Faculty Information - Seiji Kishi

（Last updated : 2025-03-04 10:37:25）

Seiji Kishi
Department Kawasaki Medical School Kawasaki Medical School, Department of Nephrology and Hypertension,

Position Associate Professor with Special Assignment

■ Journal

1.	2024/09	Treatment of chronic kidney disease in older populations
2.	2024/08	Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease
3.	2024/02	Oxidative stress and the role of redox signalling in chronic kidney disease
4.	2024/01/09	A case series of Fabry diseases with CKD in Japan.
5.	2023/12/19	IL-1β may be an indicator of peritoneal deterioration after healing of peritoneal dialysis-associated peritonitis
6.	2023/10/01	Insights into the regulation of glomerular filtration rate by the Keap1-Nrf2 pathway
7.	2023/10	Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.
8.	2023/09	Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis
9.	2023/09	Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis.
10.	2023/06	The Impact of Potassium Binders on Mortality in Patients with Hyperkalemia: A Single-Center Study
11.	2023	The deficient of eNOS-NO pathway exacerbates kidney dysfunction via inflammasome activation in diabetic kidney disease
12.	2022/08	The novel preventive effect of a Japanese ethical Kampo extract formulation TJ-90 (Seihaito) against cisplatin-induced nephrotoxicity.
13.	2022/01/25	Current Issues in AKI Research and Perspectives for Future Therapies
14.	2021/10/05	Prescription Patterns of Antimicrobial Agents for Upper Respiratory Tract Infections in Patients Visiting the Emergency Department of Kawasaki Medical School Hospital: A Descriptive Study
15.	2021/05	KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease.
16.	2021/04	Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity.
17.	2021/02	Human reconstructed kidney models
18.	2020/12	Case of septic pulmonary embolism derived from mitral valve endocarditis in a patient with end-stage kidney disease at the initiation period of hemodialysis.
19.	2020	Clinical characteristics associated with 1-year tolvaptan efficacy in autosomal dominant polycystic kidney disease with a wide range of kidney functions.
20.	2020	KIM-1 Mediated Tubular Fatty Acid Uptake Leads to Progressive Diabetic Kidney Disease
21.	2019/10/07	Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses.
22.	2019/10	Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism.
23.	2019/09/06	Clinical evaluation of presepsin considering renal function.
24.	2019/03	All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element.
25.	2019/02	Direct oral anticoagulant successfully used to treat an adult nephrotic patient complicated with portal vein thrombosis.
26.	2019/01	Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair.
27.	2019	Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy.
28.	2019	The utility and limitation of inferior vena cava diameter as a dry weight marker.
29.	2018/12	Lambda Light Chain Non-crystalline Proximal Tubulopathy with IgD Lambda Myeloma.
30.	2018/11	A Case of Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.
31.	2018/08	An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury.
32.	2018/07	Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy.
33.	2018/05	IgA Nephropathy after Nivolumab Therapy for Postoperative Recurrence of Lung Squamous Cell Carcinoma.
34.	2018/05	Urinary IgG4 and Smad1 Are Specific Biomarkers for Renal Structural and Functional Changes in Early Stages of Diabetic Nephropathy.
35.	2018/04	Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study.
36.	2018	Urinary Exosomal mRNA of WT1 as Diagnostic and Prognostic Biomarker for Diabetic Nephropathy.
37.	2017/10	Mesangial Cell Mammalian Target of Rapamycin Complex 1 Activation Results in Mesangial Expansion.
38.	2017/09	Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice.
39.	2017/08	Re-recognition of Age-dependent Reference Range for the Serum Creatinine Level in Teenagers - A Case of Slowly Progressive Tubulointerstitial Nephritis which Occurred in an Adolescent.
40.	2017/08	Successful treatment of highly advanced immunoglobulin G4-related kidney disease presenting renal mass-like regions with end-stage kidney failure: a case study.
41.	2017/05	A case of rapid amelioration of hepatitis C virus-associated cryoglobulinemic membranoproliferative glomerulonephritis treated by interferon-free directly acting antivirals for HCV in the absence of immunosuppressant.
42.	2017/05	Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation.
43.	2017/03	Shunt Nephritis and Pyogenic Spondylitis With a Positive PR3-ANCA Associated With Chronically Infected Ventriculoatrial Shunt.
44.	2017	A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis.
45.	2017	Influential factors on serum albumin concentration in hospitalized chronic kidney disease patients.
46.	2015/11	Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
47.	2015/08	Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy.
48.	2015/07	Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury.
49.	2013/12	Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients.
50.	2013/06	Dual involvement of growth arrest-specific gene 6 in the early phase of human IgA nephropathy.
51.	2012/08	Acute glomerulonephritis in an immunocompetent elderly woman after contact with a child who had been diagnosed as erythema infectiosum.
52.	2012/06	Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1 protein-smooth muscle alpha-actin (SMA) signal transduction in diabetic nephropathy.
53.	2012/04	A case of traumatic intracranial vertebral artery injury presenting with life-threatening symptoms.
54.	2011/09	SOX9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy.
55.	2011/06	Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy.
56.	2011/05	[Discussion meeting on recent progress of systemic diseases in chronic kidney disease].
57.	2011	An autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with intestinal bleeding in chronic renal failure.
58.	2011	MPO-ANCA-positive anti-glomerular basement membrane antibody disease successfully treated by plasma exchange and immunosuppressive therapy.
59.	2010/10	Successful management of refractory pleural effusion due to systemic immunoglobulin light chain amyloidosis by vincristine adriamycin dexamethasone chemotherapy: a case report.
60.	2010/09	Transcription factor 7-like 2 (TCF7L2) regulates activin receptor-like kinase 1 (ALK1)/Smad1 pathway for development of diabetic nephropathy.
61.	2010/05	Early Diagnosis and treatment may Prevent the Development of Complications in an Adult Patient with Glycogen Storage Disease Type Ia
62.	2010	Trophoblast glycoprotein: possible candidate mediating podocyte injuries in glomerulonephritis.
63.	2009	Angio-embolization of renal artery pseudoaneurysm after renal biopsy: a case report.
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■ Presentation

1.	2024/05/23	Investigating the effects of low-level and transient DNA damage on kidney health in a novel mouse model of aging （Poster notice，General）
2.	2023/11/03	Association of Serum Magnesium Concentration with Renal Prognosis in Patients with CKD （Poster notice，General）
3.	2023/11/02	Elucidation of the Molecular Mechanism of Albuminuria Improvement by Nonsteroidal Mineralocorticoid Receptor (MR) Antagonists Focusing on Podocyte Calcium (Ca2+) Dynamics （Poster notice，General）
4.	2022/10/22	Dual Disruption of Endothelial Nitric Oxide Synthase and ApoE Gene Accelerates Kidney Fibrosis and Aging After Injury （Poster notice，General）
5.	2022/10/15	A case of septic pulmonary embolism due to mitral valve endocarditis occurring early in the induction phase of hemodialysis （Poster notice，General）
6.	2022/10/15	eNOS/NO signaling regulates renal interstitial fibrosis by increasing cytoplasmic beta-catenin degradation （Poster notice，General）
7.	2020/10/19	eNOS/NO Signaling Attenuates Progression of Age-Related Kidney Diseases via Suppression of Inflammasome. （Poster notice，General）
8.	2020/08/19	Role of the DNA damage response in kidney tubular epithelial cells on acute kidney injury and subsequent CKD transition （Speech，Panelist at Symposium/Workshop (Appointed)）
9.	2019/11/09	Cyclin G1-Mediated Dedifferentiation of Proximal Tubular Cells Dreves Fibrosis （Poster notice）
10.	2019/11/08	A Novel All-Trans Retinoic Acid Therapy Directly Suppresses Bone Morphogenetic Protein 4 in Mouse Diabetic Nephropathy （Poster notice）
11.	2019/11/08	ATR Deletion Drives TOR-Autophagy Spatial Coupling Compartment（TASCC）Formation and Kidney Fibrosis （Speech）
12.	2019/11/08	Proximal Tubular Uptake of Free Fatty Acid（FFA）by Kidney Injury Molecule-1（KIM-1）Mediates Tubulointerstitial Damage in Diabetic Kidney Disease（DKD）,Which Is Attenuated by a Novel Inhibitor （Speech）
13.	2019/11/07	Dual Disruption of Endothelial Nitric Oxide Synthase and ApoE Gene Accelerates Kidney Fibrosis and Aging After Injury （Poster notice）
14.	2018/10/27	Glomerular Injury Related to Immune Related Adverse Events: IgA Nephropathy After Nivolumab Therapy for Postoperative Recurrence of Lung Cancer （Poster notice，General）
15.	2018/10/25	Proximal Tubule ATR in Humans and Mice Is a Key Regulator of the DNA Repair Response Protecting the Kidney Against Maladaptive Repair and Fibrosis After Tubular Injury （Poster notice，General）
16.	2018/06/08	Disruption of genome maintenance mechanisms in renal proximal tubular epithelial cells exacerbates kidney fibrosis （Speech，General）
17.	2017/11/03	Disruption of genome maintenance mechanisms in renal proximal tubular epithelial cells exacerbates human kidney fibrosis （Poster notice，General）
18.	2017/11/03	Glomerulosclerosis Attenuated by Retinoic Acid through Bone Morphogenetic Protein 4 Suppression in Mice with Streptozotocin-Induced Diabetes （Poster notice，General）
19.	2017/11/03	Palovarotene, Selective Retinoic Receptor- Agonist, Inhibited Both BMP4 and TGF- Signaling Pathways in Diabetic Nephropathy （Poster notice，General）
20.	2016/11/19	In vivo evidence of mTORC1-S6 kinase pathway involvement in the development of glomerulosclerosis in human IgA nephropathy （Poster notice，General）
21.	2016/11/19	Shunt Nephritis And Pyogenic Spondylitis With A Positive PR3-ANCA Associated With Chronically Infected Ventriculo-Arterial Shunt （Poster notice，General）
22.	2016/11/17	Expression of Endomucin, an Endothelial-Specific Sialomucin in Normal and Injured Kidneys （Poster notice，General）
23.	2016/11/17	The Role of BMP4 Signal Pathway on the Podocyte Injury in Diabetic Early Stage （Poster notice，General）
24.	2016/09/19	Genome homeostasis of renal proximal tubule cell determines the outcome of kidney disease （Speech，General）
25.	2016/08/20	Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury （Speech，Special/Invited Lecture）
26.	2015/11/07	Deletion of ATR, a Master Molecule of DNA Damage Response, in the Proximal Tubule Exacerbates Kidney Injury and Increases Fibrosis （Poster notice，General）
27.	2015/11/07	Multi-Segmented Nephron Organoids Derived from Human Pluripotent Stem Cells Model Kidney Development and injury （Speech，General）
28.	2014/10/01	An Old drug Meclizine' may offer new treatment options for Ischemic Kidney Injury （Speech，Special/Invited Lecture）
29.	2013/11/05	Meclizine Preconditioning Protects against Ischemic Kidney Injury （Poster notice，General）
30.	2012/12/15	Role of BMP4 for regulating podocyte injury in the diabetic nephropathy. （Poster notice，General）
31.	2012/11/01	Expression of Gas6 and Axl in Human IgA Nephropathy. ~A Possible Involvement of Gas6 in Podocyte Injury~ （Poster notice，General）
32.	2012/06	BMP4 regulates podocyte injury in the diabetic nephropathy （Speech，General）
33.	2011/12/03	SOX9 induces irreversible chondrogenic phenotypic change in diabetic nephropathy （Poster notice，General）
34.	2011/12	BMP4 regulates podocyte injury in the diabetic nephropathy （Speech，General）
35.	2011/11	BMP4 regulates podocyte injury in the diabetic nephropathy （Poster notice，General）
36.	2010/12	Chondrogenic phenotypic change contributes to the irreversible progression of the diabetic nephropathy. （Poster notice，General）
37.	2009/12	Chondrogenic Potential of Mesangial Cells in Diabetic Nephropathy （Poster notice，General）
38.	2009/11	The Novel Function of Trophoblast Glycoprotein(Tpbg) on Actin Remodeling in Podocyte Injured in Experimental Glomerulonephritis2009 （Poster notice，General）
39.	2009/06	TCF7L2(Transcription factor 7-like 2) Regulates Activin Receptor-Like Kinase1(ALK1)/ Smad1 Pathway for Development of Diabetic Nephropathy.(Araoka T : Young Investigator Travel Grant Award)2009 （Speech，General）
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■ Belonging society

2018/03～

∟ FACP