Faculty Information - Naoko Takei

Present specialized field

BooK

Journal

Presentation

（Last updated : 2023-11-09 12:16:06）

Naoko Takei
Department Kawasaki Medical School Kawasaki Medical School, Department of Hygiene,

Position Assistant Professor

■ Present specialized field

Hygiene and public health: including laboratory approach, Immunology

■ BooK

1.	2021	Asbestos fiber and immunological effects: Do immunological effects play any role in asbestos-related diseases?, Malignant Pleural Mesothelioma
2.	2019	Biological effects of negatively charged-particle dominant indoor air conditions., Charged Particles.
3.	2019	Immune alteration caused by fibrous and particulate environmental substances., Environmental Factors affecting Human Health.
4.	2019	Trials for health promotion by indoor environment modifications., Indoor Environment and HealthH
5.	2018/11	Alteration of various lymphocytes by particulate and fibrous substances., Lymphocyte
6.	2017	A new method to determine natural killer cell activity without target cells, NATURAL KILLER CELLS
7.	2017	Alteration of perforin status caused by asbestos exposure in CTL and NK cellss, Advances in Medicine and Biology
8.	2016	Effects of Asbestos Fibers on Human Cytotoxic T Cells, Biological Effects of Fibrous and Particulate Substances
9.	2016	Immunological risks caused by fibrous and particulate substances., Environmental Health Risks
10.	2016	Reduction of anti-tumor immunity caused by asbestos exposure, Asbestos: Risk Assessment, Health Implications and Impacts on the Environment.
11.	2016	Reduction of anti-tumor immunity caused by asbestos exposure., In. Asbestos: Risk Assessment, Health Implications and Impacts on the Environment.
12.	2016	Silica-induced immunotoxicity: chronic and aberrant activation of immune cells, In: Allergy and Immunotoxicology in Occuaptional Health, (Series Title: Current Topics in Environmental Health and Preventive Medicine)
13.	2016	Suppressive effects of asbestos exposure on the human immune surveillance system., In: Allergy and Immunotoxicology in Occuaptional Health, (Series Title: Current Topics in Environmental Health and Preventive Medicine)
14.	2015	Effects of Asbestos Fibers on Human Cytotoxic T Cells, Biological Effects of Fibrous and Particulate Substances
15.	2015	T Cell Alteration Caused by Exposure to Asbestos., Biological Effects of Fibrous and Particulate Substances
16.	2014	Immunostimulation by silica particles and the development of autoimmune dysregulation., Immunostimulation
17.	2013	Asbestos-induced mesothelioma: Tumor escape and alteration of immune surveillance., Recent Research Developments in Immunology
18.	2013	Immunological effects of silica., Encyclopedia of Metalloproteins
19.	2011/09	Immunological effects of silica and related dysregulation of autoimmunity., Autoimmune Disorders-Pathogenetic Aspects
20.	2010/10	Dysregulation of Autoimmunity Caused by Silica Exposure: Fas-Mediated Apoptosis in T Lymphocytes Derived from Silicosis Patients., Autoimmune Disorders: Symptoms, Diagnosis and Treatment.
21.	2009/10	Establishment of Negatively-charged Indoor Air Conditions and their Biological Effects., Buildings and the Environment
22.	2009/10	Immunological effects of Asbestos., Asbestos: Risks, Environment and Impact.
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■ Journal

1.	2021/04/19	Effect of IL-15 addition on asbestos-induced suppression of human cytotoxic T lymphocyte induction.
2.	2021/03/30	Increased production of matrix metalloproteinase-7 (MMP-7) by asbestos exposure enhances tissue migration of human regulatory T-like cells.
3.	2021/02/02	Ingredients such as trehalose and hesperidin taken as supplements or foods restore changes in human T cells suggesting reduction of anti-tumor immunity caused by asbestos exposure.
4.	2020/10/08	Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes.
5.	2020/09/23	The effect of asbestos fibers on human T cells.
6.	2020/05/30	Increased production of matrix mettalloproteiase-7 (MMP-7) by asbestos exposure enhances tissue migration of human regulatory T-like cells
7.	2020/05	Enhanced expression of nicotinamide nucleotide transhydrogenase (NNT) and its role in a human T cell line continuously exposed to asbestos.
8.	2020	Structure-based design of gRNA for Cas13.
9.	2019	Role of nephronectin in pathophysiology of silicosis.Special Issue "Macrophages in Inflammation 2019"
10.	2018/10	Decrease in intracellular perforin levels and IFN-gamma production in human CD8+ T cell line following long-term exposure to asbestos fibers.
11.	2018	Aberrant expression of FoxP3 in a human T cell line possessing regulatory T cell-like function and exposed continuously to asbestos fibers.
12.	2018	Decrease in serum amyloid A (SAA) protein following three-month stays under negatively charged particle-dominant indoor air conditions.
13.	2018	Inflammatory alteration of human T cells exposed continuously to asbestos.
14.	2018	Skewing T helper cells exposed to asbestos fibers toward reduction of tumor immunity or activation of autoimmunity.
15.	2017/04	Silicosis and autoimmunity
16.	2017	Accelerated cell-cycle progression of human regulatory T cell-like cell line caused by continuous exposure to asbestos fibers.
17.	2017	Alteration of immune cells in silicosis: Roles in development of autoimmunity and lung fibrosis.
18.	2017	Clinical evaluation of CENP-B and Scl-70 autoantibodies in silicosis patients.
19.	2017	Induction of IL-17 production from human peripheral blood CD4+ cells by asbestos exposure.
20.	2017	Search for biomarkers of asbestos exposure and asbestos-induced cancers in investigations of the immunological effects of asbestos.
21.	2017	Titanate nanosheets cause caspase-dependent apoptosis of human immune cells with giant vacuole formation through endosomal defect in monocytes.
22.	2016/04	The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.
23.	2016	Biological effects of cloth containing specific ore powder in patients with pollen allergy.
24.	2016	Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment.
25.	2016	FoxO1 Regulates Apoptosis Induced by Asbestos in the MT-2 Human T-Cell Line
26.	2016	Silica and mineral silicates causing autoimmune diseases.
27.	2016	The suppressed induction of human mature cytotoxic T lymphocytes caused by asbestos is not due to Interleukin-2 insufficiency.
28.	2015	Biological effects of refractory ceramic fiber
29.	2015	Enhancement of NK Cell Cytotoxicity Induced by Long-Term Living in Negatively Charged-Particle Dominant Indoor Air-Conditions.
30.	2015	Enhancement of regulatory T cell-like suppressive function in MT-2 by long-term and low-dose exposure to asbestos.
31.	2015	Exposure to negaively-charged particle domitant air-conditions on human lymphocytes in vitro activates immunological responses.
32.	2015	Functional alteration of natural killer cells and cytotoxic T lymphocytes upon asbestos exposure and in malignant mesothelioma patients.
33.	2015	Investigating methods regarding diagnostic and prognostic biomarkers for malignant mesothelioma.
34.	2014/09	Chronic exposure to asbestos enhances TGF-bata1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2
35.	2014/08	Silica exposure and altered regulation of autoimmunity
36.	2014/06	Functional properties of CD8+ lymphocytes in patients with pleural plaque and malignant mesothelioma
37.	2013/09	Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos.
38.	2013/07	Effect of asbestos exposure on differentiation of cytotoxic T lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells.
39.	2013/05	Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases.
40.	2013	Exploration of biomarkers for asbestos exposure and occurrence of malignant mesothelioma based on the immunological effects of asbestos.
41.	2012/07	Environmental factors producing autoimmune dysregulation-Chronic activation of T cells caused by silica exposure.
42.	2012/07	Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell
43.	2012	Asbestos-Induced Cellular andMolecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis
44.	2012	Review of reduced tumor immunity caused by asbestos exposure to immunocompetent cells such as T and NK cells.
45.	2011/10	Asbestos Induces Reduction of Tumor Immunity
46.	2011/10	Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients.
47.	2011/09	Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-2.
48.	2011/06	Quick detection of overexpressed genes caused by myeloma-specific chromosomal translocations using multiplex RT-PCR.
49.	2011/01	Suppressive effect of asbestos on cytotoxicity of human NK cells.
50.	2010/10	Dysregulation of the Immune System Caused by Silica and Asbestos.
51.	2010/10	Reductive alteration of the regulatory function of the CD4(+)CD25(+) T cell fraction in silicosis patients.
52.	2009/12	Decrease in phosphorylation of ERK following decreased expression of NK-cell activating receptors in human NK cell line exposed to asbestos.
53.	2009/09	Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers.
54.	2009/07	Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases.
55.	2009/06	The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model.
56.	2009/06	Two weeks of abidance in negatively-charged air conditions causes alteration of natural killer cell function.
57.	2009/03	The biological effects of negatively-charged indoor aire conditions.
58.	2009/02	Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients?
59.	2009/01	Effects of Vitamin D receptor (VDR) gene polymorphism on low-resistance training using exercise machines (“Power rehabilitation”) as rehabilitation program.
60.	2009/01	Soluble interleukin-2 receptor as an indicator of immunological disturbance found in silicosis patients.
61.	2008/10	Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level.
62.	2008/05	Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from cerebral cortices of SAMP10 mice: a model for age-dependent neurodegeneration.
63.	2008	Immunological changes in mesothelioma patients and their experimental detection.
64.	2008	Lifestyle and T-helper 1 and 2 related cytokines in healthy volunteers
65.	2008	Negatively-charged air conditions and responses of the human psycho-neuro-endocrino-immune network.
66.	2007	Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse.
67.	2004	Induction of mouse c-src in RAW264 cells is dependent on AP-1 and NF-kappaB and important for the progression to multinucleated cell formation.
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■ Presentation

1.	2018/04/13	Effects of continuous exposure to asbestos fibers on human T cell: on the viewpoint of anti-tumor immunity （Speech）
2.	2018/04	Effects of IL-15 addition on the suppressed induction of CTL upon exposure to asbestos. （Poster notice，General）
3.	2018/04	Effet of long-term exposure to asbestos on functional properties of human CD8+ T cell line. （Poster notice，General）
4.	2018/03/12	The Functional Analysis of Human CD8+ T Cell Line with Long-Term Exposure to Chrysotile Asbestos Fibers （Poster notice，General）
5.	2017/12/14	The analysis for function of human CD8+T cell line with and without long-term exposure to asbestos fibers （Poster notice，General）
6.	2017/03/15	Differential Effects of IL-2 and IL-15 Addition on Numbers and Granzyme B Level in CD8+ Lymphocytes Exposed to Asbestos during MLR （Poster notice，General）
7.	2017/03/15	Increased Proliferation of Mesothelial Cells under the Influence of Asbestos-Exposed Peripheral Blood Mononuclear Cells （Poster notice，General）
8.	2017/03/14	Effect of Short-Term and Long-Term Exposure of Asbestos on Human T Cell Line MT-2 （Poster notice，General）
9.	2016/12/05	Differential effects of IL-2 and IL-15 on the suppressed induction of CTL upon exposure to asbestos （Poster notice，General）
10.	2016/10/13	Function and cell cycle in regulatory T cell like human cell line continuously exposed to asbestos
11.	2016/03/14	Alteration of Oxidative Phospholylation-related Complexes in Human T Cell Lines, MT-2 and its Sublines Continuously Exposed to Asbestos Fibers, by Transient Exposure to Asbestos （Poster notice，General）
12.	2016/03/14	Chronic Exposure to Chrysotile Asbestos Induces Il-17 Production in Cultured Human Peripheral CD4+ T Cells in vitro （Poster notice，General）
13.	2016/03/14	Effect Of IL-2 Addition on Granzyme B Expression and Proliferation in CD8+ Lymphocytes Exposed to Asbestos During MLR （Poster notice，General）
14.	2016/03/14	Study for Immunological Importance of Increased Plasma Decoy Receptor 3 Level in Silicosis （Poster notice，General）
15.	2016/03/14	The Role of Transcription Factor FoxP3 in the Asbestos-Induced Apoptosis in MT-2 Cells （Poster notice，General）
16.	2016/03/14	Vacuole Formation And Caspase-dependent Apoptosis In Human Monocytes Caused By Exposure To Titanate Nanosheet （Poster notice，General）
17.	2015/10/08	Functional features of CD8+ lymphocytes in pleural plaque and mesothelioma. （Speech）
18.	2015/06/02	Functional Enhancement caused by Asbestos Exposure in human regulatory T cell Line. （Speech）
19.	2015/06	Analysis between blood DcR3 level, autoantibodies and respiratory score in silicosis patients.
20.	2015/06	Characteristics of tumor immunity and inflammatory cytokine production in patients with pleural plaque and malignant mesothelioma.
21.	2015/06	Continuous exposure to crocidolite on a human T cell line causes resistant to asbestos-induced apoptosis similar to chrysotile exposure. （Poster notice，General）
22.	2015/06	Direct long-term exposure of asbestos accelerates cell cycle regulation and alters cell survival of Treg model cell line MT-2
23.	2015/06	Effect of IL-2 addition on the suppressed induction of human CTL in mixed lymphocyte reactions upon exposure to asbestos （Poster notice）
24.	2015/06	Functional properties of CD8+ lymphocytes in asbestos-exposed patients with pleural plaque and malignant mesothelioma. （Speech）
25.	2015/06	Functional similarity and difference in peripheral blood CD4+ and CD8+ lymphocytes and plasma cytokines between silicosis and systemic scleroderma.
26.	2015/06	Immunological characteristics in asbestos and silica-caused disease. （Speech，Panelist at Symposium/Workshop (Other)）
27.	2015/06	The Role of FoxO1 and FoxP3 in Asbestos-induced Apoptosis of MT-2 Cells.
28.	2014/12/11	Immunological similarity and difference between individuals positive for pleural plaque with malignant mesothelioma, rebealed by analysis for mRNA levels. （General）
29.	2014/12/11	Induction of IL-17 priduction from human peripheral CD4+ cells by asbestos-exposure. （General）
30.	2014/12/11	Plasma DcR3 which inhibits Fas-induced apoptosis is increased in silicosis patients who are non-onset autoimmune diseases. （General）
31.	2014/10/31	Immune stimulation cansed by silica and dysregulation of autoimmunity （General）
32.	2014/09/26	Continuous exposure to asbestos on human T cell line accelerates cell cycle progression thrugh reduced FoxO1 expression. （Speech，General）
33.	2014/09/03	Analysis of blood DcR3 concentration and its correlation to autoantibodies in silicosis patients. （General）
34.	2014/09/03	Immunological similarity and difference observed in analyses for mRNAs, cell surface molecules and plasma cytokines between silicosis and systemic scleroderma （General）
35.	2014/09/03	Increased NK activity by negatively-charged particles dominant indoor air condition. （General）
36.	2014/09/03	Molecular mechanisms of asbestos-induced apoptosis in MT-2 cells. （General）
37.	2014/03/27	The characteristics of activated lymphocytes in silicosis differing in Th17 phenotype from systemic sclerosis （Speech，General）
38.	2014/03/25	Alteration of cytoskeltal molecules in as human T cell line caused by continuous exposure to chrysotile asbestos （Poster notice，General）
39.	2014/03/25	Analysis of blood DcR3 concentration andits correlation to clinical paramaters of autoimmune diseases in silicosis patients （Poster notice，General）
40.	2013/12/13	Continuous exposure of asbestos on Treg model cell line MT-2 affects cell cycle progression and cell survival （Poster notice，General）
41.	2013/12/13	Immunological analysis for patients with silicosis or systemic scleroderma （Poster notice，General）
42.	2013/12/13	Molecular basis of asbestos-induced apoptosis in MT-2 cells （Poster notice，General）
43.	2013/12/11	Change of cytoskeletal molecules in a human T cell line exposed to chrysotile asbestos. （Poster notice，General）
44.	2013/10/28	Down-regulation of FoxO1 in MT-2 cells induced by long-term exposure to asbestos. （Poster notice，General）
45.	2013/10/28	Dysregulation of autoimmunity and chronic activation of T cells caused by silica exposure （Speech，General）
46.	2013/10/28	Granzyme B and perforin levels of Cd8+ lymphocytes in patients with pleural plaque or mesothelioma （Poster notice，General）
47.	2013/10/28	Long-term exposure of asbestos affects cell cycle and cell death in Treg model cell line MT-2. （Poster notice，General）
48.	2013/10/28	Suppressive effects of exposure to multi-walled carbon nanotubes and asbestos on NK cell function. （Poster notice，General）
49.	2013/03/11	Difference in functional property of CD8+ lymphocytes between patients with pleural plaque and malignant mesothelioma. （Poster notice，General）
50.	2013/03/10	Effects of asbestos exposure on regulatory role of NK cells for expanded autologous CD4+ T cells. （Poster notice，General）
51.	2013/03/10	Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell （Poster notice，General）
52.	2012/09/19	Asbestos-induced cellualr alteration of immunocompetent cells and the relationship with inflammation and carcinogenesis. （Speech，General）
53.	2012/03/19	Effects of asbestos exposure on induction of cytotoxic T lymphocytes in mixed lymphocyte reactions and cytotoxic potential of CD8+ lymphocytes in asbestos-exposed people. （Poster notice，General）
54.	2012/03/13	IFN-γ, granzyme B and perforin-positive cells of CD8+ lymphocytes in asbestos-exposed people with pleural plaque. （Poster notice，General）
55.	2010/09/02	Suppressive effects of asbestos-exposure on the differentiation of human cytotoxic T lymphocytes, accompanied with decrease in IFN-γ and TNF-α. （Poster notice，General）
56.	2010/04/08	Analysis of immune index in asbesots-related disease. （Poster notice，Panelist at Symposium/Workshop (Other)）
57.	2010/04/08	Differentiation into human cytotoxic T lymphocytes are suppressed under exposure to asbestos. （Poster notice，General）
58.	2010/04/08	Immunological effects of silica and asbestos. （Speech，Panelist at Symposium/Workshop (Other)）
59.	2010/04/08	Suppressive effect of asbestos on cytotoxicity of human NK cells. （Speech，Panelist at Symposium/Workshop (Other)）
60.	2010/03/07	Suppressive effects of asbestos-ezposure on the differentiation into uhman cytotoxic T lymphocytes. （Poster notice，General）
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