Faculty Information - Junichi Hiratsuka

Present specialized field

Journal

Presentation

Belonging society

（Last updated : 2023-05-31 08:58:49）

Junichi Hiratsuka
Department Kawasaki University of Medical Welfare ,

Position Professor with Special Assignment

■ Present specialized field

Tumor diagnostics and therapeutics, Otorhinolaryngology, Urology

■ Journal

1.	2020/10	Pharmacokinetics of 10B-p-boronophenylalanine (BPA) in the blood and tumors in human patients: A critical review with special reference to tumor-to-blood (T/B) ratios using resected tumor samples
2.	2020/09/30	Long-term outcome of cutaneous melanoma patients treated with boron neutron capture therapy (BNCT)
3.	2020/05	Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer (JHN002): An open-label phase II trial
4.	2020/04	Boron neutron capture therapy for head and neck cancer: Relevance of nuclear-cytoplasmic volume ratio and anti-tumor effect. - A preliminary report
5.	2020/04	Folliculotropic mycosis fungoides treated with electron beam therapy that evolved into fatal, tumor-stage mycosis fungoides and erythroderma with multiple ulcerations
6.	2018	Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses
7.	2017/10	Efficacy of prophylactic irradiation to the contralateral testis for patients with advanced-stage primary testicular lymphoma: an analysis of outcomes at a single institution.
8.	2017/05	Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: an Asian Prostate HDR-BT Consortium.
9.	2017/05	Retrospective analysisi of definitive radiotherapy for neck node metastasis from unknown primary tumor: Japanese Radiation Oncology Study Group study.
10.	2017/01	Neurton Capture Therapy
11.	2016/11	Evaluation of Fluoride-18-Labeled Boronophenylalanine-Positron Emission Tomography Imaging for the Assessment of Boron Neutron Capture Therapy in Patients with Recurrent Head and Neck Squamous Cell Carcinoma.
12.	2016/10	Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions.
13.	2015/08	Fatal carotid blowout syndrome after BNCT for head and neck cancers.
14.	2015/01	Development of a wavelength-separated type scintillator with optical fiber (SOF) dosimeter to compensate for the Cerenkov radiation effect.
15.	2015	Gastric MALT lymphoma treated with the intensity modulated radiation therapy: A cace report.
16.	2014/07	Docetaxel/ TS-1 with Radiation for Unresectable Squamous Cell Carcinoma of the Esophagus - A Phase II Trial
17.	2014/06	BNCT for advanced or recurrent head and neck cancer.
18.	2014/06	Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck
19.	2014/01	Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer.
20.	2014/01	Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery.
21.	2013/09	Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos.
22.	2013/07	Effect of asbestos exposure on differentiation of cytotoxic T lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells.
23.	2013/05	Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck.
24.	2012/07	Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell
25.	2012/05	A Combined Therapy with Docetaxel and Nedaplatin for Relapsed and Metastatic Esophageal Carcinoma
26.	2012/03	Salvage high-dose-rate brachytherapy for local prostate cancer recurrence after radiotherapy - preliminary results.
27.	2012	Asbestos-Induced Cellular andMolecular Alteration of Immunocompetent Cells and Their Relationship with Chronic Inflammation and Carcinogenesis
28.	2012	Review of reduced tumor immunity caused by asbestos exposure to immunocompetent cells such as T and NK cells.
29.	2012	Stereotactic body radiotherapy for lung tumors: Preliminary results from a single institution.
30.	2011/12	Biological evaluation of dopamine analogues containing phenylboronic acid group as new boron carriers
31.	2011/10	A survey of patients with inflammatory skin recurrence corresponding to the area of previous irradiation after postoperative radiotherapy for breast cancer.
32.	2011/10	Asbestos Induces Reduction of Tumor Immunity
33.	2011/10	Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients.
34.	2011/09	Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-2.
35.	2011/08	Locally recurrent prostate cancer after high-dose-rate brachytherapy: the value of diffusion-weighted imaging, dynamic contrast-enhanced MRI, and T2-weighted imaging in localizing tumors.
36.	2010/11	BNCT for advanced or recurrent head and neck cancer.
37.	2009/04	A feasibility study of novel plastic scintillation dosimetry with pulse-counting mode.
38.	2008/01	Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes.
39.	2006/12	Impact of intra-arterial administration of boron compounds on dose–volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors
40.	2006/12	Small Cell Carcinoma of the Prostate: A Case Report of Long-Term Survival
41.	2006/05	First clinical case of boron neutron capture therapy for head and neck malignancies using (18)F-BPA PET
42.	2006/04	Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma byintratumoral injection of the tyrosinase gane
43.	2005/12	Extrapulmonary Small Cell Carcinoma of the Hypopharyx: A Case Report
44.	2005/12	Low-dose total body irradiation in the treatment of advanced non-Hodgkin's lymphoma: a case report of an elderly patient.
45.	2005/07	Radical prostatectomy vs high-dose-rate brachytherapy for prostate cancer: Health related quality-of-life effects
46.	2005/02	Effects of DNA polymerase inhibitory and antitumor activities of lipase-hydrolyzed glycolipid fractions from spinach
47.	2004/12	Evaluation of serum KL-6 as a predictive marker of radiation pneumonitis in patients with breast-conservation therapy.
48.	2004/09	High-dose-rate iridium-192 afterloading therapy combined with external beam radiotherapy for T1c-T3bN0M0 prostate cancer.(共著)
49.	2004/09	Observation of microvasculatures in athymic nude rat transplanted tumor using synchrotron radiation microangiography system.
50.	2004/07	Clinical results of combined treatment conformal high-dose-rate iridium-192 brachytherapy and external beam radiotherapy using staging lymphadenectomy for localized prostate cancer.
51.	2004/06	Primary central nervous system lymphoma in Japan 1995-1999: changes from the preceding 10 years.
52.	2004/04	Superselective intra-arterial and systemic chemoradiotherapy for advanced head and neck cancers
53.	2003/09	Boron neutron capture therapy (BNCT) for malignant melanoma with special reference to absorbed doses to the normal skin and tumor.
54.	2003/01	Is whole-brain irradiation necessary for primary central nervous system lymphoma? Patterns of recurrence after partial-brain irradiation
55.	2002	Particiaption of Fas-mediated apoptotic pathway in KB, ahuman head and neck squamous cell carcinoma cell line, after irradiation.
56.	2002	Participation of Fas-mediated apoptotic pathway in KB, a human head and neck squamous cell carcinoma cell line, after irradiation
57.	2001/11	Anti-HER2-antibody enhances irradiation-induced growth inhibition in head and neck carcinoma.
58.	2001	Anti-HER2-antibody enhances irradiation-induced growth inhibition in head and neck carcinoma.(共著)
59.	2001	BNCT for melanotic/amelanofic melanoma transplanted into animal brain(共著)
60.	2000	Biodistribution of Boron Concentration on Melanoma-bearing Hamsters after Administration of p-, m-, o-Boronophenylalanine. (共著)
61.	2000	Expression of cell cycle regulator genes in KB, a human squamous cell carcinoma cell line, after irradiation. (共著)
62.	2000	Gadolinium neutron-capture therapy using novel gadopentetic acid-chitosan complex nanoparticles : in vivo growth suppression of experimental melanoma solid tumor. (共著)
63.	2000	High dose rate interstitial brachytherapy with external beam irradiation For localized prostate cancer : Preliminary results. (共著)
64.	2000	High dose rate microselectron mould ratiotherapy of a widespread superficial oral cancer (共著)
65.	2000	Interstitial brachytherapy for recurrent breast cancer using a high dose rate Ir-192 remote afterloading system: a report of two cases.
66.	2000	Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene. (共著)
67.	2000	Tyrosinase Mini-Gene Injection into Amelanotic Melanoma Tumor Enhances the Killing Effect of BNCT. (共著)
68.	1999	High dose rate Microselection mould radiotherapy of a widespread superficial oral cancer
69.	1999	Pharmacokinetics of 10B-p-boronophenylalanine in tumours, skin and blood of melanoma patient : a study of boron capture therapy for malignant melanoma. (共著)
70.	1999	Selective uptake of p-boronophenylalanine increases by trausfecting tyrosinese gene to amelanotic melanoma cells.
71.	1998	A Case of Eosinophilic Granuloma of the Soft Tissue Treated with Radiation Therapy
72.	1998	A JASTRO STUDY GROUP REPORT"A RANDOMIZED PHASE(]G0003[) TRIAL OF HYPERTHERMIA IN COMBINATION WITH RADIOTHERAPY FOR SUPERFICIAL TUMORS"
73.	1998	Enhanced melanogenesise induced by trrosinase gene-transfer increases boron-uptake and killing effect of boron neutror capture therapy for amelanotic melanoma. (共著)
74.	1998	In vivo suppression of tumor growth by gadolinium-neutron capture therapy using novel gadopentetate-loaded chitosan nanoparticles. (共著)
75.	1998	Intra-tumor injection of tyrosinase mini-gene euhances the killing effect of BNCT for amelanotic melanoma.(共著)
76.	1998	Radiotherapy for Bone Metastases of Malignant Pheochromocytoma
77.	1997	A Retrospective Study of Results of Conservative Therapy for Breast Cancer in Japan
78.	1997	Capture of p-boronophenylalanine in malignant melanoma cells by complex formation with melanin monomers, DOPA, DHI and DHICA.
79.	1997	Enhancement of killing Effect on Amelanotic Melanoma by BNCT with Tyrosinase-gene Transfer.
80.	1997	Tumor-killing effect of BNCT after administration of o^-, m^- and p^- boronophenylalanine.
81.	1996	Human Melamoma Treated by Boron Neutron Capture therapy : Comparison of the Clinical Response with the Predicted Response.
82.	1996	Retrospective Study of Interstitial Radiotherapy for cancer of the Tongue.
83.	1996	Retrospective study of results of interstitial radiotherapy for cancer of the tongne
84.	1995	¹⁰B₁-BPA Administration to Melanoma Patients for Neutron Capture Therapy((]G0002[))-from Nov.1991 to Dec., 1994-(共著)
85.	1995	Therapeutic Results of Intraarterial Chemotherapy and Concurrent radiation for Invasive Bladder Cancer.
86.	1995	Thermal neutron distribution in nodular melanoma for BNCT……Data analysis of pre-clinical study and clinical trial.
87.	1994	Boron Neutron Capture Therapy of Malignaut Melanoma Using ¹0B-Paraboronophenylalanine with Special reference to Evaluation of Rediation Dose and Damage to the Normal Skin (共著)
88.	1994	Radiotherapeutic management of isolated loco-regional recurrence of breast cancer after mastectomy.
89.	1994	Results in MRI estimation of direct invasion of ovarian cancer.
90.	1994	Significant Increases in Serum CA125 and CA19-9 Following Torsion from an Adenofibroma of the Ovary : A Case Report (共著)
91.	1993	Establishment of Optimal thermal Neutron Capture Therapy for 5 Types of Human Maligrant Melanoma.
92.	1993	Relation between the Local Effect of Thermoradiotherapy and the Prognosis for Recurrent Lung Cancers.
93.	1993	Results of Mastectomy and Postoperative Regional Nodal Irradiation in the Management of Breast Cancer-Indications and effectiveness today and in the future-
94.	1992	A Case f Transitional Cell Carcinoma with ystic Degeneration Following Thermoradiotherapy
95.	1991	Clinical Response and Theoretical Response on Human Melanoma Treated by Neutron Capture Therapy
96.	1991	Radiotherapy of Bile Duct Carcinoma Using Intracatheter ¹⁹⁸Au Grains
97.	1991	The Relative Biological Effectiveness of ¹⁰B-Neutron Capture Therapy for Early Skin Reaction in the Hamster
98.	1990/06	Boron neutron capture therapy for head and neck cancer: Relevance of nuclear-cytoplasmic volume ratio and anti-tumor effect. - A preliminary report -
99.	1990	Clinical Results of Thermoradiotherapy for Recurrent Lung Cancer
100.	1989	RBEs of Thermal Neutron Capture Therapy and ¹⁰B(n, α)⁷Li Reaction on Melanoma-Bearing Hamsters
101.	1989	Results of Local Effect on Recurrent Lung Cancers Treated with combined Radiotherapy and Hyperthermia
102.	1989	Treatment of Malignant Melanoma by Single Thermal Neutron Capture Therapy with Melanoma-Seeking ¹⁰B-Compound
103.	1988	Roentgenographic Evaluation of Three Cases of Hodgkin's Disease
104.	1987	Effectiveness of Radiation Therapy for Metastatic Bone Tumors
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■ Presentation

1.	2018/01/27	BNCT for vulvar melanoma and extramammary Paget's disease of the genital regions. （Speech，General）
2.	2017/09/09	Clinical Trials of BNCT for melanoma and H&N tumor in Japan-Contribution of BPA- （Speech，Panelist at Symposium/Workshop (Appointed)）
3.	2017/08/10	Experience of preclinical and Clinical Trial of BNCT in Japan. （Speech，Keynote）
4.	2017/07/10	Clinical Trial of BNCT in Japan-Contribution of BPA. （Speech，Keynote）
5.	2016/11/26	Elective neck irradiation of 40 Gy/20 fr is sufficient in the treatment of head and neck cancers （Poster notice，General）
6.	2012/12/01	Tumor response of Head and Neck Cancer with huge mass after BNCT （Speech，General）
7.	2012/07/19	Boron Neutron Capture Therapy for Advanced Head and Neck Tumor in Japan （Speech，Panelist at Symposium/Workshop (Other)）
8.	2011/12/04	BNCT for Skin Cancer and Advanced Head and Neck Cancer in Japan （Speech，Special/Invited Lecture）
9.	2010/06/10	Clinical Trial of Boron Neutron Capture Therapy for Cutaneous Melanoma Using 10B-para-boronophenylalanine （Speech，General）
10.	2008/09/10	A phase study of docetaxel /S-1 with radiation for esophageal cancer patients
11.	2007/10/12	Cｌｉｎｉｃａｌ　Ｔｒｉａｌｓ　ｉｎ　Ｊａｐａｎ（Speech，Special/Invited Lecture）
12.	2007/09	Health-related Quality of Life in Patients with Localized Prostate Cancer Received High-Dose-Rate Brachytherapy: A Time-Course Analysis （Poster notice，General）
13.	2006/10/09	Development of a real-time thermal neutron monitor and its clinical application （Speech，General）
14.	2006/10/09	Estimation of Intratumor Boron Concentration of Boron Neutron Capture Therapy for Head and Neck Tumors Using 18FBPA-PET Image （Speech，General）
15.	2006/10/09	First clinical trial of boron neutron capture therapy for thyroid cancer. （Speech，General）
16.	2006/10/09	Gadolinium-loaded Chitosan Nanoparticles for Cancer Neutron-capture Therapy: Pharmaceutical Characteristics and In Vitro Antitumor Effect. （Speech，General）
17.	2006/10/09	Using BPA alone for boron neutron caprure therapu of recurerent head and neck malignancies （Speech，General）
18.	2004/10/29	Superselective intra-arterial and systemic chemoradiotherapy for advanced head and neck cancers （Speech，General）
19.	2004/10/14	Clinical Trial of BNCT for the Head and Neck Tumor. （Speech，General）
20.	2004/10/11	Enhanced Killing Effect of Boron Neutron Capture Therapy for Amelanotic Melanoma by Direct Intra-tumor Injection of Tyrosinase Gene （Speech，General）
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■ Belonging society

1.	2004/04～	Japanese Society of Neutron Capture Therapy
2.		International Society of Neutron Capture Therapy