomyositis after Successful Chemoradiotherapy.
36.	2019/01/09	The two cases of Acute acalculous cholecystitis associated with Systemic Lupus Erythematosus(SLE) presented different clinical aspects.
37.	2019/01/01	Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies.
38.	2018/12/10	Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis.
39.	2018/10/26	Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis.
40.	2018/08/28	Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.
41.	2018/08/01	IgG4-related Pleuritis with Elevated Adenosine Deaminase in Pleural Effusion: A Case Report.
42.	2018/06/01	Successful Management of Pregnancy in a Patient with Systemic Lupus Erythematosus-associated Pulmonary Arterial Hypertension.
43.	2018/06	A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab
44.	2018/06	Comparison of efficacy of TNF inhibitors and abatacept in patients with rheumatoid arthritis; Adjusted with propensity score matching.
45.	2018/06	Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC).
46.	2018/05/17	Successful treatment with etanercept in a case of seronegative rheumatoid arthritis with corticosteroid/methotrexate-resistant pemphigus erythematosus.
47.	2018/03/01	Correlation of T follicular helper cells and plasmablasts with the development of organ involvement in patients with IgG4-related disease.
48.	2018/01/01	Differential effects of biological DMARDs on peripheral immune cell phenotypes in patients with rheumatoid arthritis.
49.	2018	High level of adenosine deaminase in pleural effusion in patient with IgG4-related disease: A case report.
50.	2017/12	Relapsing Polychondritis Diagnosed by Fusion Images of Gallium-67 Uptake on Computed Tomography and Single-Photon-Emission Computed Tomography.
51.	2017/11/08	Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.
52.	2017/09/01	Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.
53.	2017	A case of rheumatoid arthritis treated with infliximab who developed disseminated Penicillium marneffei infection after visit to Thailand.
54.	2017	Peripheral immunophenotyping identifies three subgroups based on T cell heterogeneity in lupus patients.
55.	2017	The occurrence of hypertrophic pachymeningitis with infiltration of IgG4-positive plasma cells and with different aetiology: report of three cases.
56.	2016/08/31	Clinical, radiographic and functional efficacy of abatacept in routine care for rheumatoid arthritis patients: Abatacept Leading Trial for RA on Imaging Remission (ALTAIR) study.
57.	2016	Comparison of the efficacies of abatacept and tocilizumab in patients with rheumatoid arthritis by propensity score matching.
58.	2015/07/31	Histamine inhibits differentiateon of skin fibroblasts into myofibroblasts.
59.	2015/05	IL-6/STAT3 signaling pathway contributes to chondrogenic differentiation of human mesenchymal stem cells.
60.	2015/02	Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study.
61.	2014/05	Study on the safety and efficacy of tocilizumab, an anti-IL-6 receptor antibody, in patients with rheumatoid arthritis complicated with AA amyloidosis.
62.	2013/09/25	Discontinuation of adalimumab after attaining disease activity score 28-erythrocyte sedimentation rate remission in patients with rheumatoid arthritis (HONOR study): an observational study.
63.	2013/07	D1-like dopamine receptors antagonist inhibits cutaneous immune reactions mediated by Th2 and mast cells.
64.	2013/02/01	Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes.
65.	2013/01	DNA methylome signature in rheumatoid arthritis.
66.	2013	Dopamine D2-like receptor signaling suppresses human osteoclastogenesis.
67.	2012/10	Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway.
68.	2012/06	Amplification of Toll-like receptor-mediated signaling through spleen tyrosine kinase in human B-cell activation.
69.	2012	The JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-γ and IL-17 production by human CD4(+) T cells.
70.	2011/06	Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production.
71.	2011/06	Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice.
72.	2011/05/15	Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and ovalbumin antigen-induced neutrophilic airway inflammation.
73.	2011/03/15	Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model.
74.	2010/03	Tacrolimus, a calcineurin inhibitor, overcomes treatment unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory rheumatoid arthritis.
75.	2009/06	Dopamine released by dendritic cells polarizes Th2 differentiation.
76.	2008/08/22	Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis.
77.	2008/07/01	B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
78.	2008/02	Interaction of galectin-9 with lipid rafts induces osteoblast proliferation through the c-Src/ERK signaling pathway.
79.	2007/06/29	Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities.
80.	2007/05	Activation signal transduction by beta1 integrin in T cells from patients with systemic lupus erythematosus.
81.	2007/04	Rheumatoid synovial endothelial cells produce macrophage colony-stimulating factor leading to osteoclastogenesis in rheumatoid arthritis.
82.	2007/01	Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death.
83.	2005/06	Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus.
84.	2004/12	Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytes.
85.	2004/08	Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts.
86.	2004/07	Macrophage inflammatory protein-1alpha induces hypercalcemia in adult T-cell leukemia.
87.	2004	Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility.
88.	2003/03/27	Crosslinking of CD44 on human osteoblastic cells upregulates ICAM-1 and VCAM-1.
89.	2001/06	Multiple hepatic infarction after transcatheter arterial infusion with SMANCS.
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■ Presentation

1.	2025/04/25	Clinical Relevance of Radial and Ulnar Artery Diameter Measurement Using Vascular Ultrasonography in Patients with Systemic Sclerosis （Speech，General）
2.	2021/12/08	The investigation of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models （Poster notice，General）
3.	2021/08/28	The study of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models （Speech，General）