Faculty Information - Akira Hanashima

（Last updated : 2025-04-02 17:22:29）

Akira Hanashima
Department Kawasaki Medical School Kawasaki Medical School, Department of Physiology 1,

Position Assistant Professor

■ Present specialized field

Biomedical engineering, Animal physiological chemistry, physiology and behavioral biology, Evolutionary biology, Biogeosciences, Physiology

■ Journal

1.	2024/06/14	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.
2.	2024/04/21	Comparative analysis of ventricular stiffness across species.
3.	2024/03/11	Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
4.	2022/11/04	Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon
5.	2022/08/20	Oxygen environment and cardiac regeneration
6.	2022/05/20	Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
7.	2019/10	Transcripts of the nebulin gene from Ciona heart and their implications for the evolution of nebulin family genes.
8.	2019/04	A great legacy of muscle research and education from Dr. Sumiko Kimura
9.	2018/12	Obituary: Sumiko Kimura 1947-2018
10.	2018/05	Turtle spongious ventricles exhibit more compliant diastolic property and possess larger elastic regions of connectin in comparison to rat compact left ventricles
11.	2017/06	Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.
12.	2017/01	Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle
13.	2015/12	Left ventricular mechanics and myocardial calcium dynamics in short-term and long-term hyperthyroid mice
14.	2014	Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1.
15.	2014	Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors.
16.	2013	Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.
17.	2012	Actin capping proteins, CapZ (beta-actinin) and tropomodulin in amphioxus striated muscle.
18.	2012	Genomic- and protein-based approaches for connectin(titin) identification in the ascidian Ciona intestinalis.
19.	2011	Amphioxus Connectin Exhibits Merged Structure as Invertebrate Connectin in I-Band Region and Vertebrate Connectin in A-Band Region.
20.	2010	Isolation of Nebulin from Rabbit Skeletal Muscle and Its Interaction with Actin.
21.	2009	Characterization of amphioxus nebulin and its similarity to human nebulin.
22.	2009	Structure of the amphioxus nebulin gene and evolution of the nebulin family genes.
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■ Presentation

1.	2025/03/19	Evolutionary and physiological analysis of molluscan hearts based on the muscle elastic protein connectin （口頭，一般）
2.	2022/09/10	Evolution of an unique blood pump system in the jawless lamprey （口頭，一般）
3.	2022/03/18	Elucidation of mammalian heart evolution by multiscale analysis of the lobster heart （ポスター掲示，一般）
4.	2019/03/30	Comparison of cardiomyocyte kinetics of rat left ventricle and turtle ventricle （ポスター掲示，一般）
5.	2019/03/30	Evolutional relationship between hearts and elastic protein connectins （ポスター掲示，一般）
6.	2019/03/29	Nuclear connectin novex-3 is essential for proliferation of hypoxic fetal cardiomyocytes （ポスター掲示，一般）
7.	2018/06/19	Comparative study of tensile properties of ventricular cardiomyocytes of rat and turtle （ポスター掲示，一般）
8.	2018/03/30	Comparison of extensibility of rat compact left ventricle and turtle spongious ventricle （ポスター掲示，一般）
9.	2018/03/29	Elastic structures of connectin shortened in coronary circulation hearts （ポスター掲示，一般）
10.	2016/11/17	Relationship between heart evolution and elastic structure of connectin in vertebrate （ポスター掲示，一般）
11.	2016/04/28	Elastic structure of connectin in the hearts with coronary and non-coronary circulation （ポスター掲示，一般）
12.	2016/04/27	Fam64a is essential for low oxygen-induced fetal cardiomyocyte proliferation （ポスター掲示，一般）
13.	2016/03/22	Elastic structures of cardiac connectin in the vertebrate hearts with coronary and sinusoidal circulation （ポスター掲示，一般）
14.	2016/03/22	Identification of critical molecule mediating oxygen-dependent cell cycle arrest of cardiomyocytes around birth in mice （ポスター掲示，一般）
15.	2015/02	Proteins in striated muscles that transcribed from the contiguous region of connectin gene. （ポスター掲示，一般）
16.	2014/07	The analysis of novel proteins in striated muscle that are transcribed from connectin upstream genes. （ポスター掲示，一般）
17.	2014/02	Localization and binding partners of SESTD1 in skeletal muscles. （ポスター掲示，一般）
18.	2012/04	Genomic- and Protein-Based Approaches for Connectin-Like Protein Identification in Amphioxus and Ascidian. （口頭，特別講演・招待講演など）
19.	2010/09	Amphioxus striated muscle has beta-actinin and tropomodulin. （ポスター掲示，一般）
20.	2010/09	The connectin-like protein gene of amphioxus striated muscle. （ポスター掲示，一般）
21.	2009/08	Sequence of the connectin-like giant proteins in invertebrate muscle. （ポスター掲示，一般）
22.	2009/07	C-terminus of nebulin binds to alpha-actinin. （ポスター掲示，一般）
23.	2008/06	Sequence of the C-terminal region of amphioxus nebulin and its binding proteins. （ポスター掲示，一般）
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