日本語 >>
TOP page
Current specialization
Journal Articles
Presentations
Professional Organizations
（Last updated : 2026-07-09 16:31:26）
Keisuke Kitakaze
Department
Kawasaki Medical School Kawasaki Medical School, Department of Pharmacology,
Position
Instructor
■
Current specialization
Pharmacology, Pharmaceutical hygiene and biochemistry
■
Journal Articles
1.
2026/04/22
AAV-based gene therapy with modified
HEXB
confers lasting therapeutic benefits in GM2 gangliosidosis models
2.
2025/09/29
Questionnaire survey on the educational effectiveness of the medical student laboratory assignment program
3.
2025/04/18
N
-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I
4.
2024/07/22
GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
5.
2024/03/22
Sweat protects against contact hypersensitivity: Transient sweat suppression compromises skin barrier function in mice
6.
2023/05/16
GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator.
7.
2022/12/25
A simple enzyme assay for glycerophosphodiesterase GDE4 and GDE7 using fluorescent substrate
8.
2022/01/08
Coculture
in vitro
with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner
9.
2021/10/18
Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7.
10.
2021/09/28
Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation.
11.
2021/09/20
ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model.
12.
2021/05/24
Involvement of acid ceramidase in the degradation of bioactive
N
-acylethanolamines.
13.
2020/06
Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts.
14.
2019/12
Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity.
15.
2016/09
Combined replacement effects of human modified beta-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.
16.
2016/09
Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues that Allows Facile Access to Protein Library.
17.
2016/05
Protease-resistant modified human beta-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
18.
2015/08
Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System.
19.
2015/05
The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.
20.
2013/07
Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide.
21.
2011/12
Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.
22.
2011/06
Therapeutic potential of intracerebroventricular replacement of modified human beta-hexosaminidase B for GM2 gangliosidosis.
Display 5 items
Display all(22)
■
Presentations
1.
2026/07/15
Analysis of lipid phosphate phosphatase 3 in pulmonary fibrosis （Poster notice，General）
2.
2026/07/14
GPR176 modulates fibroblast metabolism and confers resistance to ferroptosis （Poster notice，General）
3.
2025/07/25
The Educational Effects of Kawasaki Medical School’s Research Laboratory Placement Program （Poster notice，General）
4.
2024/11/06
GPR176/Gz signaling is involved in fibroblast activation via the TGFβ1/Smads/αSMA pathway （Poster notice，General）
5.
2024/11/06
Analysis for the specificity of fluorescent substrates for acid ceramidase （Poster notice，General）
6.
2024/11/06
Investigation of the role of senescent cells in pulmonary fibrosis using p16-conditional knockout mice （Poster notice，General）
7.
2024/11/06
Functional analyses of glycerophosphodiesterase GDE4 in a prostate cancer cell line （Poster notice，General）
8.
2023/03/14
Mechanism of decreased expression of the lipid mediator-degrading enzyme in fibrotic lung （Poster notice，General）
9.
2022/11/11
Glycerophosphodiesterase 7 produces cyclic phosphatidic acid in the ER lumen （Poster notice，General）
10.
2022/11/11
Role of senescent alveolar epithelial cells in pulmonary fibrosis （Poster notice，General）
11.
2022/06/26
Acid ceramidase as a third
N
-acylethanolamine hydrolase in cells and tissues （Poster notice，General）
12.
2022/03/28
Hydrolysis of anti-inflammatory and anorexic
N
-acylethanolamines by acid ceramidase as revealed by using saposin D-deficient mice （Poster notice，General）
13.
2022/03/08
Development of a simple assay to measure glycerophosphodiesterase GDE4 and GDE7 activities for screening their Inhibitors （Poster notice，General）
14.
2022/03/08
The crosstalk between Il-4/IL-13 and S1P/S1P
2
signaling in phorbol ester-treated THP-1 MΦs （Poster notice，General）
15.
2022/03/08
Hydrolytic activity of acid ceramidase on
N
-acylethanolamines, anti-inflammatory and anorexic lipid mediators: an analysis using saposin D-knockout mice （Poster notice，General）
16.
2022/03/07
Analysis of the role of macrophage senescence in lung fibrosis using macrophage-specific p16 knockout mice （Poster notice，General）
17.
2021/11/03
Fluorescence-based enzyme activity assay for glycerophosphodiesterase GDE4 and GDE7 （Poster notice，General）
18.
2021/11/03
The effect of p16 overexpression on gene expression of fibrosis-related factors in alveolar epithelial cells and macrophages （Poster notice，General）
19.
2021/11/03
Analysis of
N
-acylethanolamine-hydrolyzing activity using saposin D-deficient mice （Poster notice，General）
20.
2021/11/03
S1P
2
-Rho kinase pathway is necessary for full activation of STAT6 by IL-4/IL-13 in THP-1 macrophages （Poster notice，General）
21.
2021/04/27
The role of sphingosine 1-phosphate type 2 receptor on IL-4/IL-13-stimulated STAT6 phosphorylation in phorbol12-myristate13-acetate-treated THP-1 cells （Poster notice，General）
22.
2021/04/27
Growth differentiation factor 15 activates macrophages and fibroblasts （Poster notice，General）
23.
2021/04/27
Role of acid ceramidase in the hydrolysis of anti-inflammatory and anorexic
N
-acylethanolamines （Poster notice，General）
24.
2021/04/27
Identification of a chemical chaperone for mitigating protein aggregation and proteotoxicity during endoplasmic reticulum stress （Poster notice，General）
25.
2021/03/29
Changes in expression of fibrosis-related factors in p16 forced-expression cells （Poster notice，General）
26.
2021/03/09
Transcription factor ATF4 maintains pancreatic β-cell identity during ER stress （Speech，General）
27.
2021/03/08
The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13-induced STAT6 phosphorylation in phorbol 12-myristate 13-acetate-stimulated THP-1 cells （Poster notice，General）
28.
2021/03/08
Changes in expression of fibrosis-related factors in alveolar epithelial cells and macrophages by forced expression of p16 （Poster notice，General）
29.
2020/03/17
Altered gene expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal interstitial fibrosis in mice. （General）
30.
2020/03/17
Identification of a chemical chaperone for preventing protein aggregation and proteotoxicity under endoplasmic reticulum stress （Abstract Only，General）
31.
2019/09/19
Identification of a chemical chaperone for preventing protein aggregation under ER stress （Speech，General）
32.
2019/06/19
Expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal fibrosis in mice. （Poster notice，General）
33.
2018/06
Targeted deletion of ATF4 in beta-cells leads to the vulnerability and dedifferentiation during ER stress （Poster notice，General）
34.
2015/02
Development of Protease-Resistant Modified Human beta-Hexosaminidase B and Evaluation of Intracerebroventricular replacement Effects on Gm2 Gangliosidosis Model Mice （Speech，General）
35.
2014/08
SYNTHETIC STUDY OF GM2 ACTIVATOR PROTEIN USING N-SULFANYLETHYLANILIDE PEPTIDE （Poster notice，General）
36.
2014/02
Replacement effects of human modified lysosomal beta-hexosaminidase B on Tay-Sachs disease and Sandhoff disease models and imaging with novel pH-activatable fluorescent probes （Speech，General）
37.
2014/01
Replacement Effects of Human Modified Lysosomal beta-hexosaminidase B on Tay-Sachs and Sandhoff Disease Models and Imaging with Novel pH-activatable Fluorescent Probes （Poster notice，General）
38.
2013/11
Development of chemical protocol for preparation of peptide/protein thioesters applicable to naturally occurring sequences （Poster notice，General）
39.
2013/04
Evaluation of enzyme replacement effects and development of purification system to obtain recombinant lysosomal enzyme carrying M6P-type glycans （Poster notice，General）
40.
2012/06
Vital imaging of endocytosed lysosomal enzymes with pH-activatable fluorescent probe and evaluation of enzyme replacement effects on lysosomal storage diseases （Poster notice，General）
Display 5 items
Display all(40)
■
Professional Organizations
1.
The Japanese Pharmacological Society
2.
THE JAPANESE BIOCHEMICAL SOCIETY
3.
Japan Society of Gene and Cell Therapy
