Faculty Information - Yoshio Naomoto

（Last updated : 2026-08-18 14:01:41）

Yoshio Naomoto
Department Kawasaki Medical School Faculty of Medicine, Kawasaki Medical School,

Position

■ Journal Articles

1.	2018/10	Descending necrotizing mediastinitis in a healthy young adult.
2.	2018/06	Development of an integrated CRISPRi targeting Np63 for treatment of squamous cell carcinoma.
3.	2017/11	Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma.
4.	2017/06	Decreased risk of esophageal cancer owing to cigarette and alcohol cessation in smokiers and drinkers:a systematic review and meta-analisis
5.	2017/04	False-Positive Cases of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomographic Scans in Metastasis of Esophageal Cancer
6.	2017/03	Gene signature driving invasive mucinous adenocarcinoma of the lung.
7.	2017/02	A Case of Cholesterol Crystal Embolization with Hemorrhagic Imntestinal Ulcer
8.	2017/02	A case of gastrointestinal stromal tumor (GIST) with peritoneal dissemination - Imatinib re-challenged case-
9.	2017/02	Evaluation of intra-ductal cancer spread using contrast superb micro-vascular imaging(SMI)-a case report-
10.	2016/10	A Case of Birt-Hogg-Dube (BHD) Syndrome Harboring a novel Folliculin (FLCN ) Gene mutation.
11.	2016/10	A long-living case of carotid aneurysm caused by inflammatory leiomyosarcoma.
12.	2016/06	Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma.
13.	2016/03	Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma.
14.	2016/02	Neo-adjuvant therapy or chemoradiotherapy can improve laryngeal preservation rates in patients with cervical esophageal cancer.A Japanese nationwide survey
15.	2016/02	SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma
16.	2015/10	A nation-wide survey of follow-up strategies for esophageal cancer patients after a urative esophagectomy or a complete response by definitive chemoradiotherapy in Japan
17.	2015/07	A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor.
18.	2015/06	Skin Tube Reconstruction for Esophageal Defects due to Postoperative Complications: Applying a skin flap in esophageal resection and reconstruction
19.	2015/06	TAE226,a Bis-Anilio Pyrimidine Compound,Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells
20.	2015/05	Feasibility of oral administration of S-1 as adjuvant chemotherapy in gastric cancer: 4-week S-1 administration followed by 2-week rest vs. 2-week administration followed by 1-week rest
21.	2015/05	Skin Tube Reconstruction for Esophageal Defects due to Postoperative Comlications:Applying a skin flap in esophageal resection and reconstruction
22.	2015/04	Non-occlusive mesenteric ischemia after splenic metastasectomy for small-cell lung cancer
23.	2015/01	Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society
24.	2014/12	A case report of isolated presacral squamous cell carcinoma developd four years after gastrectomy
25.	2014/12	Amino acid signaling in the intestine: The roles of glutamine, leucine and arginine
26.	2014/12	Disappearance of the spleen as a rare complication of infected pancreatic pseudocyst following acute relapsing phase of chronic pancreatitis
27.	2013/12	A Case of Acute Superior Mesenteric Artery Embolism with Severe Ischemic Liver Injury Successfully Treated by Endovascular Treatment.
28.	2013/11	Gastric function preserving esophagectomy for esophageal cancer
29.	2013/08	Inhibition of the Growth Factor MDK/Midkine by a Novel Small Molecule Compound to Treat Non-Small Cell Lung Cancers
30.	2013/01	Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.
31.	2013/01	Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer
32.	2012/12	A case of cecal volvulus in a cerebral palsy patient: Usefulness of multidetector computed tomography for preoperative diagnosis
33.	2012/12	Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.
34.	2012/11	Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma.
35.	2012/10	Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma.
36.	2012/09	Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer.
37.	2012/08	Jejunal interposition reconstruction with a stomach preserving esophagectomy improves postoperative weight loss and reflux symptoms for esophageal cancer patients.
38.	2012/07	Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity.
39.	2012/07	Giant gastrointestinal stromal tumor of the jejunum resected after treatmentwith imatinib
40.	2012/07	Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer.
41.	2012/04	Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.
42.	2010/12	Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer.
43.	2010/11	Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids.
44.	2010/10	Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc.
45.	2010/10	Portal/splenic vein thrombosis following splenectomy in gastric cancer surgery.
46.	2010/09	Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.
47.	2010/07	HSP90 and its inhibitors.
48.	2010/07	Responses to surgical stress after esophagectomy:Gene expression of heat shock protein 70,toll-like receptor 4,tumor necrosis factor- and inducible nitric oxide synthase.
49.	2010/04	Can it become a potential therapeutic target?
50.	2010/04	RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer.
51.	2010/03	Safer glycemic control using isomaltulose-based enteral formula: a pilot randomized crossover trial.
52.	2010/02	The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture.
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■ Presentations

1.	2018/09/28	Targeted silencing of SOX2 by an ATF showed antitumor effect in lung and esophageal squamous cell carcinoma （Poster notice）
2.	2018/09/16	Clinical significance of esophagogastroduodenoscopy in patients with esophageal motility disorders （Poster notice）
3.	2018/09/16	Esophageal squamous cell carcinoma is associated with chronic diseases as well as unhealthy lifestyles （Poster notice）
4.	2018/09/16	False positive cases of FDG-PET/CT in metastasis of esophageal squamous cell carcinoma （Poster notice）
5.	2018/06/11	Melanosis coli is not assosiated with associated with colonic cancer : a retrospective case-control study of 953 subjects （Speech，General）
6.	2018/06/08	A surgical case of jejunal aberrant pancreas containing high-grade pancreatic intraepithelial neoplasia(PanIN3) （Poster notice，General）
7.	2018/06/08	Remnant pancreatic resection for pancreatic cancer （Poster notice，General）
8.	2018/04/16	Targeted silencing of SOX2 by an artificial transcription factor showed antitumor effect in lung and esophageal squamous cell carcinoma （Poster notice，General）
9.	2017/10/16	TGFALPHA PROMOTES GROWTH OF LUNG TUMORS CARRYING EGFR MUTATION BUT NOT KRAS MUTATION IN TRANSGENIC MOUSE MODELS IN VIVO （Poster notice）
10.	2017/06/14	Laparocopic ventral hernia repair with fascial defect closure （Poster notice，General）
11.	2017/06/09	A surgical case of metachronous liver metastasis of hepatoid adenocarcinoma of the stomach （Poster notice，General）
12.	2017/06/08	Prognostic factors for resected adenocarcinomas of the ampulla of vater （Poster notice，General）
13.	2017/04/03	Development of a novel targeted therapy for malignant mesothelioma carcinoma by a midkine inhibitor. （Poster notice）
14.	2016/10/06	SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma （Speech，General）
15.	2016/06/15	Suturing Techniques for Closure of Fascial Defect during Laparoscopic Ventral Hernia Repairs:a review of the literature （Poster notice）
16.	2016/05/21	Negative association between esophageal squamous cell carcinoma and gastric mucosal atrophy in the current gastric mucosal condition in Japan
17.	2016/04/18	Sox2 silencing upregulates CDKNIA and suppresses growth of lung squamous cell carcinoma （Poster notice）
18.	2016/03/17	Minilaparoscopic inguinal hernia repair(m-TAPP)with 5mm laparoscope and 2mm grasper:An alternative to traditional TAPP （Poster notice）
19.	2015/04/21	Developmemt of a Sox2 targeting therapy for the treatment of lung squamous cell carcinoma （Poster notice，General）
20.	2015/04/20	Esphageal cancer exhibits a resistance to the chemical of IGF-1R with a maintained Ras-MAPK activity （Poster notice，General）
21.	2015/03/18	Remnant pancreatic resection for pancreatic cancer （Poster notice，General）
22.	2014/09/27	Sox2 silencing suppresses cell growth and colony formation of squamous cell lung cancer （Poster notice，Panelist at Symposium/Workshop (Applied)）
23.	2014/04/06	Effective use of MDK/Midkine and MEK inhibitor to treat KRas mutated pulmonary adenocarcinoma cells （Poster notice，General）
24.	2014/04/04	Inhibition of the growth factor midkine by a novel small molecule compound to treat pulmonary adenocarcinoma （Speech，General）
25.	2013/10/05	Inhibition of Midkine by a novel small molecule compound to treat non-small cell lung cancer （Speech，General）
26.	2013/06/19	LAPAROSCOPY ASSISTED PANCREATIC RESECTION FOR A GIANT SOLID PSEUDOPAPILLARY TUMOR: REPORT OF A CASE
27.	2013/06/19	THE USEFULNESS OF THE LEFT LATERAL DECUBITUS POSITION IN THE THORACOSCOPIC ESOPHAGECTOMY
28.	2013/04/08	Development of novel targeted therapies for non-small cell carcinoma by novel Midkine inhibitors （Poster notice，General）
29.	2013/03/01	Feasibility of S-1 for adjuvant chemotherapy of gastric cancer; 4-week S-1 administration followed by 2-week rest vs. 2-week administration followed by 1-week rest （Speech，General）
30.	2012/09/21	Identification of novel Midkine inhibitors for the treatment of non-small cell lung cancer （Speech，General）
31.	2012/04/13	Short-term hemodynamic changes in recipients with hemi-portocaval shunt （Panelist at Symposium/Workshop (Other)）
32.	2012/04/04	Targeting KRAS lung cancer in vivo by pulmonary surfactant-medicated gene transfer （Poster notice，General）
33.	2012/04/02	HSP90 inhibitor NVP-AUY922 exhibits the potent antiproliferative effect in gastrointestinal cancer cells with a lack of PTEN expression （Poster notice，General）
34.	2011/04/04	Antitumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. （Poster notice）
35.	2011/04/04	Inhibition of mammalian target of rapamycin(mTOR)signaling by Temsirolimus as a potential therapeutic strategy for esophageal cancer treatment. （Poster notice）
36.	2010/09/24	Targeting KRAS lung cancer in vivo by pulmonary surfactant-mediated gene transfer （Panelist at Symposium/Workshop (Other)）
37.	2010/09/23	Experimental approach to control peritoneal dissemination of colon cancer by targeting FAK. （Panelist at Symposium/Workshop (Other)）
38.	2010/09/22	Esophageal cancer exhibits a resistance to a novel IGF-1R inhibitor NVP-AEW541 with a maintained Ras-MAPK activity. （Poster notice，General）
39.	2010/09/01	Analysis of Surgically Resected Case of Barrett's ESophageal Carcinoma. （Poster notice，General）
40.	2010/04/20	The establishment of a new mouse model with orthotopic esophageal cancer showing the esophagostenosis
41.	2010/04/19	N-cadherin down-rgulation has antitumor effects in esophageal cancer
42.	2010/04/19	The anti-tumor effect of TAE226 , dual inhibitor of fak and IGF-IR , on non-small-cell lung cancer with EGFR mutain
43.	2010/04/18	Adenoviral mediated expression of Omomyc induced growth inhibition and apoptosis in lug cancer expressing Myc
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■ Professional Organizations

1.		Japan Surgical Society
2.		the Japanese Society of Gastroenterological Surgery
3.		The Japanese Society of Gastroenterology
4.		The Japan Gastroenterological Endoscopy Society
5.		The Japan Society of Clinical Oncology
6.		Japan Surgical Association
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