Faculty Information - Keisuke Kitakaze

（Last updated : 2024-11-13 15:58:36）

Keisuke Kitakaze
Department Kawasaki Medical School Kawasaki Medical School, Department of Pharmacology,

Position Instructor

■ Present specialized field

Pharmacology, Pharmaceutical hygiene and biochemistry, Nutrition science and health science, Respiratory medicine, General internal medicine, Psychiatry

■ Journal

1.	2024/07/22	GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
2.	2024/03/22	Sweat protects against contact hypersensitivity: Transient sweat suppression compromises skin barrier function in mice
3.	2023/05/16	GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator.
4.	2022/12/25	A simple enzyme assay for glycerophosphodiesterase GDE4 and GDE7 using fluorescent substrate
5.	2022/01/08	Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner
6.	2021/10/18	Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7.
7.	2021/09/28	Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation.
8.	2021/09/20	ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model.
9.	2021/05/24	Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines.
10.	2020/06	Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts.
11.	2019/12	Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity.
12.	2016/09	Combined replacement effects of human modified beta-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.
13.	2016/09	Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues that Allows Facile Access to Protein Library.
14.	2016/05	Protease-resistant modified human beta-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.
15.	2015/08	Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System.
16.	2015/05	The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.
17.	2013/07	Chemical synthesis of biologically active monoglycosylated GM2-activator protein analogue using N-sulfanylethylanilide peptide.
18.	2011/12	Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.
19.	2011/06	Therapeutic potential of intracerebroventricular replacement of modified human beta-hexosaminidase B for GM2 gangliosidosis.
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■ Presentation

1.	2024/11/06	GPR176/Gz signaling is involved in fibroblast activation via the TGFβ1/Smads/αSMA pathway （Poster notice，General）
2.	2024/11/06	Analysis for the specificity of fluorescent substrates for acid ceramidase （Poster notice，General）
3.	2024/11/06	Investigation of the role of senescent cells in pulmonary fibrosis using p16-conditional knockout mice （Poster notice，General）
4.	2024/11/06	Functional analyses of glycerophosphodiesterase GDE4 in a prostate cancer cell line （Poster notice，General）
5.	2023/03/14	Mechanism of decreased expression of the lipid mediator-degrading enzyme in fibrotic lung （Poster notice，General）
6.	2022/11/11	Glycerophosphodiesterase 7 produces cyclic phosphatidic acid in the ER lumen （Poster notice，General）
7.	2022/11/11	Role of senescent alveolar epithelial cells in pulmonary fibrosis （Poster notice，General）
8.	2022/06/26	Acid ceramidase as a third N-acylethanolamine hydrolase in cells and tissues （Poster notice，General）
9.	2022/03/28	Hydrolysis of anti-inflammatory and anorexic N-acylethanolamines by acid ceramidase as revealed by using saposin D-deficient mice （Poster notice，General）
10.	2022/03/08	Development of a simple assay to measure glycerophosphodiesterase GDE4 and GDE7 activities for screening their Inhibitors （Poster notice，General）
11.	2022/03/08	The crosstalk between Il-4/IL-13 and S1P/S1P₂ signaling in phorbol ester-treated THP-1 MΦs （Poster notice，General）
12.	2022/03/08	Hydrolytic activity of acid ceramidase on N-acylethanolamines, anti-inflammatory and anorexic lipid mediators: an analysis using saposin D-knockout mice （Poster notice，General）
13.	2022/03/07	Analysis of the role of macrophage senescence in lung fibrosis using macrophage-specific p16 knockout mice （Poster notice，General）
14.	2021/11/03	Fluorescence-based enzyme activity assay for glycerophosphodiesterase GDE4 and GDE7 （Poster notice，General）
15.	2021/11/03	The effect of p16 overexpression on gene expression of fibrosis-related factors in alveolar epithelial cells and macrophages （Poster notice，General）
16.	2021/11/03	Analysis of N-acylethanolamine-hydrolyzing activity using saposin D-deficient mice （Poster notice，General）
17.	2021/11/03	S1P₂-Rho kinase pathway is necessary for full activation of STAT6 by IL-4/IL-13 in THP-1 macrophages （Poster notice，General）
18.	2021/04/27	The role of sphingosine 1-phosphate type 2 receptor on IL-4/IL-13-stimulated STAT6 phosphorylation in phorbol12-myristate13-acetate-treated THP-1 cells （Poster notice，General）
19.	2021/04/27	Growth differentiation factor 15 activates macrophages and fibroblasts （Poster notice，General）
20.	2021/04/27	Role of acid ceramidase in the hydrolysis of anti-inflammatory and anorexic N-acylethanolamines （Poster notice，General）
21.	2021/04/27	Identification of a chemical chaperone for mitigating protein aggregation and proteotoxicity during endoplasmic reticulum stress （Poster notice，General）
22.	2021/03/29	Changes in expression of fibrosis-related factors in p16 forced-expression cells （Poster notice，General）
23.	2021/03/09	Transcription factor ATF4 maintains pancreatic β-cell identity during ER stress （Speech，General）
24.	2021/03/08	The role of sphingosine 1-phosphate receptor 2 on interleukin (IL)-4/IL-13-induced STAT6 phosphorylation in phorbol 12-myristate 13-acetate-stimulated THP-1 cells （Poster notice，General）
25.	2021/03/08	Changes in expression of fibrosis-related factors in alveolar epithelial cells and macrophages by forced expression of p16 （Poster notice，General）
26.	2020/03/17	Altered gene expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal interstitial fibrosis in mice. （General）
27.	2020/03/17	Identification of a chemical chaperone for preventing protein aggregation and proteotoxicity under endoplasmic reticulum stress （Abstract Only，General）
28.	2019/09/19	Identification of a chemical chaperone for preventing protein aggregation under ER stress （Speech，General）
29.	2019/06/19	Expression of lysophosphatidic acid receptor subtypes in ischemia/reperfusion-induced renal fibrosis in mice. （Poster notice，General）
30.	2018/06	Targeted deletion of ATF4 in beta-cells leads to the vulnerability and dedifferentiation during ER stress （Poster notice，General）
31.	2015/02	Development of Protease-Resistant Modified Human beta-Hexosaminidase B and Evaluation of Intracerebroventricular replacement Effects on Gm2 Gangliosidosis Model Mice （Speech，General）
32.	2014/08	SYNTHETIC STUDY OF GM2 ACTIVATOR PROTEIN USING N-SULFANYLETHYLANILIDE PEPTIDE （Poster notice，General）
33.	2014/02	Replacement effects of human modified lysosomal beta-hexosaminidase B on Tay-Sachs disease and Sandhoff disease models and imaging with novel pH-activatable fluorescent probes （Speech，General）
34.	2014/01	Replacement Effects of Human Modified Lysosomal beta-hexosaminidase B on Tay-Sachs and Sandhoff Disease Models and Imaging with Novel pH-activatable Fluorescent Probes （Poster notice，General）
35.	2013/11	Development of chemical protocol for preparation of peptide/protein thioesters applicable to naturally occurring sequences （Poster notice，General）
36.	2013/04	Evaluation of enzyme replacement effects and development of purification system to obtain recombinant lysosomal enzyme carrying M6P-type glycans （Poster notice，General）
37.	2012/06	Vital imaging of endocytosed lysosomal enzymes with pH-activatable fluorescent probe and evaluation of enzyme replacement effects on lysosomal storage diseases （Poster notice，General）
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■ Belonging society

1.		The Japanese Pharmacological Society
2.		THE JAPANESE BIOCHEMICAL SOCIETY