Faculty Information - Ken Hashimoto

Current specialization

Journal Articles

Presentations

（Last updated : 2026-09-14 08:45:16）

Ken Hashimoto
Department Kawasaki Medical School Kawasaki Medical School, Department of Physiology 1,

Position Associate Professor

■ Current specialization

Clinical pharmacy, Biomedical engineering, Developmental biology, Evolutionary biology, Cardiology

■ Journal Articles

1.	2026/09/10	Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.
2.	2026/08/29	Phosphorescence lifetime microscopy and contrast-enhanced ultrasound imaging revealed strong left-to-right intraventricular shunt in anesthetized Xenopus laevis.
3.	2025/11	CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress.
4.	2025/07/09	Cartilaginous fish and mammalian connectin evolved independently from an ancestral bony fish-like structure
5.	2025/04/27	The Ancestor and Evolution of the Giant Muscle Protein Connectin/Titin
6.	2024/06/14	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.
7.	2024/04/21	Comparative analysis of ventricular stiffness across species.
8.	2024/03/11	Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
9.	2024	Precaudal Vertebrae in the Postcranial Region of Moray Eels Form Ventral Processes.
10.	2022/11/04	Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon
11.	2022/08/20	Oxygen environment and cardiac regeneration
12.	2022/05/20	Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
13.	2018/08/17	Nuclear connectin novex-3 promotes proliferation of hypoxic foetal cardiomyocytes.
14.	2018/05	Turtle spongious ventricles exhibit more compliant diastolic property and possess larger elastic regions of connectin in comparison to rat compact left ventricles
15.	2017/06	Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.
16.	2017/01	Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle
17.	2016/09	Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling
18.	2015/12	Left ventricular mechanics and myocardial calcium dynamics in short-term and long-term hyperthyroid mice
19.	2013/03	Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-Bridge Formation in Hypertrophied Rat Hearts Induced by Chronic beta-Adrenergic Stimulation
20.	2012/12	Calcium influx through the TRPV1 channel of endothelial cells (ECs) correlates with a stronger adhesion between monocytes and ECs
21.	2012	Live-cell visualization of the trans-cellular mode of monocyte transmigration across the vascular endothelium, and its relationship with endothelial PECAM-1.
22.	2011/03	Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions
23.	2011	Cadherins in potential link between atherosclerosis and cancer
24.	2010/09	An Experimental Model for Studying Molecular Behavior of Platelet-Endothelial Cell Adhesion Molecule-1 during Mechanical Interactions between Monocytes and Vascular Endothelial Cells
25.	2010/04	Altered Nano/Micro-Order Elasticity of Pulmonary Artery Smooth Muscle Cells of Patients with Idiopathic Pulmonary Arterial Hypertension
26.	2009/03	Evaluation of Coronary Endothelial Function by Catheter-Type NO Sensor in High-Fat-Diet-Induced Obese Dogs
27.	2009	Measurement and finite element modeling of the force balance in the vertical section of adhering vascular endothelial cell.
28.	2008/07	The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes
29.	2008/04	Intracellular Ca²⁺ responses in cultured endothelial cells to mechanical stimulation by laser tweezers
30.	2007/10	Oxidized LDL specifically promotes the initiation of monocyte invasion during transendothelial migration with upregulated PECAM-1 and downregulated VE-cadherin on endothelial junctions.
31.	2007/06	Assessment of the mechanical properties of the nucleus inside a spherical endothelial cell based on microtensile testing.
32.	2005/04	Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability.
33.	2004/11	Direct observation and quantitative analysis of spatiotemporal dynamics of individual living monocytes during transendothelial migration
34.	2002/11	Measurements of endothelial cell-to-cell and cell-to-substrate gaps and micromechanical properties of endothelial cells during monocyte adhesion.
35.	2000	Mechanical stress and actin filament dynamics in cultured endothelial cell.
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■ Presentations

1.	2019/03/30	Evolutional relationship between hearts and elastic protein connectins （Poster notice，General）
2.	2019/03/30	Comparison of cardiomyocyte kinetics of rat left ventricle and turtle ventricle （Poster notice，General）
3.	2019/03/29	Nuclear connectin novex-3 is essential for proliferation of hypoxic fetal cardiomyocytes （Poster notice，General）
4.	2018/06/19	Comparative study of tensile properties of ventricular cardiomyocytes of rat and turtle （Poster notice，General）
5.	2018/03/30	Comparison of extensibility of rat compact left ventricle and turtle spongious ventricle （Poster notice，General）
6.	2018/03/29	Elastic structures of connectin shortened in coronary circulation hearts （Poster notice，General）
7.	2017/03/29	Effect of NCX1 on the mislocalization of junctophilin-2 in failing heart induced by pressure-overload （Poster notice，General）
8.	2016/11/17	Relationship between heart evolution and elastic structure of connectin in vertebrate （Poster notice，General）
9.	2016/04/28	Elastic structure of connectin in the hearts with coronary and non-coronary circulation （Poster notice，General）
10.	2016/04/27	Fam64a is essential for low oxygen-induced fetal cardiomyocyte proliferation （Poster notice，General）
11.	2016/04/27	Effects of inducing Na+/Ca2+ exchanger 1 expression on the microstructure in cardiomyocytes during progression of heart failure （Poster notice，General）
12.	2016/03/23	The role of NCX1 in T-tubule remodeling during progression of heart failure induced by pressure overload （Poster notice，General）
13.	2016/03/22	Elastic structures of cardiac connectin in the vertebrate hearts with coronary and sinusoidal circulation （Poster notice，General）
14.	2016/03/22	Identification of critical molecule mediating oxygen-dependent cell cycle arrest of cardiomyocytes around birth in mice （Poster notice，General）
15.	2016/01/09	Mechanical signaling via TRPV2 in cardiomyocytes （Speech，General）
16.	2015/05/09	Analysis of cardiac titin isoform switch around birth （Poster notice，General）
17.	2015/05/09	TRPV2 is critical for the cardiac function in adult mice （Poster notice，General）
18.	2015/03/21	Analysis of developmentally regulated cardiac titin isoform switch at birth. （Poster notice，General）
19.	2014/06/24	Preliminary analysis of cell cycle regulation in cardiomyocytes. （Speech，General）
20.	2014/03/18	Preliminary analysis of cell cycle regulation in cardiomyocytes. （Poster notice，General）
21.	2013/11/02	The role of Sodium/Calcium exchanger in maintaining T-tubule structure （Speech，General）
22.	2013/03/27	Preliminary analysis of differentiation and proliferation program of cardiomyocytes in developmental stages. （Poster notice，General）
23.	2012/10/25	Realtime observation of actindynamics in living and migrating monocytic cells with Lifeact-GFP fusion protein. （Poster notice，General）
24.	2011/04/29	Observation of leukocyte migration induced by chemoattractant injection from micropipette
25.	2011/03/28	Monocyte trans-endothelial migration facilitates subsequent transmigration with increased PECAM-1 and decreased VE-cadherin on endothelial junctions. （Poster notice，General）
26.	2010/09	In vitro bioimaging of monocyte trans-endothelial migration in early atherogenesis （Speech，Panelist at Symposium/Workshop (Other)）
27.	2010/08	Monocyte trans-endothelial migration induces PECAM-1 accumulation and VE-cadherin reduction at the surface of vascular endothelial cells
28.	2009/08	ENDOTHELIAL TRANSIENT RECEPTOR POTENTIAL VANILLOID CHANNEL 1 AND SMALL CONDUCTANCE POTASSIUM CHANNEL STRENGTHENED ADHESION OF MONOCYTE （Poster notice，General）
29.	2009/03	Increased Cardiomyocyte Elasticity in the Transverse Direction in Hypertrophied Rat Hearts Induced by Chronic β-Adrenergic Stimulation. （Speech，General）
30.	2008/12	Local Dynamic Recruitment of Endothelial PECAM-1 to Transmigrating Monocytes. （Speech，General）
31.	2008/03	Local dynamic recruitment of endothelial PECAM-1 to transmigrating monocytes during paracellular diapedesis. （Speech，General）
32.	2008/03	Increased cardiomyocyte stiffness of the transverse direction in the rat heart with hypertrophy induced by chronic β-adrenergic stimulation. （Speech，General）
33.	2007/09	Effects of IL-1beta and oxLDL on micromechanics of endothelium related with monocyte transmigration. （Poster notice，General）
34.	2007/09	The elastic modulus of osteoblasts and osteocytes. （Poster notice，General）
35.	2006/06/28	Micro-elasticity of osteoblast and osteocyte. （Poster notice，General）
36.	2006/04	Oxidized LDL specifically promotes the initiation of monocyte invasion at cell-cell junctions by upregulating PECAM-1. （Speech，General）
37.	2005/12	Oxidized LDL specifically promotes monocyte post-adhesion dynamics on endothelium, but not invasion itself at junctions, or subendothelial migration after invasion. （Speech，Panelist at Symposium/Workshop (Other)）
38.	2005/09	Oxidized LDL specifically promotes monocyte post-adhesion dynamics on endothelium, but not invasion itself, or subendothelial migration after invasion. （Poster notice，General）
39.	2004/05	Direct single-cell imaging of monocyte transendothelial migration with living samples. （Speech，Panelist at Symposium/Workshop (Other)）
40.	2004/03	Micro-mechanical function analysis of reversible immortalized human aortic endothelial cells. （Speech，General）
41.	2004/03	Increases in the endothelial cell-to-substrate gap and endothelial cell deformability after monocyte adhesion -importance of nano/micro-mechanics of endothelial cells in the monocyte transmigration process - （Speech，General）
42.	2003/12	Direct observation and quantitative analysis of spatiotemporal dynamics of individual living monocyte during transendothelial migration （Speech）
43.	2003/12	Measurement of the effect of estrogen on nano/micro-mechanics of vascular endothelial cells. （Poster notice，General）
44.	2003/12	Micro-mechanical and physiomic analysis of reversible immortalized human aortic endothelial cells. - analysis with nano/micro technologies - （Poster notice，General）
45.	2003/08	Three-dimensional and time-sequential observation of single living monocyte transmigrating through endothelium. （Speech，General）
46.	2003/08	Changes in nano/micro-mechanics of endothelial cells after monocyte adhesion （Speech，General）
47.	2003/08	Production of nitric oxide and eNOS expression decrease at curvature of renal artery - physiomic approach to atherogenesis. （Speech，Panelist at Symposium/Workshop (Other)）
48.	2002/11	Altered Nano/Micro-Order Mechanical Property Of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension.
49.	2002/10	Altered Nano/Micro-Order Mechanical Property Of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension.
50.	2002/08	Ca2+ responses and its propagation in cultured endothelial cells to cytosolic mechanical stimulation by laser tweezers. （Speech）
51.	2002/08	Altered nano-order, micro-mechanical property of pulmonary artery smooth muscle in primary pulmonary hypertension. （Speech）
52.	1999/09	Mechanical stress and actin filament dynamics in cultured endothelial cell.
53.	2025/09/11	Evolutionary convergence of the heart in Mammals and Cephalopods: shortening of connectin/titin in ventricular myocardium with increased activity （Poster notice，General）
54.	2025/09/05	Integrated analysis of squid heart structure and elastic protein connectin （Poster notice，General）
55.	2025/03/19	Evolutionary and physiological analysis of molluscan hearts based on the muscle elastic protein connectin （Speech，General）
56.	2022/12/03	Study of the heart health in aqua-cultured fish （Poster notice）
57.	2022/09/10	Evolution of an unique blood pump system in the jawless lamprey （Speech，General）
58.	2022/03/18	Elucidation of mammalian heart evolution by multiscale analysis of the lobster heart （Poster notice，General）
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