Faculty Information - Yasumitsu Nishimura

（Last updated : 2016-05-25 15:05:14）

Yasumitsu Nishimura
Department Kawasaki Medical School Kawasaki Medical School, Department of Hygiene,

Position Associate Professor

■ Present specialized field

Immunology, Hygiene and public health: including laboratory approach (Key Word：immunology, asbestos, NK-cell, senescence, aging)

■ BooK

1.	2010/10	Dysregulation of Autoimmunity Caused by Silica Exposure: Fas-Mediated Apoptosis in T Lymphocytes Derived from Silicosis Patients., Autoimmune Disorders: Symptoms, Diagnosis and Treatment.
2.	2009/10	Establishment of Negatively-charged Indoor Air Conditions and their Biological Effects., Buildings and the Environment
3.	2009/10	Immunological effects of Asbestos., Asbestos: Risks, Environment and Impact.

■ Journal

1.	2011/06	Quick detection of overexpressed genes caused by myeloma-specific chromosomal translocations using multiplex RT-PCR.
2.	2010/10	Dysregulation of the Immune System Caused by Silica and Asbestos.
3.	2010/10	Reductive alteration of the regulatory function of the CD4(+)CD25(+) T cell fraction in silicosis patients.
4.	2009/12	Decrease in phosphorylation of ERK following decreased expression of NK-cell activating receptors in human NK cell line exposed to asbestos.
5.	2009/09	Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers.
6.	2009/07	Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases.
7.	2009/06	Two weeks of abidance in negatively-charged air conditions causes alteration of natural killer cell function.
8.	2009/03	The biological effects of negatively-charged indoor aire conditions.
9.	2009/02	Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients?
10.	2009/01	Effects of Vitamin D receptor (VDR) gene polymorphism on low-resistance training using exercise machines (“Power rehabilitation”) as rehabilitation program.
11.	2009/01	Soluble interleukin-2 receptor as an indicator of immunological disturbance found in silicosis patients.
12.	2008	Immunological alterations found in mesothelioma patients and supporting experimental evidences.
13.	2008	Immunological changes in mesothelioma patients and their experimental detection.
14.	2008	Lifestyle and T-helper 1 and 2 related cytokines in healthy volunteers
15.	2008	Negatively-charged air conditions and responses of the human psycho-neuro-endocrino-immune network.
16.	2007/10	Long-lasting production of TGF-beta1 by alveolar macrophages exposed to low doses of asbestos without apoptosis.
17.	2007/08	Immunological effects of silica and asbestos.
18.	2007/03	Mouse model of paraquat-poisoned lungs and its gene expression profile.
19.	2007	Keynote lecture in the 13th Japanese Society of Immunotoxicology (JSIT 2006) --- Pathophysiological Development and Immunotoxicology: what we have found from the researches related to the silica and silicate such as asbestos---.
20.	2007	Pathophysiological Development and Immunotoxicology: what we have found from the researches related to the silica and silicate such as asbestos.
21.	2006/11	TRAIL expression up-regulated by interferon-gamma via phosphrylation of STAT1 induces myeloma cell death
22.	2006/10	Expression of the T cell receptor Vβ repertoire in a human T cell resistant to asbestos-induced apoptosis and peripheral blood T cells from patients with silica and asbestos-related diseases.
23.	2006/07	Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells.
24.	2006/05	Alterations of Fas and Fas-related molecules in patients with silicosis.
25.	2006/04	Reduced function of CD4+CD25+ regulatory T cell fraction in silicosis patients.
26.	2006	Asbestos-related carcinogenesis and immunological effects.
27.	2005/02	Production of nitric oxide elevates nitrosothiol formation resulting in decrased glutathione in macrophages exposed to asbestos or asbestos substitutes.
28.	2004	Functional analysis of the splenic CD4+ T cells from SAMP1 , a strain of senescence-accelerated mouse : short-lasting production of IL-2 and increased degration of its mRNA. Clinical Investigative Medicine.
29.	2004	The stability of interleukin-2 mRNA transcribed in splenic CD4+ T cells from SAMP1 mice.
30.	2002/07	Insufficient interleukin-2 production from splenic CD4+ T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse.
31.	2001/01	Effects of aging and blood pressure on the structure of the thoracic aorta in SAM mice: a model of age-associated degenerative vascular changes.
32.	1999/07	Aminoguanidine supplementation delays the onset of senescence in vitro in dermal fibroblast-like cells from senescence-accelerated mice.
33.	1998/09	An early stage mechanism of the age-associated mitochondrial dysfunction in the brain of SAMP8 mice; an age-associated neurodegeneration animal model.
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■ Belonging society

1.	1995/10～	Japan Society for Biomedical Gerontology
2.	1996/03～	The Council for SAM Research
3.	1999/12～	Japanese Society for Immunology
4.	2003/03～	The Japanese Society for Hygiene
5.	2003/04～	Japan Society for Occupational Health
6.	2005/09～	The Japanese Society of Immunotoxicology
7.	2006/12～	Japanese Society for Molecular Preventive and Environmental Medicine
8.	2010～	Japanese Society of Interferon & Cytokine Research
9.	2011/05～	Japanese Association for Cancer Prevention
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