Faculty Information - Akira Hanashima

（Last updated : 2025-12-03 18:12:18）

Akira Hanashima
Department Kawasaki Medical School Kawasaki Medical School, Department of Physiology 1,

Position Assistant Professor

■ Present specialized field

Biomedical engineering, Animal physiological chemistry, physiology and behavioral biology, Evolutionary biology, Biogeosciences, Physiology

■ Journal

1.	2025/11	CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress.
2.	2025/07/09	Cartilaginous fish and mammalian connectin evolved independently from an ancestral bony fish-like structure
3.	2025/04/27	The Ancestor and Evolution of the Giant Muscle Protein Connectin/Titin
4.	2024/06/14	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.
5.	2024/04/21	Comparative analysis of ventricular stiffness across species.
6.	2024/03/11	Optical development in the murine eye lens of accelerated senescence-prone SAMP8 and senescence-resistant SAMR1 strains
7.	2022/11/04	Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon
8.	2022/08/20	Oxygen environment and cardiac regeneration
9.	2022/05/20	Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
10.	2019/10	Transcripts of the nebulin gene from Ciona heart and their implications for the evolution of nebulin family genes.
11.	2019/04	A great legacy of muscle research and education from Dr. Sumiko Kimura
12.	2018/12	Obituary: Sumiko Kimura 1947-2018
13.	2018/05	Turtle spongious ventricles exhibit more compliant diastolic property and possess larger elastic regions of connectin in comparison to rat compact left ventricles
14.	2017/06	Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.
15.	2017/01	Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle
16.	2015/12	Left ventricular mechanics and myocardial calcium dynamics in short-term and long-term hyperthyroid mice
17.	2014	Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1.
18.	2014	Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors.
19.	2013	Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.
20.	2012	Actin capping proteins, CapZ (beta-actinin) and tropomodulin in amphioxus striated muscle.
21.	2012	Genomic- and protein-based approaches for connectin(titin) identification in the ascidian Ciona intestinalis.
22.	2011	Amphioxus Connectin Exhibits Merged Structure as Invertebrate Connectin in I-Band Region and Vertebrate Connectin in A-Band Region.
23.	2010	Isolation of Nebulin from Rabbit Skeletal Muscle and Its Interaction with Actin.
24.	2009	Characterization of amphioxus nebulin and its similarity to human nebulin.
25.	2009	Structure of the amphioxus nebulin gene and evolution of the nebulin family genes.
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■ Presentation

1.	2025/09/11	Evolutionary convergence of the heart in Mammals and Cephalopods: shortening of connectin/titin in ventricular myocardium with increased activity （Poster notice，General）
2.	2025/09/05	Integrated analysis of squid heart structure and elastic protein connectin （Poster notice，General）
3.	2025/03/19	Evolutionary and physiological analysis of molluscan hearts based on the muscle elastic protein connectin （Speech，General）
4.	2022/09/10	Evolution of an unique blood pump system in the jawless lamprey （Speech，General）
5.	2022/03/18	Elucidation of mammalian heart evolution by multiscale analysis of the lobster heart （Poster notice，General）
6.	2019/03/30	Comparison of cardiomyocyte kinetics of rat left ventricle and turtle ventricle （Poster notice，General）
7.	2019/03/30	Evolutional relationship between hearts and elastic protein connectins （Poster notice，General）
8.	2019/03/29	Nuclear connectin novex-3 is essential for proliferation of hypoxic fetal cardiomyocytes （Poster notice，General）
9.	2018/06/19	Comparative study of tensile properties of ventricular cardiomyocytes of rat and turtle （Poster notice，General）
10.	2018/03/30	Comparison of extensibility of rat compact left ventricle and turtle spongious ventricle （Poster notice，General）
11.	2018/03/29	Elastic structures of connectin shortened in coronary circulation hearts （Poster notice，General）
12.	2016/11/17	Relationship between heart evolution and elastic structure of connectin in vertebrate （Poster notice，General）
13.	2016/04/28	Elastic structure of connectin in the hearts with coronary and non-coronary circulation （Poster notice，General）
14.	2016/04/27	Fam64a is essential for low oxygen-induced fetal cardiomyocyte proliferation （Poster notice，General）
15.	2016/03/22	Elastic structures of cardiac connectin in the vertebrate hearts with coronary and sinusoidal circulation （Poster notice，General）
16.	2016/03/22	Identification of critical molecule mediating oxygen-dependent cell cycle arrest of cardiomyocytes around birth in mice （Poster notice，General）
17.	2015/02	Proteins in striated muscles that transcribed from the contiguous region of connectin gene. （Poster notice，General）
18.	2014/07	The analysis of novel proteins in striated muscle that are transcribed from connectin upstream genes. （Poster notice，General）
19.	2014/02	Localization and binding partners of SESTD1 in skeletal muscles. （Poster notice，General）
20.	2012/04	Genomic- and Protein-Based Approaches for Connectin-Like Protein Identification in Amphioxus and Ascidian. （Speech，Special/Invited Lecture）
21.	2010/09	Amphioxus striated muscle has beta-actinin and tropomodulin. （Poster notice，General）
22.	2010/09	The connectin-like protein gene of amphioxus striated muscle. （Poster notice，General）
23.	2009/08	Sequence of the connectin-like giant proteins in invertebrate muscle. （Poster notice，General）
24.	2009/07	C-terminus of nebulin binds to alpha-actinin. （Poster notice，General）
25.	2008/06	Sequence of the C-terminal region of amphioxus nebulin and its binding proteins. （Poster notice，General）
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