Faculty Information - Tomoyuki Mukai

（Last updated : 2026-05-27 18:42:32）

Tomoyuki Mukai
Department Kawasaki Medical School Kawasaki Medical School, Department of Immunology and Molecular Genetics,

Position Professor

■ Current specialization

Immunology, Connective tissue disease and allergy, Pathological biochemistry, Molecular biology, Genetics

■ Journal Articles

1.	2026/02/28	Aerobic Exercise Attenuates Epidermal Hyperplasia in an Obesity-Associated Psoriasiform Dermatitis Model
2.	2025/10	Biologics and Small-Molecule Therapies in Netherton Syndrome: A Comprehensive Review
3.	2025/04/05	Consideration of useful patient-reported outcome measures to identify unmet medical needs of children and adults with autoimmune and autoinflammatory diseases
4.	2025/01/29	Epstein-Barr virus induced 3 attributes to TLR7-mediated splenomegaly
5.	2023/10/10	"Input/output cytokines" in epidermal keratinocytes and the involvement in inflammatory skin diseases
6.	2023/08/14	Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model
7.	2023/01/23	Editorial: A new frontier in translational research on autoinflammatory diseases - various aspects of innate immunity on human diseases
8.	2022/12/02	Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan
9.	2022/08	Iliopectineal bursitis
10.	2022/07/22	TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1
11.	2022/05/14	IL-17A promotes vascular calcification in an ex vivo murine aorta culture
12.	2022/04/13	Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation
13.	2022/03/10	IL-17A promotes vascular calcification in an ex vivo murine aorta culture
14.	2022/02	Osteopoikilosis
15.	2021/11/27	Iliopectineal bursitis
16.	2021/11/07	Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model
17.	2021/09	Barium‐induced pneumatosis intestinalis in a patient with anti‐synthetase syndrome
18.	2021/08/31	The "Ant-farm"-like Appearance of Restricted Lower Limb Vasculitis on Fluorodeoxyglucose-positron Emission Tomography: A Case Series
19.	2021/08/24	Dagger Sign in Ankylosing Spondylitis
20.	2021/06/23	Purple urine bags reflecting an aging society
21.	2021/06/18	A tiger man: a case of muscular sarcoidosis
22.	2021/05/14	Osteopoikilosis
23.	2021/04/17	SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.
24.	2021/03	In vivo analysis of thrombus formation in arthritic mice.
25.	2021/03	Severe oral stomatitis due to reactivation of herpes simplex virus type 1 in a methotrexate-treated patient with dermatomyositis.
26.	2021/01/26	Deletion of Mir223 exacerbates lupus nephritis by targeting S1pr1 in Faslpr/lpr mice
27.	2021/01	Certolizumab pegol-induced immunoglobulin A vasculitis in a patient with rheumatoid arthritis
28.	2021/01	Tattoo skin reaction as a skin manifestation of systemic sarcoidosis
29.	2020/10/30	Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice
30.	2020/07/10	Tsukamurella pulmonis central venous catheter infection mimicking proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA)-associated vasculitis.
31.	2020/06/10	Effect of Angiotensin II on Bone Erosion and Systemic Bone Loss in Mice with Tumor Necrosis Factor-Mediated Arthritis
32.	2020/02	Paraneoplastic Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Should be Treated with Low-dose Prednisolone During Pembrolizumab Therapy
33.	2020/01	Aortitis which developed after the administration of granulocyte-colony stimulating factor.
34.	2019/08	Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor-associated periodic syndrome
35.	2019/05	Infection of Helicobacter cinaedi Should be Treated for an Adequate Duration with Combined Antibiotic Therapy: Author's Reply.
36.	2019/04	Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Fas^lpr Mice.
37.	2019/02/22	Tankyrase (PARP5) Inhibition Induces Bone Loss through Accumulation of Its Substrate SH3BP2.
38.	2019/01	Complete resolution of giant cell arteritis after tocilizumab monotherapy determined by positron emission tomography-CT
39.	2018/12	Bacteremia possibly caused by Helicobacter cinaedi and associated with painful erythema in rheumatoid arthritis with malignant lymphoma
40.	2018/10	Bladder carcinoma in situ in a patient with lupus cystitis
41.	2018/06	Scrub typhus (Tsutsugamushi disease) in a patient presenting with hemophagocytic syndrome
42.	2018/03	IgG4-related autoimmune pancreatitis complicated by splenic artery pseudoaneurysm.
43.	2018/03	Treatment of refractory rheumatoid pleural effusion with abatacept.
44.	2018/01	Cherubism mice also deficient in c-Fos exhibit inflammatory bone destruction executed by macrophages that express MMP14 despite the absence of TRAP+ osteoclasts.
45.	2018/01	Chronic reactive arthritis associated with prostatitis caused by Neisseria meningitidis.
46.	2018/01	Mycophenolate mofetil treatment in a patient with recurrent lymphocytic hypophysitis.
47.	2018/01	Necrosis of the gastrocnemius muscle in microscopic polyangiitis.
48.	2018/01	Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis.
49.	2017/12	Nivolumab-induced polyarthritis
50.	2017/09	Successful treatment using rituximab in a patient with refractory polymyositis complicated by scleroderma renal crisis
51.	2017/08	POEMS syndrome in a patient with rheumatoid arthritis
52.	2015/12	Arthritis in a patient with Takayasu arteritis
53.	2015/03	Loss of SH3 Domain-Binding Protein2 Function suppresses Bone Destruction in Tumor Necrosis Factor-Driven and Collagen-Induced Arthritis in Mice
54.	2015/02	Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice.
55.	2014/09	Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism.
56.	2014/08	SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model
57.	2014/04	Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-a-induced inflammation and bone loss.
58.	2011/07	Long-term remission of ocular and extraocular manifestations in Behcet's disease using infliximab.
59.	2011/06	[Efficacy and safety of combination therapy with mizoribine and methotrexate for rheumatoid arthritis resistant with methotrexate]. Japanese.
60.	2010/12	Effect of infliximab on tumor necrosis factor-alpha-induced alterations in retinal microvascular endothelial cells and retinal pigment epithelial cells.
61.	2010/08	Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-alpha in C2C12 cells.
62.	2010/06	Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling.
63.	2010/01	Infliximab treatment of severe genital ulcers associated with Behcet disease.
64.	2009/07	Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells.
65.	2008/03	Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway
66.	2007	Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation
67.	2006/10	Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly.
68.	2006	Manifestation of rheumatoid arthritis after transsphenoidal surgery in a patient with acromegaly
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■ Presentations

1.	2025/12/12	Functional analysis of UBA1 mutations responsible for VEXAS syndrome （Poster notice，General）
2.	2025/12/10	The cytokine component Epstein-Barr virus-induced 3 (EBI3) is involved in splenomegaly induced by TLR7 stimulation （Poster notice，General）
3.	2025/09/01	Somatic UBA1 mutations, the gene responsible for VEXAS syndrome, elicit inflammatory response by enhancing cell death （Poster notice，General）
4.	2025/04/26	Exploring the Role of EBI3 and IL-27 in Imiquimod-induced Splenomegaly （Poster notice，General）
5.	2024/09/04	Therapeutic Effects of GLP-1 Agonist on Psoriasis in Obese Mice （Poster notice，General）
6.	2023/12/08	Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis in a murine model （Poster notice，General）
7.	2023/12/07	Epstein-Barr virus induced 3 (EBI3), a component of heterodimer cytokine, promotes TLR7-induced inflammatory disease. （Poster notice，General）
8.	2023/05/10	Accompanying non-alcoholic steatohepatitis exacerbates psoriasis in a murine model （Poster notice，General）
9.	2022/04/27	Obesity and hyperlipidemia synergistically exacerbate psoriatic skin inflammation （General）
10.	2022/04/25	Deletion of Mir223 exacerbates lupus nephritis by targeting S1pr1 in Faslpr/lpr mice （Speech，General）
11.	2021/12/08	The investigation of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models （Poster notice，General）
12.	2021/11/12	Deletion of Mir223 exacerbates lupus nephritis by targeting S1pr1 in Faslpr/lpr mice （Poster notice，General）
13.	2021/08/28	The study of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models （Speech，General）
14.	2021/04/26	Excessive Angiotensin II exacerbates bone erosion in a murine tumor necrosis factor-mediated arthritis model （Speech）
15.	2020/12/04	The role of an adaptor protein SH3BP2 in the pathogenesis of systemic lupus erythematosus （Poster notice，General）
16.	2020/12/02	Deletion of Mir223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Fas lpr/lpr Mice （Poster notice，General）
17.	2020/11/07	SH3BP2 Deciency Ameliorates Murine Systemic Lupus Erythematosus （Poster notice，General）
18.	2020/11/05	Deletion of miR-223 exacerbates lupus nephritis by targeting S1pr1 in Faslpr/lpr mice （Poster notice，General）
19.	2020/10/24	Deletion of miR-223 exacerbates lupus nephritis by targeting S1pr1 in Faslpr/lpr mice （Poster notice，General）
20.	2020/10/24	Effect of Angiotensin II on Bone Erosion and Systemic Bone Loss in Mice with Tumor Necrosis Factor-Mediated Arthritis （Poster notice，General）
21.	2020/10/24	SH3BP2 deficiency ameliorates murine systemic lupus erythematosus （Poster notice，General）
22.	2020/07/08	全身性エリテマトーデスモデルマウスにおけるアダプター蛋白SH3BP2 の自己免疫現象における役割の解明（Poster notice，General）
23.	2020/02/16	Successful treatment using subcutaneous tocilizumab in a patient with Schnitzler syndrome （Speech，General）
24.	2019/11/10	The role of adopter protein SH3BP2 in a murine systemic lupus erythematosus model （Poster notice，General）
25.	2019/11/10	The Study of the Novel G87V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS) （Poster notice，General）
26.	2019/05/14	Inhibition of Interleukin-6 Signaling on Aortitis in Interleukin-1 Receptor Antagonist Deficient Mice （Poster notice，General）
27.	2019/04/17	SH3BP2 gain-of-function mutation ameliorates lupus in B6.MRL-Faslpr mice （Speech，General）
28.	2019/04/16	The Study of the novel G58V mutation in the TNFRSF1A gene identified in a family with TNF Receptor-Associated Periodic Syndrome(TRAPS) （Speech，General）
29.	2019/04/15	In vivo imaging of arterial thrombus formation in a murine arthritis model （Speech，General）
30.	2018/10/21	The novel G58V mutation in the TNFRSF1A gene identified in a family with TNF Receptor-Associated Periodic Syndrome (TRAPS) decreases the cell surface expression of TNFR1 （Poster notice，General）
31.	2018/04/27	Bone systemic administration of angiotensin II and its type 1 receptor gene deletion exacerbates erosive bone destruction in hTNF-transgenic arthritis mice （Speech，General）
32.	2018/04/27	Myostatin inhibition reduces bone loss in an unloading osteoporosis model （Speech，General）
33.	2018/04/27	Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastgenesis （Speech，General）
34.	2018/04/27	SH3BP2 gain-of-function mutation alleviates lupus phenotypes in B6.MRL-Faslpr mice （Speech，General）
35.	2018/04/26	Functional analysis of the novel G58V mutation in the TNFRSF1A gene identified in a family with TNF receptor-associated periodic syndrome(TRAPS) （Speech，General）
36.	2017/11/07	SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice （Poster notice，General）
37.	2017/11/06	Angiotensin II Type I Receptor Deficiency Exacerbates Erosive Bone Destruction ofhTNF-Transgenic Arthritis Mice （Poster notice，General）
38.	2017/11/05	Functional Analysis of the Novel G58V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS) （Poster notice，General）
39.	2017/11/05	Tankyrase/Wnt Inhibitor Upregulates Osteoclastogenesis and Osteoblastogenesis Via SH3BP2 （Poster notice，General）
40.	2017/11/05	The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models （Poster notice，General）
41.	2017/04/21	Tankyrase regulates bone mass and osteoclastogenesis （Speech，General）
42.	2017/04/20	Angiotensin II exacerbates bone destruction in human TNF-transgenic arthritis mice （Speech，General）
43.	2017/04/20	The effect of myostatin inhibition on bone loss in murine osteoporosis models （Poster notice，General）
44.	2016/11/14	Tankyrase Regulates Osteoclastogenesis Via SH3BP2 （Poster notice，General）
45.	2016/11/13	Angiotensin II Exacerbates Bone Destruction in TNF-Transgenic Arthritis Mice （Poster notice，General）
46.	2016/04/23	Tankyrase Inhibitor Promotes Osteoclastogenesis by Enhancing SH3BP2 expression （Speech，General）
47.	2015/11/16	Tankyrase regulates osteoclastogenesis via SH3BP2 expression （Poster notice，General）
48.	2014/09/14	Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism （Poster notice，General）
49.	2014/08/01	SH3BP2 regulates TNF-a-induced osteoclastogenesis via NFATc1 and TNF-a-mediated inflammatory bone loss （Speech，General）
50.	2014/04/17	SH3BP2''Cherubism'' Gain-of-Function Mutation Exacerbates Inflammation and Bone Erosion in Murine Collagen-Induced Arthritis Model （Speech）
51.	2014/03/22	Cherubism Mutation in SH3BP2 Enhances TNF-induced Osteoclast Differentiation and Function （Poster notice，General）
52.	2014/03/22	SH3BP2 Regulates Inflammation and Bone Destruction in Collagen-Induced Arthritis Model （Speech）
53.	2013/10/04	Etanercept administration to Neonatal SH3BP2 Knock-In Cherubism Mice Prevents TNF-a-induced inflammation and Bone Loss
54.	2013/10/04	SH3BP2 "Cherubism" Gain-of-Function Mutation Exacerbates Inflammation and Bone Erosion in Murine Collagen-Induced Arthritis Model （Speech）
55.	2013/04	Cherubism Mutation in SH3BP2 Enhances TNF-induced Osteoclast Differentiation and Function
56.	2013/03/22	SH3BP2 Cherubism Mutation Enhances TNF-induced Osteoclastogenesis
57.	2013/03/21	Mechanism of Inflammation in the Mouse Model of Cherubism
58.	2012/10/12	Bone Marrow Transplantation Reduces Inflammation and Inflammation-Induced Bone Loss in Cherubism Mice
59.	2012/10/12	The SH3BP2 Cherubism Mutation Promotes TNF induction of Osteoclastogenesis independent of RANKL
60.	2012/04/19	SH3BP2 Cherubism Mutation Enhances Lipopolysaccharide-induced Osteoclastogenesis
61.	2011/11	SH3BP2 "Cherubism" Gain-of-Function Mutation Exacerbates Inflammation and Bone Erosion in Collagen Induced Arthritis
62.	2011/09	Etanercept for the treatment of Inflammation in Cherubism Mice
63.	2011/09	SH3BP2 Cherubism Mutation Enhances Lipopolysaccharide-induced Osteoclastogenesis
64.	2011/03/19	Mechanisms of inflammation in Cherubism
65.	2010/10	Mechanism of Inflammation in Cherubism
66.	2008/10	Effects of TNFa, IL-1, and IL-17 on osteoblast differentiation of human bone marrow-derived mesenchymal stem cells
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