Faculty Information - Hiroyuki Kadoya

Present specialized field

Journal

Presentation

（Last updated : 2026-05-14 15:00:01）

Hiroyuki Kadoya
Department Kawasaki Medical School Kawasaki Medical School, Department of General Geriatric Medicine,

Position Associate Professor

■ Present specialized field

Nephrology

■ Journal

1.	2026/04	Finerenone Improves Albuminuria via MR-TRPC Signaling in Diabetic Kidney Disease
2.	2026/01	Survey of exit-site management practices of peritoneal dialysis in Japan
3.	2025/12/17	The Antibiotic effect of Silver CAPD Catheter on Peritoneal Dialysis-related infections (ASCA-PD) study: a multicenter randomized open-label trial protocol.
4.	2025/04/30	A case of advanced renal cell carcinoma with concomitant development of multiple endocrine neoplasia type 1 that affected treatment progress with immunotherapy
5.	2024/11/02	ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice
6.	2024/11	Effects of Beraprost on Intestinal Microcirculation and Barrier Function in a Mouse Model of Renal Failure. inpress
7.	2024/09	Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging
8.	2024/09	Treatment of chronic kidney disease in older populations
9.	2024/08	Never give up! A case of weaning from 40 years of hemodialysis
10.	2024/04/10	Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney
11.	2023/12/19	IL-1β may be an indicator of peritoneal deterioration after healing of peritoneal dialysis-associated peritonitis
12.	2023/10/01	Insights into the regulation of glomerular filtration rate by the Keap1-Nrf2 pathway
13.	2023/09	Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis
14.	2022/03/23	A case of pleuroperitoneal communication during long-term steroid therapy for dermatomyositis
15.	2021/11	Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function
16.	2021/08	A rare case of amyloid light-chain amyloidosis with bilateral perirenal hematoma shortly after initiation of peritoneal dialysis.
17.	2021/06/04	Dual disruption of eNOS and ApoE gene accelerates kidney fibrosis and senescence after injury
18.	2021/06	Renal cell carcinoma sharply captured by imaging technology at an early stage in a hemodialysis patient: Usefulness of noninvasive monochrome superb microvascular imaging
19.	2021/05/24	Serial intravital imaging captures dynamic and functional endothelial remodeling with single-cell resolution
20.	2021/05/11	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
21.	2021/01/20	Roxadustat and thyroid-stimulating hormone suppression.
22.	2020/12/24	Drastic change in protein intake may cause a rapid decline of residual renal function after initiation of peritoneal dialysis.
23.	2020/11/01	Non-purine selective xanthine oxidase inhibitor ameliorates glomerular endothelial injury in InsAkita diabetic mice.
24.	2020/10/02	Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis
25.	2020/05/01	Klotho is a novel therapeutic target in peritoneal fibrosis via Wnt signaling inhibition.
26.	2019/01	Aldosterone induces albuminuria via matrix metalloproteinase–dependent damage of the endothelial glycocalyx
27.	2018/01	Advances in Renal Cell Imaging
28.	2017/05/02	Colchicine attenuates renal fibrosis in a murine unilateral ureteral obstruction model.
29.	2017/03	Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging.
30.	2016/10	Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice.
31.	2016/08	A Case of Copper Deficiency-Induced Pancytopenia With Maintenance Hemodialysis Outpatient Treated With Polaprezinc.
32.	2016/02	Prevalence of gastroesophageal reflux disease symptoms and effects of esomeprazole on the quality of life related to reflux and dyspepsia in patients on maintenance hemodialysis.
33.	2015/09	Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice.
34.	2015/08	Deficiency of endothelial nitric oxide signaling pathway exacerbates peritoneal fibrosis in mice.
35.	2015/06/05	Combination Irbesartan/Amlodipine versus Irbesartan/Cilnidipine for Attenuation of Albuminuria in Rats with Streptozotocin-Induced Diabetic Nephropathy.
36.	2015/05	Combination Irbesartan/Amlodipine versus Irbesartan/Cilnidipine for Attenuation of Albuminuria in Rats with Streptozotocin-Induced Diabetic Nephropathy
37.	2014	Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats.
38.	2013/04	Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status.
39.	2012/05	A case of anti-GBM glomerulonephritis and membranous nephropathy in a patient with primary biliary cirrhosis
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■ Presentation

1.	2026/03/29	Survey of exit-site management practices of peritoneal dialysis in Japan （Poster notice，General）
2.	2024/09/15	Endothelial Dysfunction Fuels Progression from Acute to Chronic Kidney Disease through Macrophage-Mediated β-Catenin Activation （Poster notice，General）
3.	2024/09/15	Impaired Glomerular Epithelial Cell sGC Activation Promotes Glomer- Significance of Glomerular Epithelial Cell sGC Activation via eNOS-NO Pathway in Diabetic Kidney Disease （Poster notice，General）
4.	2024/09/15	SGLT2 Inhibition suppresses residual nephron glomerular hyperfiltration in Non-Diabetic Chronic Kidney Disease （Poster notice，General）
5.	2024/09/14	Elucidation of glomerular hemodynamic changes by mineralocorticoid receptor blocker esaxerenone in diabetic kidney disease （Poster notice，General）
6.	2022/10/15	Endothelial dysfunction exacerbates kidney dysfunction in ageing kidney via activation of inflammasome （Poster notice，General）
7.	2022/10/15	eNOS-NO pathway regulates inflammasome activation in diabetic mice via modulation of CEBP translocation （Poster notice，General）
8.	2022/10/15	eNOS/NO signaling regulates renal interstitial fibrosis by increasing cytoplasmic beta-catenin degradation （Poster notice，General）
9.	2022/10/15	Regulatory mechanism of glomerular filtration rate by the Keap1/Nrf2 pathway （Poster notice，General）
10.	2021/02/28	Evaluation of glomerular hemodynamic changes by SGLT2 inhibitor and ARB in type 2 diabetic rats using in vivo imaging （Speech，General）
11.	2020/10/19	Effect of Zinc Deficiency on CKD Progression and Effect Modification by Hypoalbuminemia. （Poster notice，General）
12.	2020/10/19	eNOS/NO Signaling Attenuates Progression of Age-Related Kidney Diseases via Suppression of Inflammasome. （Poster notice，General）
13.	2020/10/02	DEFICIENT OF ENOS/NO PATHWAY PROMOTES AKI TO CKD TRANSITION AFTER ISCHEMIC REPERFUSION （Poster notice，General）
14.	2020/10/02	ENOS/NO SIGNALLING ATTENUATES GLOMERULAR INJURY IN DIABETIC MICE VIA SUPPRESSION OF INFLAMMASOME ACTIVATION （Poster notice，General）
15.	2020/10/02	EVALUATION OF THE MECHANISM OF GLOMERULAR ARTERIOLE CHANGES BY SGLT2 INHIBITION IN TYPE 2 DIABETIC RATS （Poster notice，General）
16.	2020/10/02	Inflammasome Activation Plays a Key Role on the Progression of Peritoneal Fibrosis in Mice （Poster notice，General）
17.	2020/06/07	Effects of sodium–glucose cotransporter 2 inhibitor, canagliflozin on glomerular hyperfiltration and oxidative stress in mice with type 2 diabetes （Speech，General）
18.	2020/06/07	EVALUATION OF GLOMERULAR HEMODYNAMIC CHANGES BY SGLT2 INHIBITION IN TYPE 2 DIABETIC RATS USING IN VIVO IMAGING TECHNIQUES （Speech，General）
19.	2020/02/15	Zinc deficiency is a risk factor for chronic kidney disease progression （Speech，General）
20.	2019/11/09	Endothelial Nitric Oxide Synthase/Nitric Oxide Pathway Underlies the Mechanisms of AKI to CKD Transition via Prolonged Activation of the Wnt/β-Catenin Pathway （Poster notice，General）
21.	2019/11/09	Implication of Inflammasome Activation in the Progression of Peritoneal Fibrosis in Mice （Poster notice，General）
22.	2019/11/08	Clarification of the Mechanism of Acute GFR Change by SGLT2 Inhibition with In Vivo Imaging Technique （Poster notice，General）
23.	2019/09/07	A Case of rapid decline of residual renal function after initiation of initiation of peritoneal dialysis. （Poster notice，General）
24.	2019/09/05	Inframmasome activation plays a key role in chronic inflammation and development of peri-toneal fibrosis （Poster notice，General）
25.	2019/06/13	Implication of inflammasome activation in the development of peritoneal fibrosis. （Poster notice，General）
26.	2018/10/25	Endothelial Dysfunction Exacerbates Renal Tubular Cell Injury Through Inflammasome Activation in a Hypertensive Mouse Model （Poster notice，General）
27.	2018/10/25	Uremic Toxin Decreases Intestinal Defense Peptides and Barrier Functions in Chronic Renal Failure Mice （Poster notice，General）
28.	2018/02/22	A case of copper deficiency-induced pancytopenia with maintenance hemodialysis outpatient treated with polaprezinc . （Poster notice，General）
29.	2016/09/26	Hypertension Promotes Islet Morphological Changes with Vascular Injury on Prediabetic Status in SHR-SP Rats. （Poster notice，General）
30.	2015/11/05	Possible Implication of Xanthine Oxidase Activation on the Pathogenesis Diabetic Nephropathy. （Poster notice，General）
31.	2015/09/28	Excess Aldosterone is a Critical Danger Signal for Inflammasome Activation in the Development of Renal Fibrosis in Mice. （Poster notice，General）
32.	2015/09/25	Possible implication of xanthine oxidase activation on the pathogenesis diabetic nephropathy. （Poster notice，General）
33.	2015/09/25	Visualization of in vivo renin activity and its application to study the pathogenetic mechanisms of diabetic nephropathy （Poster notice，General）
34.	2015/03/16	Low-Dose Colchicine Treatment Attenuates Renal Fibrosis in Mice Unilateral Ureteral Obstruction. （Poster notice，General）
35.	2015/02/28	Protective role of klotho protein on peritoneal membrane via suppression of wnt/B-catenin signaling in mice. （Speech，General）
36.	2014/11/15	Klotho Overexpression Attenuates Peritoneal Fibrosis via Suppression of Wnt/B-Catenin Signaling Pathway in Mice （Speech，General）
37.	2014/11/14	Enhancement of Wnt/B-Catenin Signaling Promotes Renal Fibrosis by Inducing Cell Cycle Arrest at the G2/M Phase in Tubular Epithelial Cells （Poster notice，General）
38.	2014/10/17	Development of a Novel In Vivo-Imaging Technique to Detect Renin-Activity in an Attempt to Elucidate Reno-Protective Effects of Calcium-Channel Blocker （Poster notice，General）
39.	2014/10/17	Molecular Mechanisms of Aldosterone-Induced Renal Interstitial Fibrosis and Ameliorative Effects of Mineralocorticoid Receptor Antagonist （Speech，General）
40.	2014/06/01	Activation of eNOS Signaling Attenuates Renal Fibrosis in Mice by The Increase of Beta Catenin Degradation. （Poster notice，General）
41.	2014/05/15	Implication of Inflammasome Activation in The Development of Renal Interstitial Inflammation and Fibrosis Induced by Aldosterone. （Speech，General）
42.	2014/02/22	Aldosterone induces renal tubulointerstitial inflammation and fibrosis via activation of inflammasome in infltrating macrophages. （Poster notice，General）
43.	2013/12/17	Implication of inflammasome activation in the development of renal interstitial inflammation and fibrosis induced by aldosterone. （Speech，General）
44.	2013/11/09	Comparison of Combination Therapy with Irbesartan/Amlodipine and Irbesartan/Cilnidipine for Attenuation of Albuminuria in Rats with Streptozotocin-Induced Diabetic Nephropathy. （Poster notice，General）
45.	2013/11/07	Implication of Inflammasome Activation via Mitochondrial Reactive Oxygen Species in the Development of Renal Interstitial Fibrosis Induced by Aldosterone. （Poster notice，General）
46.	2013/11/07	T Type Ca-Channel Blocker Exerts Anti-Albuminuic Effect through Amelioration of eNOS Uncoupling in Hypertensive Kidney Disease Model. （Poster notice，General）
47.	2013/10/26	Molecular Mechanism of Mineralocorticoid Receptor Antagonist on Suppressive Effects of Inflammasome Activation by Aldosterone. （Poster notice，General）
48.	2013/10/24	Comparison of Combination Therapy with Irbesartan/Amlodipine and Irbesartan/Cilnidipine for Attenuation of Albuminuria in Rats with Streptozotocin Induced Diabetic Nephropathy. （Poster notice，General）
49.	2013/10/24	Investigation for the Mechanisms of Anti-albuminuic Effects of T Type Ca-channel Blocker through Amelioration of eNOS Uncoupling. （Speech，General）
50.	2013/10/24	Islet Microangiopathy in Hypertensive Rats and the Protective Effects of ARB on the Islet Morphology. （Speech，General）
51.	2013/06/02	Implications of Inflammasome-Activation in Macrophage on the Development of Renal Interstitial Inflammation and Fibrosis in Mice. （Poster notice，General）
52.	2013/06/01	Development of Novel Technique to Visualize in vivo Renin Activity and Analysis of Reno-Protective Actions of Renin Inhibitor in Diabetic Nephropathy. （Poster notice，General）
53.	2013/06/01	Rosuvastatin Maintain Glomerular Endothelial Surface layer Through Nrf2 Activation in Mouse Diabetic Nephropathy. （Poster notice，General）
54.	2013/04/28	Aldosterone induces renal interstitial inflammation and fibrosis by activation of inflammasome via mitochondrial reactive oxygen species in macrophage. （Poster notice，General）
55.	2013/04/21	Implication of inflammasome in the development of renal interstitial fibrosis induced by aldsoterone （Poster notice，General）
56.	2012/11/06	Spironolactone Suppresses the Inflammasome in Aldosterone Induced Renal Dysfunction via Blood Pressure Independent Pathway. （Poster notice，General）
57.	2012/11/02	Erythropoietin Activates NAD(P)H Oxidase via Erythropoietin Receptor and Beta Common Receptor on Vascular Endothelial Cells. （Poster notice，General）
58.	2012/11/02	Klotho Attenuates Inflammation of Adipose Tissue and Development of Insulin Resistance in High-Fat Induced Obese Mice. （Poster notice，General）
59.	2012/11/02	Stimulation of Soluble Guanylate Cyclase Attenuates Epithelial-Mesenchymal Transition of the Peritoneal Membrane and Prevent the Development of Peritoneal Fibrosis. （Speech，General）
60.	2012/07/20	eNOS-sGC pathway suppresses renal fibrosis via interruption of the Wnt-beta-catenin pathway in UUO mice. （Poster notice，General）
61.	2012/05/25	Endothelial Dysfunction promotes the Transition from Compensatory Renal Hypertrophy to Kidney Injury after Unilateral Neophrectomy in Mice. （Poster notice）
62.	2012/05/25	Preservation of Endothelial GTP Cyclohydrolase I Activity and Improvement of Renal Nitric Oxide Availability Prevent the Development of Diabetic Nephropathy （Poster notice，General）
63.	2011/11/12	Low-Dose Erythropoietin Increases Superoxide Production in Normal Rat Aorta and Endothelial Cells （Poster notice，General）
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