Faculty Information - Takenobu Yamamoto

Publications

Journal Articles

Presentations

Professional Organizations

Awards

（Last updated : 2026-08-24 17:42:33）

Takenobu Yamamoto
Department Kawasaki Medical School Kawasaki Medical School, Department of Dermatology,

Position Associate Professor

■ Publications

2012/12

extranodal NK/T-cell lymphoma, nasal type

■ Journal Articles

1.	2026/06/01	Sunflower Seed–Induced Anaphylaxis with IgE Reactivity to 2S Albumin and novel 60kDa antigen Identified by Immunoblot Analysis.
2.	2025/11/01	Panton-Valentine leukocidin-producing community-acquired methicillin-resistant Staphylococcus aureus in skin and soft tissue infections: Clinical and epidemiological insights from Japan.
3.	2025/06/01	Differences in the management of toxic epidermal necrolysis related and unrelated to immune checkpoint inhibitors
4.	2025/05/29	Comparing immunopathogenesis of non-human immunodeficiency virus immune reconstitution inflammatory syndrome and immune-related adverse events: A prospective multicenter cohort study.
5.	2025/03	Monokine induced by gamma interferon as a marker of systemic hydroa vaccniforme lymphoproliferative disorder
6.	2024/11	Immune reconstitution is the trigger of herpes zoster with lymphopenia and high neutrophil-to-lymphocyte ratio (NLR) in a retrospective cohort study
7.	2024/11	Simultaneous distinct subcutaneous fungal infections with chromoblastomycosis due to Exophiala xenobiotica and hyalohyphomycosis due to Scedosporium apiospermum in a patient with severe cellular immunodeficiency
8.	2024/10	An Exploratory Study of the Efficacy and Safety of Amenamevir for the Treatment of Herpes Zoster in Patients Receiving Immunosuppressive Drugs
9.	2024/03/22	Sweat protects against contact hypersensitivity: Transient sweat suppression compromises skin barrier function in mice
10.	2024/02/01	Efficacy and safety of intravenous fosphenytoin for patients with acute herpes zoster-associated pain: A placebo-controlled randomized trial
11.	2023/09/11	Biomarkers for predicting immune reconstitution inflammatory syndrome in dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: A retrospective observational study with a case series
12.	2023/05/14	Positron emission tomography and computed tomography imaging in primary cutaneous nocardiosis with osteomyelitis clinically mimicking soft tissue sarcoma
13.	2023/04/17	Dramatic deterioration or new-onset dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid after COVID-19 vaccination: A possible manifestation of immune reconstitution inflammatory syndrome
14.	2023/02/01	Risk factor-specific mortality in herpes zoster in a retrospective cohort study: The neutrophil-to-lymphocyte ratio is a useful biomarker for predicting late-onset complications resulting in death.
15.	2022/09/01	Herpes simplex virus-induced murine dry skin model through sweating disturbance.
16.	2022/07	Clinical features of dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid in Japan: A nationwide retrospective observational study.
17.	2022/06	Anti-Cytomegalovirus Therapy: Whether and When to Initiate, Those Are the Questions
18.	2022/06	Neutrophil to lymphocyte ratio is predictive of severe complications and mortality in patients with dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid: A retrospective longitudinal observational study
19.	2022/03/31	Herpes zoster in lung cancer patients treated with PD-1/PD-L1 inhibitors
20.	2021/10/01	Role of proinflammatory cytokines in the pathophysiology of herpes simplex virus superinfection in Darier disease
21.	2021/03	Severe oral stomatitis due to reactivation of herpes simplex virus type 1 in a methotrexate-treated patient with dermatomyositis.
22.	2021/02	Varicella Zoster Virus-Associated Meningitis as a Rebound Varicella Zoster Disease after Antiviral Discontinuation
23.	2020/09/30	Hypercalcemia Associated with Extramammary Paget's Disease
24.	2020/09/17	Detection of multinucleated giant cells in differentiated keratinocytes with herpes simplex virus and varicella zoster virus infections by modified Tzanck smear method
25.	2020/08/15	Folliculotropic mycosis fungoides treated with electron beam therapy that evolved into fatal, tumor-stage mycosis fungoides and erythroderma with multiple ulcerations
26.	2020/05/01	A Case of Generalized Ringworm Associated iuth Hypercortisolemia
27.	2020/04/07	The aim of the measurement of Epstein-Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites
28.	2020/03	A case of neonatal lupus erythematosus with fever in an infant born from an anti-SSA/Ro and anti-SSB/Lo antibody-positive mother
29.	2019/07/15	Japanese Spotted Fever: A Rare Cause of Arthritis
30.	2019/02	Hydroa vacciniforme: a distinctive form of Epstein-Barr virus-associated T-cell lymphoproliferative disorders.
31.	2019/01	Cell-to-cell transmission of HSV-1 in differentiated keratinocytes promotes multinucleated giant cell formation.
32.	2018/07	Benign cephalic histiocytosis: A case with some infiltrate of CD1a positive langerin negative cells
33.	2018/02	High calcium enhances the expression of double-stranded RNA sensors and antiviral activity in epidermal keratinocytes.
34.	2017/01	A case of sitosterolemia due to compound heterozygous mutations in ABCG5: clinical features and treatment outcomes obtained with colestimide and ezetimibe
35.	2016/12	Differential diagnosis of herpetiform vesicles by a non-invasive, molecular method using crusts or blister roofs: Sensitivity, specificity and likelihood ratio
36.	2016/08	Numerous intertriginous xanthomas in infant: A diagnostic clue for sitosterolemia
37.	2016/06	A case of glaucoma in severe atopic dermatitis
38.	2016/06	Epstein-Barr virus reactivation is induced, but abortive, in cutaneous lesions of systemic hydroa vacciniforme and hypersensitivity to mosquito bites
39.	2016/03	Blistering disease associated with diffuse large B-cell lymphoma but without autoantibodies.
40.	2015/08	Interferon-gamma enhances TLR3 expression and anti-viral activity in keratinocytes.
41.	2015/01	Survival Rates and Prognostic Factors of Epstein-Barr Virus-Associated Hydroa Vacciniforme and Hypersensitivity to Mosquito Bites.
42.	2014/12	Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis
43.	2014/09	Cathelicidin antimicrobial peptide LL-37 augments IFN-b expression and anti-viral activity induced by double-stranded RNA in keratinocytes.
44.	2014/01	Activation of H2AX and ATM in varicella-zoster virus (VZV)-infected cells is associated with expression of specific VZV genes
45.	2013/03	Poikilodermatous mycosis fungoides with a CD8+ CD56+ immunophenotype: a case report and literature review.
46.	2012/10	Diversity of Epstein-Barr virus BamHI-A rightward transcripts and their expression patterns in the lytic and latent infections.
47.	2012/05	Hydroa vacciniforme is pathogenically associated with circulating Epstein-Barr virus-infected γδ T-cells
48.	2012/05	Oculomucosal and gastrointestinal involvement in Epstein-Barr virus-associated hydroa vacciniforme.
49.	2012/05	Valproic acid inhibits proliferation of EB virus-infected natural killer cells.
50.	2012/04	グラム染色・Tzanck試験　-コツと落とし穴-
51.	2012/04	種痘様水疱症の1例
52.	2012/02	Proteomic study identified HSP 70kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms.
53.	2012/01	Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic active Epstein-Barr virus disease of γδ T cells.
54.	2011/09	Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions
55.	2010/10	Production of proinflammatory cytokines without invocation of cytotoxic effects by an Epstein-Barr virus-infected natural killer cell line established from a patient with hypersensitivity to mosquito bites.
56.	2010/09	A prospective analysis of anti-desmoglein antibody profiles in patients with rheumatoid arthritis treated with thiol compounds Original Research Article.
57.	2009/07	Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas.
58.	2008/09	Tracing of the molecular remnants of herpes virus infections in necrotic skin tissue
59.	2007/02	A Novel, Noninvasive Diagnostic Probe for Hydroa Vacciniforme and Related Disorders: Detection of Latency-Associated EB Virus Transcripts in the Crusts
60.	2006/05	Pathogenic Link Between Hydroa Vacciniforme and Epstein-Barr Virus-Associated Hematologic Disorders
61.	2005/05	Characterization of Epstein-Barr virus-infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites
62.	2005/04	Eradication of epstein-barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1
63.	2004/04	A Spectrum of Clinical Manifestations Caused by Host Immune Responses against Epstein-Barr Virus Infections
64.	2002/08	Erythrodermic actinic reticuloid is characterized by the overspill of oligoclonal CD8+ lymphocytes responsive to ultraviolet irradiation.
65.	2002/08	Photosensitivity in hydroa vacciniforme is a photo-Koebner phenomenon induced by infiltration of Epstein-Barr virus-infected NK/T cells.
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■ Presentations

1.	2026/04/09	Acantholysis functions as an ‘epidermal separation barrier’, preventing the spread of Herpes simplex virus infection within the epidermis （Poster notice，General）
2.	2026/04/09	Detection of Rickettsia japonica DNA in blood is one of risk factors for severe Japanese spotted fever （Poster notice，General）
3.	2026/03/20	Cutaneous chronic active Epstein-Barr virus: hydroa vacciniforme and severe mosquito bite allergy （Speech，Panelist at Symposium/Workshop (Applied)）
4.	2025/12/07	The mysterious relationship between herpes and pemphigus: Acantholysis inhibits the spread of HSV infection within the epidermis （Speech，General）
5.	2025/05/10	Sweat suppression promotes a Th2-biased sensitization to food allergens and anaphylaxis in an IL-6-dependent manner （Speech，General）
6.	2025/03/28	Clinical and epidemiological characteristics of Panton-Valentine leucocidin-producing methicillin-resistant Staphylococcus aureus infections, especially USA300 strains in Japan （Poster notice，General）
7.	2023/07/03	The neutrophil-to-lymphocyte ratio is a useful biomarker for predicting delayed death in herpes zoster （Poster notice，General）
8.	2023/05/14	Disturbed epithelial integrity protects against cell-to-cell transmission of HSV-1 in keratinocytes （Poster notice，General）
9.	2023/05/11	Disturbed epithelial integrity protects against cell-to-cell transmission of HSV-1 in keratinocytes （Poster notice，General）
10.	2023/05/11	Local injection with anti-herpes simplex virus antibodies protects against development of herpes simplex virus–induced sweating disturbance （Poster notice，General）
11.	2023/05/11	The predictive and diagnostic biomarkers of immune-related adverse events vary by the affected organ （Poster notice，General）
12.	2022/12/02	Cytokine profiles for predicting the development of COVID-19 vaccine-associated bullous pemphigoid （Speech，General）
13.	2022/12/02	Herpes simplex virus-induced urine dry skin model through sweating disturbance （Speech，General）
14.	2021/12/03	Lymphocyte count and neutrophil-to-lymphocyte ratio at the onset of herpes zoster are useful biomarker for predicting life prognosis （Speech，General）
15.	2021/12/03	Occurrence of immune reconstitution inflammatory syndrome can be predicted by cytokine profiles in dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid （Speech，General）
16.	2020/12/11	Mouse models of sweating disturbance associated with dry skin induced by cutaneous inoculation of herpes simplex virus （Poster notice，General）
17.	2020/12/11	Neutrophil-to-lymphocyte ratio as a useful biomarker can predict outcomes in dipeptidyl peptidase-4 inhibitor associated bullous pemphigoid （Poster notice，General）
18.	2020/12/11	The association between the severity of hydroa vacciniforme and Monokine induced by gamma interferon （Poster notice，General）
19.	2019/11/08	Multinucleated giant cell or acantholytic cell with herpes virus infections is determined under differentiated condition of keratinocyte. （Poster notice，General）
20.	2018/10/04	Dynamic cellular change in cultured keratinocytes caused by herpes simplex virus-1 infection under the different calcium concentration （Speech，General）
21.	2017/12/15	HSV1 related giant cell formation depends on keratinocyte differentiation. （Speech，General）
22.	2016/12/11	Markedly elevated EBV DNA load in plasma predicts the occurrence of HPS in hydroa vacciniforme and hypersensitivity to mosquito bites. （Speech，General）
23.	2016/12/09	Herpes simplex virus type 1 entry and replication in the keratinocytes depends on extracellular calcium concentration. （Speech，General）
24.	2016/10/13	Cases of Japanese spotted fever and scrub typhus (Tsutsugamushi disease) experienced in our hospitals （Poster notice，General）
25.	2016/10/13	Numerous intertriginous xanthomas in infant: a diagnostic clue for sitosterolemia. （Speech，General）
26.	2016/09/07	Lymphocyte subsets and reactivation markers related to severe phenotypes of cutaneous EBV-associated T/NK lymphoproliferative disorders （Speech，General）
27.	2015/12/11	Distinct lymphocyte subsets responsible for classical and systemic hydroa vacciniforme （Speech，General）
28.	2014/12/12	Effects of innate immunity and cytokines on HSV infection in Darier's disease （Poster notice，General）
29.	2014/12/12	Peripheral immunological tolerance in molluscum contagiosum and induction of p53-dependent apoptosis （Poster notice，General）
30.	2014/06/11	A case of disseminated HSV-1 infection initiated by eczema herpeticum in a patient with Darier's disease （Speech，General）
31.	2013/05/08	Eradication of cutaneous herpesvirus infections by nucleic acid sensors and cytotoxic T lymphocyte-mediated apoptotic processes （Poster notice，General）
32.	2013/05/08	Pathogenic cell types, molecular mechanisms and prognostic factors in EB virus-associated cutaneous T/NK lymphoproliferative disorders （Poster notice，General）
33.	2013/02/16	Immediate-early (IE) gene reactivation signal, BZLF1, is a molecular marker for a poor prognosis of EBV-associated T/NK lymphoproliferative skin diseases （Speech，General）
34.	2012/12/08	A reactivation signal, BZLF1 expression, is a prognostic marker for severe hydroa vacciniforme and hypersensitivity to mosquito bites （Speech，General）
35.	2012/12/08	Ataxia telangiectasia patients cannot cause severe Herpes Simplex because of disturbed Herpes simplex virus replication by ATM mutation （Speech，General）
36.	2012/12/08	Pemphigus IgG treated keratinocytes are susceptible to herpes simplex virus induced cell dissociation, but protective to virus replication. （Speech，General）
37.	2012/12/07	Cathelicidin antimicrobial peptide LL-37 augments anti-viral activity induced by double-stranded RNA in keratinocytes. （Poster notice，General）
38.	2012/12/07	Interferon gamma enhances anti-viral activity induced by double-stranded RNA in keratinocytes. （Poster notice，General）
39.	2012/05/11	Clues for Epstein-Barr virus reactivation with the subsequent outbreak of immune responses in skin lesions of hypersensitivity to mosquito bites. （Poster notice，General）
40.	2011/12/03	Analyses of early events in primary VZV infection: New culture system to analyze primary VZV infection in human tonsil ex vivo （Poster notice，General）
41.	2011/12/03	Comparative proteomic analysis identified HSPA1A as a candidate target for enhancing apoptosis induced by histone deacetulase inhibitor （Speech，General）
42.	2011/12/03	Hydroa vcciniforme is pathogenically associated with circulating Epstein-Barr virus-infected gamma-delta T-cells （Speech，General）
43.	2011/09/10	PROTEOMIC ANALYSIS OF HISTONE DEACETYLASE INHIBITOR SENSITIVITY IN LYMPHOID MALIGNANCIES （Poster notice，General）
44.	2010/12/04	ATM activation is indispensable in HSV, but ATM/ATR activation is not necessary in VZV for efficient replication （Speech，General）
45.	2010/12/04	ATM activation is indispensable in HSV, but ATM/ATR activation is not necessary in VZV for efficient replication （Speech，General）
46.	2010/12/04	Distinct infiltrating cell types of the lesional skin and the peripheral blood in EBV-associated T/NK lymphoproliferative disorders （Speech，General）
47.	2010/12/04	Establishment of acquired resistance to HDAC inhibitors （Speech，General）
48.	2010/12/04	Establishment of acquired resistance to HDAC inhibitors （Speech，General）
49.	2010/10	Severe hydroa vacciniforme with myocardial infiltration of EB virus-infected T-cells ~effective therapy with prednisolone and intermittent etoposide~ （Speech，General）
50.	2010/09	Severe hydroa vacciniforme with myocardial infiltration of EB virus-infected T-cells ~effective therapy with prednisolone and intermittent etoposide~ （Speech，General）
51.	2008/05/15	Cellular and molecular events leading to the immune escape phenomenon in molluscum contagiosum. （Poster notice，General）
52.	2008/05/15	Compensatory regulation of granulocyte colony-stimulating factor for hematopoietic stem cells results in neutrophilic dermatosis associated with myelodysplastic syndrome. （Poster notice，General）
53.	2008/05/15	Possibilities of valproic acid as antherapeutic tool for natural killer-cell neoplasms. （Poster notice，General）
54.	2008/05/15	Reactivation of Epstein-Barr virus is associated with severe cutaneous and systemic symptoms. （Speech，General）
55.	2008/05/15	Reduced Langerhans cell number in human papillomavirus (HPV)-related skin lesions is associated with low expression levels of macrophage inflammatory protein (MIP)-3alpha and E-cadherin. （Poster notice，General）
56.	2008/05/13	EBV gene expression and host immune system （Speech，Panelist at Symposium/Workshop (Appointed)）
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■ Professional Organizations

1.	1999/04～	Japan Dermatological Association
2.	1999/04～	Japan Organization of Clinical Dermatologists
3.	2001/04～	The Japanese Society for Investigative Dermatology
4.	2002/09～	The Japanese Society for Virology

■ Awards

1.	2008/08	The 12th Japan Herpesvirus Infections Forum (JHIF) scholarship Awards
2.	2018/10	7th joint meeting of SSSR & SCUR Best Oral Presentation Award