Faculty Information - Masanori Iseki

（Last updated : 2026-01-22 09:54:07）

Masanori Iseki
Department Kawasaki Medical School Kawasaki Medical School, Department of Immunology and Molecular Genetics,

Position Assistant Professor

■ Present specialized field

Immunology

■ Journal

1.	2025/11/21	Endothelial dysfunction accelerates AKI to CKD transition by promoting β-catenin activation in macrophages
2.	2025/10/28	Partially hydrolyzed guar gum intake alleviates lipopolysaccharide-induced systemic inflammation via gut microbial alteration in mice
3.	2025/07/18	Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice
4.	2025/01/29	Epstein-Barr virus induced 3 attributes to TLR7-mediated splenomegaly
5.	2024/08/01	Control of germinal center B cell survival and IgE production by an adaptor molecule containing PH and SH2 domains, Aps/Sh2b2
6.	2023/08/14	Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model
7.	2022/07/22	TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1
8.	2022/04/13	Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation
9.	2021/11/07	Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model
10.	2021/04/17	SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.
11.	2019/08	Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor-associated periodic syndrome
12.	2019/06	IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis
13.	2019/04	Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Fas^lpr Mice.
14.	2018/01	Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation.
15.	2014/08	Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-gamma-producing T cells.
16.	2014/06	Lnk prevents inflammatory CD8⁺ T-cell proliferation and contributes to intestinal homeostasis.
17.	2013/11	TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice.
18.	2012/03	Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4⁺ T cells and IL-4.
19.	2010/03	Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses.
20.	2008/10	Cutting edge: Inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor.
21.	2007/05	Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
22.	2006/05	Differential Role of SH2-B and APS in Regulating Energy and Glucose Homeostasis
23.	2006/04	Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.
24.	2005/05	APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation.
25.	2004/03	Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains.
26.	2004/03	Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly
27.	2003/11	Increased insulin sensitivity and hypoinsulinemia in APS knockout mice.
28.	2002/05	SH2-B is required for both male and female reproduction.
29.	2000/05	Molecular Cloning of the Mouse APS as a Member of the Lnk Family Adaptor Proteins
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■ Presentation

1.	2025/12/12	Functional analysis of UBA1 mutations responsible for VEXAS syndrome （Poster notice，General）
2.	2025/12/10	The cytokine component Epstein-Barr virus-induced 3 (EBI3) is involved in splenomegaly induced by TLR7 stimulation （Poster notice，General）
3.	2025/04/26	Exploring the Role of EBI3 and IL-27 in Imiquimod-induced Splenomegaly （Poster notice，General）
4.	2024/12/05	Control of IgE production and germinal center B cell survival by Aps/Sh2b2, a member of Lnk-family adaptor proteins （Speech，General）
5.	2024/09/04	Therapeutic Effects of GLP-1 Agonist on Psoriasis in Obese Mice （Poster notice，General）
6.	2024/07/15	Diet-induced differences in gut microbiota determine the responder or non-responder of traditional herbal medicine. （Poster notice，General）
7.	2023/12/08	Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis in a murine model （Poster notice，General）
8.	2023/12/07	Epstein-Barr virus induced 3 (EBI3), a component of heterodimer cytokine, promotes TLR7-induced inflammatory disease. （Poster notice，General）
9.	2023/05/10	Accompanying non-alcoholic steatohepatitis exacerbates psoriasis in a murine model （Poster notice，General）
10.	2022/12/08	Single-cell RNA-sequencing of the synovial cells in gp130F759, a murine rheumatoid arthritis model, revealed changes in B-cell repertoire at the transitional phase from innate to acquired immunity （Poster notice，General）
11.	2022/09/23	The diet-induced differences in gut microbiota determines the responder / non-responder of Daiokanzoto （Speech，General）
12.	2022/07/07	Study of relationship between responders and non-responders to action of Kampo medicines via gut microbiota （Speech，General）
13.	2022/04/27	Obesity and hyperlipidemia synergistically exacerbate psoriatic skin inflammation （General）
14.	2021/05/10	Lack of bone marrow stromal cell antigen-1 (BST-1)/CD157 ameliorated colitis induced by dextran sodium sulfate (DSS) （Poster notice，General）
15.	2020/12/04	BST-1/CD157 promotes epithelial damages in DSS-induced colitis. （Poster notice，General）
16.	2020/12/04	Lack of BST-1/CD157 ameliorated fibroblastic changes of arthritis in GP130F759 through down regulation of IL-6 production by synovial fibroblasts. （Poster notice，General）
17.	2020/12/04	The role of an adaptor protein SH3BP2 in the pathogenesis of systemic lupus erythematosus （Poster notice，General）
18.	2020/11/07	SH3BP2 Deciency Ameliorates Murine Systemic Lupus Erythematosus （Poster notice，General）
19.	2020/10/24	SH3BP2 deficiency ameliorates murine systemic lupus erythematosus （Poster notice，General）
20.	2020/08/17	IL-6-PAD4 axis in the preclinical state of the synovium in gp130F759 -interaction between fibroblast-like synoviocytes and neutrophils- （Speech，General）
21.	2020/07/08	全身性エリテマトーデスモデルマウスにおけるアダプター蛋白SH3BP2 の自己免疫現象における役割の解明（Poster notice，General）
22.	2019/12/13	IL-6-PAD4 axis: IL-6 dependent PAD4 production in neutrophils at the earliest phase of arthritis in gp130F759. （Poster notice，General）
23.	2019/12/11	Toll-like receptor-induced Ab production from marginal zone B cells is negatively regulated by ADP-ribosyl cyclase BST-1/CD157 （Poster notice，General）
24.	2019/11/10	The role of adopter protein SH3BP2 in a murine systemic lupus erythematosus model （Poster notice，General）
25.	2019/11/10	The Study of the Novel G87V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS) （Poster notice，General）
26.	2019/06/06	CX3CR1-eGFP⁺ macrophage-like synoviocytes in gp130F759, a mouse model for rheumatoid arthritis （Poster notice，General）
27.	2019/04/17	SH3BP2 gain-of-function mutation ameliorates lupus in B6.MRL-Faslpr mice （Speech，General）
28.	2019/04/16	The Study of the novel G58V mutation in the TNFRSF1A gene identified in a family with TNF Receptor-Associated Periodic Syndrome(TRAPS) （Speech，General）
29.	2018/12/12	BST-1/CD157 negatively regulates marginal zone B cell survival and Ab production induced with Toll-like receptor stimulation （Poster notice，General）
30.	2018/12/12	Deletion of padi4 exacerbated the arthritis in gp130F759. （Poster notice，General）
31.	2018/12/11	Elongation of the small intestine and enlargement of the mesenteric lymph nodes in Bst1Cd38 double knockout mice. （Poster notice，General）
32.	2018/10/21	The novel G58V mutation in the TNFRSF1A gene identified in a family with TNF Receptor-Associated Periodic Syndrome (TRAPS) decreases the cell surface expression of TNFR1 （Poster notice，General）
33.	2018/05/06	A novel function of ADP-ribosyl cyclases to regulate the length of the small intestine revealed in CD38/CD157 double knockout mice （Speech，General）
34.	2018/05/04	Accelerated onset of arthritis by systemic infection of Mycoplasma fermentans in the knock-in mice gp130F759 （Poster notice，General）
35.	2018/04/27	SH3BP2 gain-of-function mutation alleviates lupus phenotypes in B6.MRL-Faslpr mice （Speech，General）
36.	2018/04/26	Functional analysis of the novel G58V mutation in the TNFRSF1A gene identified in a family with TNF receptor-associated periodic syndrome(TRAPS) （Speech，General）
37.	2017/12/12	BST-1/CD157 on B cells negatively regulates Toll-like receptor signaling （Poster notice，General）
38.	2017/11/07	SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice （Poster notice，General）
39.	2017/11/05	Functional Analysis of the Novel G58V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS) （Poster notice，General）
40.	2016/12/05	Lack of microbiota revealed the role for BST-1/CD157 to maintain the homeostasis at mucosa-MLN interface （Poster notice，General）
41.	2015/11/20	Germinal center B cell survival and optimal IgE production are controled by Lnk/Sh2b family adaptor protein Aps/Sh2b2. （Speech，General）
42.	2014/12/11	Lnk/Sh2b family adaptor protein Aps/Sh2b2 in B cells contributes to germinal center B cell survival and optimal IgE production in vivo. （Poster notice，General）
43.	2014/12/10	Lnk/Sh2b3 adaptor protein controls cytokine responses of dendritic cells, and regulates the induction of IFN-gamma-producing T cells. （Poster notice，General）
44.	2013/12/13	IgE production and germinal center formation are regulated by the adaptor protein Aps/Sh2b2 in B cells. （Speech，General）
45.	2013/12/12	An autoimmune disease-associated gene, Lnk/SH2B3 controls production and functions of DC subsets and regulates inflammatory T cell differentiation. （Poster notice，General）
46.	2013/12/11	Lnk/Sh2b3 adaptor protein prevents the accumulation of inflammatory CD8+ T cells and intestinal villous atrophy. （Speech，General）
47.	2013/08/23	Lnk/Sh2b3, and intracellular adaptor associated with celiac disease and autoimmune diabetes, regulates accumulation of inflammatory T cells and prevents intestinal villous atrophy. （Poster notice，General）
48.	2012/12/07	An autoimmune disease-associated gene, Lnk/SH2B3 controls signaling of inflammatory cytokines in dendritic cells and regulates T cell differentiation （Speech，General）
49.	2012/12/07	IgE production is under the control of the Sh2b adaptor protein family, Aps/Sh2b2 and Lnk/Sh2b3 in B cells （Speech，General）
50.	2011/11/28	An autoimmune disease-associated gene, Lnk/SH2B3 controls signaling of inflammatory cytokines in dendritic cells and regulates regulatory T and helper T cell development （Speech，General）
51.	2011/11/28	CD8⁺ T cells cause inflammation and atrophy of intestinal villi in the absence of Lnk/Sh2b3, a shared risk factor gene associated with type-1 diabetes and celiac disease （Speech，General）
52.	2011/11/27	IgE-specific impairment in humoral immune responses by the absence of Aps/Sh2b2, a member of Lnk/Sh2b adaptor family （Speech，General）
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■ Belonging society

1.	1998/05～	The Japanese Society for Immunology (JSI)
2.	2001/12～	The Molecular Biology Society of Japan (MBSJ)
3.	2016/11～	Japan College of Rheumatology