Faculty Information - Toyotaka Yada

（Last updated : 2024-09-10 11:39:22）

Toyotaka Yada
Department Kawasaki University of Medical Welfare ,

Position Professor with Special Assignment

■ BooK

1.	2003	Important role of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in animals and humans, EDHF 2002
2.	2004	Beneficial role of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microcirculation in vivo, Microcirculation annual 2004
3.	2003	Functional role of capillaries in reactive hyperemia by direct observation with a pencil-lens intravital videomicroscope, Microcirculation annual 2003
4.	2003	Hydrogen peroxide, an endogenous EDHF, plays an crucial role in coronary autoregulation in vivo, Microcirculation annual 2003

■ Journal

1.	2009/12	Impaired endothelial function may be due to decreased aortic tetrahydrobiopterin, assessed by a new flow-mediated vasodilation in vivo in hypercholesterolemic/atherogenic mice
2.	2008/08	Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice
3.	2008/05	Coronary microcirculation in the beating heart
4.	2008/12	Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy
5.	2007/06	Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis.
6.	2008/01	Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo
7.	2008/03	Oral administration of tetrahydrobiopterin attenuates testicular damage by reducing nitric oxide synthase activity in a cryptorchid mouse model
8.	2007/09	Important role of endogenous hydrogen peroxide in pacing-induced metabolic coronary vasodilation in dogs in vivo
9.	2007/06	Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats
10.	2006/09	Cardioprotective role of endogenous hydrogen peroxide during ischemia-reperfusion injury in canine coronary microcirculation in vivo
11.	2006/06	Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase.
12.	2007/01	Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments
13.	2006/04	Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo
14.	2005	Systemic nitric oxide production rate during hemodialysis and its relationship with nitric oxide-related factors
15.	2005/03	Direct observation of epicardial coronary capillary hemodynamics during reactive hyperemia and during adenosine administration by intravital video microscopy.
16.	2005/02	Exogenous NO suppresses flow-induced endothelium-derived NO production because of depletion of tetrahydrobiopterin
17.	2005/02	Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/ reperfusion injury in canine coronary microcirculation in vivo
18.	2003/05	In vivo visualization of subendocardial arteriolar response in renovascular hypertensive hearts
19.	2003/05	Measurement of acetylcholine-induced endothelium-derived nitric oxide in aorta using a newly developed catheter-type nitric oxide sensor
20.	2003/02	Hydrogen peroxide, an endogenous endothelium-derived hyperpolarizing factor, plays an important role in coronary autoregulation in vivo
21.	2001	Tissue Engineering for Therapeutic
22.	2001	Coronary microcirculation-Central Dogma and the Trend of Adenosine
23.	2000	Intramyocardial influences on blood flow distributions in the myocardial wall
24.	2000	Endothelium-derived hyperplarizing factor nitric oxide play a crucial rde in coronary autoregulation
25.	1999	Role of No and K+ATP channels in adenosine-induced vasodilation on in vivo canine subendocardial arterioles
26.	1999	Role of endothelium-derived hyperpolarizing factors, nitric oxide, and adenosine in both reactive hyperemic responses and coronany autoregulation
27.	1998	In vivo observations of the intramural arterioles and venules in beating canine hearts(共著)
28.	1998	Hypertensive hypertrophic hearts -Endothelium-dependent and -independent vasodilator mechanisms and action of angiotensin-converting enzyme inhibitors on subendocardial arteriolies-
29.	1997	The relationship between cardiac contraction and intramyocardial hemodynamics-New tools for analyzing the coronary venous system-(共著)
30.	1995	Direct invivo observation of subendocardial arteriolar response during reactive hyperemia
31.	1994	Effects of nitroglycerin on diameter and pulsation amplitude of subendocardial arterioles in beating porcine heart
32.	1994	Diameters of subendocardial arterioles and venules during prolonged diastole in canine left ventricles
33.	1993	In vivo observation of subendocardial microvessels of the beating porcine heart using a needle-probe videomicroscope with a CCD camera (共著)
34.	1992	Effect of coronary stenosis on phasic pattern of septal artery in dog(共著)
35.	1992	Phasic characteristics of arterial inflow and venous outflow of right ventricular myocardium in dog(共著)
36.	1992	Atrial contractility effects phasic blood flow velocity of atrial small vessels in the dog. (共著)
37.	1992	Blood velocity patterns in poststenotic regions and velocity waveforms for myocardial inflow associated with coronary artery stenosis in dog. (共著)
38.	2018/07	Endothelium-dependent hyperpolarization-mediatedvasodilatation compensates nitric oxide-mediated endothelial dysfunction during ischemia in diabetes-induced canine coronary collateral microcirculation in vivo
39.	2013/07	Role of Endogenous Hydrogen Peroxide during Angiotensin Type 1 Receptor Blockers Administration in Pacing-induced Metabolic Coronary Vasodilatation in Dogs in Vivo
40.	2013/06	Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.
41.	2013	Visualisation of Intracellular Calcium Concentratio n Change in Tubuloglomerular Feedback In Vivo
42.	2010/12	Erythropoietin enhances hydrogen peroxide-mediated dilatation of canine coronary collateral arterioles during myocardial ischemia in dogs in vivo
43.	2010/07	Clear Correlation of Tetrahydrobiopterin with Nitric Oxide Bioavailability in Continuous Ambulatory Peritoneal Dialysis
44.	2007	Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo
45.	2006/01	Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo
46.	2005/03	Physiomic approach to biomechanics of coronary microcirculation
47.	1996	Effect of NO and K_ATP channel on the size-dependent responses in subendocardial and subepicardial arteries during reactive hyperemia
48.	1996	Endothelium-dependent and-independent vasodilation in subendocardial arterioles of hypertensine canine hearts
49.	1995	Emax and myocardial microcirculation
50.	1995	Mechanics of intramural blood vessels of beating heart
51.	1995	Subendocardial arterioles have larger vasodilatory capacity and pulsation amplitude than subepicardial ones
52.	1993	Decreased mid-to-late diastolic decay of diastolic coronary artery flow velocity in pressure-overloaded left ventricular hypertrophy(共著)
53.	1993	Effect of cardiac contraction on the perforated intramural arteriole and venule in the dog(共著)
54.	1993	Endocardial coronary microcirculation of the beating heart(共著)
55.	1992/06	Effect of coronary stenosis on phasic pattern of septal artery in dogs
56.	1991	Direct effect of nitroglycerin on phasic pattern and transmyocardial distribition of flow during fixed coronary artery stenosis (共著)
57.	1991	Effect of left ventricular hypertrophy secondary to systematic hypertension of left coronary artery flow dynamics (共著)
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■ Presentation

1.	2012/05/25	Preservation of Endothelial GTP Cyclohydrolase I Activity and Improvement of Renal Nitric Oxide Availability Prevent the Development of Diabetic Nephropathy （Poster notice，General）
2.	2012/06/29	Role of Hydrogen Peroxide and Angiotensin Type 1 Receptor Blockers during Acute Myocardial Infarction with Diabetes Mellitus （Poster notice，General）
3.	2010/06/16	Mechanism for the Device roles of Endothelial Nitric Oxide Syntheses System between Conduit and Resistance Arteries in Mice （Poster notice，General）
4.	2010/06/16	Effects of Endogenous Hydrogen Peroxide and Erythropoietin during Acute Coronary Occlusion in Canine Coronary Native Collateral Microcirculation in Vivo （Poster notice，General）
5.	2012/11/07	Angiotensin Type 1 Receptor Blocker Enhances H2O2-induced Coronary Collateral Vasodilatation and Improves Diabetes-induced Microvascular Endothelial Dysfunction and H2O2 Production during Acute Coronary Occlusion in Canine Coronary Native Collateral Microcirculation in vivo （Speech，General）
6.	2012/11/07	Preservation of Endothelial GTP Cyclohydrolase I Activity and Improvement of Renal Nitric Oxide Availability Prevent the Development of Albuminuria in Diabetes （Poster notice，General）
7.	2012/11/07	Distributional Changes of Glomerular Slit Membrane Components and Widening of Inter-foot Process Spaces in Early Diabetic Rats （Poster notice，General）
8.	2013/03/16	Beneficial Effects of Angiotensin Type 1 Receptor Blocker on H2O2-induced Coronary Vasodilatation of Native Coronary Collateral Microcirculation in Dogs in Vivo （Speech，General）
9.	2010/09/26	Cardioprotective Effects of Hydrogen Peroxide after Erythropoietin Administration during Acute Coronary Occlusion in Canine Native Coronary Collateral Microcirculation in Vivo （Poster notice，General）
10.	2010/11/16	Angiotensin Type 1 Receptor Blockers Enhances H2O2-induced Coronary Collateral Vasodilatation and Improves Diabetes Mellitus-induced Microvascular Endothelial Dysfunction in Canine Native Coronary Collateral Microcirculation in Vivo （Poster notice，General）
11.	2010/11/16	Cardioprotective Role of Hydrogen Peroxide and Erythropoietin during Acute Coronary Occlusion in Canine Native Coronary Collateral Microcirculation in Vivo （Poster notice，General）
12.	2008/11/08	Crucial role of hydrogen peroxide as an endogenous EDHF during acute coronary occlusion and injection of erythropoietin in canine coronary native collateral microcirculation in vivo （Speech）
13.	2009/11/14	Cardioprotective effects of hydrogen peroxide and erythropoietin during acute coronary occlusion in canine coronary native collateral microvessels in vivo （Poster notice，General）
14.	2009/06/01	Role of hydrogen peroxide, an endogenous EDHF during coronary occlusion and injection of erythropoietin in canine coronary native collateral microcirculation
15.	2008/02/21	Role of endothelium-derived hyperpolarizing factor as an endogenous hydrogen peroxide in coronary and mesenteric microcirculation （Speech，General）
16.	2007/11/04	Hydrogen peroxide plays a crucial role in coronary microvascular vasodilation with increased oxidative stress in right ventricles of pulmonary hypertensive rats （Speech，General）
17.	2007/11/04	Crucial role of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor(EDHF) during reactive hyperemia in mouse mesenteric microcirculation in vivo （Speech，General）
18.	2007/11/04	Protective role of hydrogen peroxide and erythropoietin during acute coronary occlusion/reperfusion in native coronary collateral circulation in dogs in vivo （Speech，General）
19.	2006/11/12	Crucial role of hydrogen peroxide as an endogenous endothelium-derived hyperpolarizing factor during pacing-induced metabolic dilatation in canine coronary microvessels in vivo
20.	2006/08/27	Role of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor during reactive hyperemia in mouse mesenteric microvessels in vivo
21.	2005/04/24	Estimated nitric oxide production rate in hemodialysis
22.	2005/03/19	Increased GTP-cyclohydrolase I Expression but not Vitamin C Reversed the Accelerated Atherosclerotic Lesion Formation in Apolipoprotein E-deficient Mice Overexpressing eNOS
23.	2005/02/23	Beneficial effects of a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microcirculation
24.	2004/05/24	Exogenous nitric oxide suppresses flow-dependent endothelium-derived nitric oxide production due to depletion of tetrahydrobiopterin （Poster notice）
25.	2022/03/20	In vivo observation of subendocardial and subepicardial coronary microcirculation of the beating canine heart （Speech，Panelist at Symposium/Workshop (Applied)）
26.	2017/03/18	Role of Endogenous H2O2 during Bradykinin-induced Vasodilatation of Canine Subepicardial and Subendocardial Arterioles in Vivo -An Infrared Fluorescence Microscopic Study- （Speech，General）
27.	2016/05/20	Crucial Role of Endogenous H₂O₂ as an Endothelium-derived Hyperpolarizing Factor during Reactive Hyperemia in Canine Coronary Microcirculation in Vivo -An Infrared Fluorescence Microscope Study- （Poster notice，General）
28.	2015/09/25	Diabetes and Glomerular Filtration Barrier （Poster notice，General）
29.	2015/09/25	H2O2-induced coronary collateral arterioles compensates NO-mediated small arteriolar endothelial dysfunction during coronary occlusion in diabetic dogs in vivo （Poster notice，General）
30.	2013/10/24	Investigation for the Mechanisms of Anti-albuminuic Effects of T Type Ca-channel Blocker through Amelioration of eNOS Uncoupling. （Speech，General）
31.	2013/07/05	Role of Endogenous Hydrogen Peroxide during Angiotensin Type 1 Receptor Blockers Administration in Pacing-induced Metabolic Coronary Vasodilatation in Dogs in Vivo （Poster notice，General）
32.	2011/11/14	Important Role of Endogenous Hydrogen Peroxide during Angiotensin Type 1 Receptor Blockers Administration in Pacing-Induced Metabolic Coronary Vasodilatation in Dogs in Vivo （Poster notice，General）
33.	2011/09/22	Role of GTP cyclohydrolase-1 as a novel therapeutic target of diabetic nephropathy. （Poster notice，General）
34.	2008/11/08	Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice （Speech，General）
35.	2008/07	Relation between nitric oxide (NO) and NO-related substances in continuous ambulatory peritoneal dialysis （General）
36.	2007/11/22	Direct Measurement of Nitric Oxide and Tetrahydrobiopterin Levels in Peritoneal Dialysate （Poster notice，General）
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■ Belonging society

1.	2008/04～2016/03	∟ Editorial Board
2.	2019/03～2020/03	∟ Editorial Board
3.	2006～2012/07	∟ Microvascular Reviews and Communications
4.	2014/02～2015/09	∟ 10th World Congress for Microcirculation, Core Scientific Committee