Faculty Information - Akira Yamauchi

Current specialization

Publications

Journal Articles

Presentations

Professional Organizations

（Last updated : 2025-09-12 20:53:04）

Akira Yamauchi
Department Kawasaki Medical School Kawasaki Medical School, Department of Biochemistry,

Position Professor

■ Current specialization

Medical biochemistry, Immunology, Cell biology, Tumor biology, Pathological biochemistry, Bacteriology, Virology, Connective tissue disease and allergy, Digestive surgery (Key Word：Host Defense, NADPH oxidase, cellular chemotaxis, Visualization of Cell Function, Cancer metastasis, Flavor and Fragrance)

■ Publications

2010

Functions of the phagocyte NADPH oxidase and Chronic Granulomatous Disease., Neutrophils: Lifespan, Functions and Roles in Disease.

■ Journal Articles

1.	2025/09/04	Comparison of the Anticancer Effects of a Complementary Peptide for Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3) With Conventional Anticancer Drugs in the Treatment of Oral Squamous Cell Carcinoma: A Pilot Study
2.	2025/07/30	Establishment of a method to evaluate the dynamics of highly chemotactic THP-1 cells during differentiation into monocyte-M1 macrophage-like cells
3.	2025/03/11	NADPH oxidase subunit p22^phox: A marker of oxidase-dependent oxidative stress and target for stress suppression in nonphagocytic cells
4.	2025/01/21	An S100A8/A9 Neutralizing Antibody Potently Ameliorates Contact Hypersensitivity and Atopic Dermatitis Symptoms.
5.	2024/12	Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cells.
6.	2024/05/28	Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis
7.	2024/05/09	Anti-fatigue activity of methyl dihydrojasmonate and linalool in a rat model evaluated by a novel index for neuro-immune and oxidative stress interactions
8.	2024/03/26	Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface
9.	2023/12	DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database
10.	2023/11	DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer
11.	2023/04/04	Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2.
12.	2023/02/23	LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells.
13.	2023/01/06	Characterization of missense mutations in the NADPH oxidase partner p22^phox in the A22° subtype of chronic granulomatous disease.
14.	2022/12/19	Identification of anti-SARS-CoV-2 agents based on flavor/fragrance compositions that inhibit the interaction between the virus receptor binding domain and human angiotensin converting enzyme 2.
15.	2022/11/15	Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC).
16.	2022	Sorafenib-induced apoptosis in colonic neuroendocrine carcinoma cells
17.	2022/09/30	Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation.
18.	2022/09/29	Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay
19.	2022/09/13	Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22^phox by thiol modification.
20.	2022/09/07	Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells.
21.	2022/06/16	DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer.
22.	2022/02	Fine definition of the epitopes on the human gp91^phox/NOX2 for the monoclonal antibodies CL-5 and 48
23.	2022/01/11	The downregulation of NADPH oxidase Nox4 during hypoxia in hemangioendothelioma cells: a possible role of p22^phox on Nox4 protein stability.
24.	2022/01/08	Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner
25.	2021/03/26	The efficient detection of membrane protein with immunoblotting: lessons from cold-temperature denaturation
26.	2020/10/24	Nanoparticle-mediated delivery of 2-deoxy-D-glucose induces antitumor immunity and cytotoxicity in liver tumors in mice.
27.	2020/09/28	Constitutive activity of NADPH oxidase 1 (Nox1) that promotes its own activity suppresses the colon epithelial cell migration
28.	2020	Synthesis of 4-aroyl-5-arylpyrazoles and 4-aroyl-3-arylpyrazoles via the reaction of enaminodiketones with substituted hydrazines
29.	2020/09	Inhibitory effect of eicosapentaenoic acid on the migration of the esophageal squamous cell carcinoma cell line TE-1
30.	2020/08/15	The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells
31.	2020/07/02	The NADPH oxidase NOX4 promotes the directed migration of endothelial cells by stabilizing vascular endothelial growth factor receptor 2 protein
32.	2020/05/17	Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility.
33.	2020/05/16	Retinoic acid dramatically enhanced cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils
34.	2019/08	Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts.
35.	2019/07	Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.
36.	2019/07	Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue.
37.	2019/06	Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.
38.	2018/11	Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers
39.	2018/10	exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.
40.	2019/06	Neuroplastin-b mediates S100A8/A9-induced lung cancer disseminative progression.
41.	2019/03	DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.
42.	2019/01	Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice.
43.	2018/11	Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.
44.	2018/07	Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms.
45.	2018/04	b-1,3-Galactosyl-O-Glycosyl-Glycoprotein b-1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.
46.	2018/04	Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit.
47.	2018/01	DKK3 Overexpression Increases Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.
48.	2017/03	Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device
49.	2016/10	Homodimerisation of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-Labile Disulfide is critical for Hyaluronan Binding in Lymphatic Endothelium.
50.	2016/06	Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells.
51.	2016/08	MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kB and ROS formation upon ligand binding.
52.	2015/01	Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an anti-human CCR4 mAb (KM2760).
53.	2014/02	Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients.
54.	2013/10	Human skin melanocyte migration towards stromal cell-derived factor-1a demonstrated by optical real-time cell mobility assay: Modulation of their chemotactic ability by a-melanocyte stimulating hormone
55.	2013/07	Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells
56.	2011/06	A highly sensitive chemiluminescence assay for superoxide detection and chronic granulomatous disease diagnosis
57.	2008/12	Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue.
58.	2007/03	Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device - TAXIScan
59.	2007/12	Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins
60.	2005/01	Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo - Role of the C-terminal polybasic domain
61.	2005/04	Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways
62.	2004/11	Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles
63.	2002/11	Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: Preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions
64.	2001/03	Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b(558), to the extracellular peptide portion of primate gp91(phox)
65.	2000/12	Phorbol ester-potentiated liposomal transfection to monocytic PLB-985 cells
66.	2000/03	Eosinophil-specific regulation of gp91(phox) gene expression by transcription factors GATA-1 and GATA-2
67.	1998/08	An X-linked variant chronic granulomatous disease due to failure in PU.1 binding
68.	2023/03/23	Tumor suppressing effects of complementary peptide targeting DKK3 in head and neck squamous cell carcinoma.
69.	2022/01/19	Activity Report of Industry-Academia Collaboration and Intellectual Property Management Section, Kawasaki Medical School - the middle of 2020 fiscal year to the middle of 2021 -
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■ Presentations

1.	2023/09/23	Discovery of Pyrazole-based Anti-cancer Compounds via Cell-based Drug Discovery （Poster notice，General）
2.	2023/09/01	Cellular Dynamics Analysis and Drug Discovery Targeting Cancer Metastasis Inhibition （Speech，General）
3.	2023/05/25	Polysulfide donor can enhance the bacteria killing capability of macrophage and neutrophil. （Speech，General）
4.	2022/09/29	A chemotaxis inhibitory agent selected using “TAXIScan” suppresses pancreatic cancer proliferation and metastasis. （Speech，General）
5.	2021/12/02	Finding Flavor and fragrance compositions to inhibit binding of Virus RBD with human ACE2 （Speech，General）
6.	2021/11/05	SARS-CoV-2 Spike protein RBD binding to human ACE2 is inhibited by Flavors and fragrances （Speech，General）
7.	2021/09/07	ROS-generating Nox4 promotes the directed migration of endothelial cells （Speech，General）
8.	2021/09/07	Inhibition of SARS-CoV-2 RBD binding to human ACE2 by Flavors and fragrances （Speech，General）
9.	2020/10/01	HSP90 inhibition suppresses not only cell proliferation but also chemotaxis in esophageal squamous cell carcinoma （Speech，General）
10.	2020/10/01	Eextracellular S100A11 upregulates mobility of pancreatic cancer cells through activation of surrounding fibroblasts. （Poster notice，General）
11.	2020/10/01	DKK3 regulates malignant property of head and neck squamous cell carcinoma via phosphorylation of Akt. （Poster notice，General）
12.	2020/10/01	NOX4 on lymphatic endothelial cells (LEC) plays an important role on the migration of pancreatic cancer cells towards lymphatics. （Speech，General）
13.	2019/12/11	Chemotaxis of human peripheral regulatory T cells is inhibited by LEM （Poster notice，General）
14.	2019/11/08	Antitumor effects of 2-deoxy-D-glucose encapsulated PLGA nanoparticles against hepatocellular carcinoma in terms of tumor immunity （Poster notice，General）
15.	2019/04/01	Comparing effects of small molecular weight compounds on proliferation and chemotaxis of pancreatic cancer cells （Poster notice，General）
16.	2018/10/22	Heat shock protein 90 (HSP90) inhibitor as a candidate treatment option for gastrointestinal stromal tumor with acquired resistance for conventional receptor tyrosine kinase inhibitors （Poster notice，General）
17.	2018/10/10	A new anti-tumor drug for regulating cell dynamics. （Speech，Panelist at Symposium/Workshop (Applied)）
18.	2018/09/27	Migration of Pancreatic Cancer cell BxPC-3 is suppressed by ROS （Speech，General）
19.	2018/10/27	CX5461, a selective Polymerase I inhibitor, induces autophagy and suppresses the growth of leukemia cell lines. （Poster notice，General）
20.	2017/12/06	The Effect of ROS on the chemotaxis of Inflammatory cells （Poster notice，General）
21.	2017/10/30	ROS suppress the cellular chemotaxis （Poster notice，General）
22.	2017/10/23	Dipeptidyl peptidase 4 inhibitors reduce hepatocellular carcinoma by activating natural killer cell chemotaxis in mice （Poster notice，General）
23.	2017/04/27	Knockdown of DKK3 gene reduces malignant properties of oral squamous cell carcinoma-derived cells （Poster notice，General）
24.	2017/04/03	Heat shock protein 90 inhibitors suppress PDGFRA reactivation and other receptor tyrosine kinase activation important in drug resistant gastrointestinal stromal tumors. （Poster notice，General）
25.	2016/11/11	Dipeptidyl peptidase 4 (DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma （Poster notice，General）
26.	2016/10/06	Exploring serum factors for evoking and promoting cancer metastasis （Poster notice，General）
27.	2016/10/06	HSP90 inhibitor inhibit the activation of proliferation, chemotaxis and EMT in pancreatic cancer cells （Speech，General）
28.	2016/05/18	HSP90 inhibitor inhibit the activation of multiple kinase pathways and migration of pancreatic cancer cells. （Poster notice，General）
29.	2015/10/10	Functional analyses of DKK3 in oral squamous cell carcinoma cell lines （Poster notice，General）
30.	2015/10/09	CD26 (DPP-4) as a molecular target for HCC treatment （Poster notice，General）
31.	2015/10/09	HSP90 inhibitor inhibit the activation of multiple kinase pathways of pancreatic cancer cells （Speech，General）
32.	2015/07/10	Suppressing pancreatic cancer metastasis by small molecular compunds （Poster notice，General）
33.	2015/04/20	The new molecular target therapy of Hsp90 inhibition in esophageal squamous cell carcinoma （Poster notice，General）
34.	2014/12/10	A tryptophan metabolite, kynurenine suppresses chemotaxis of Jurkat T-cells induced by chemokine, SDF-1alpha （Speech，Panelist at Symposium/Workshop (Applied)）
35.	2014/11/25	Basic research for inhibiting pancreatic cancer metastasis: Gemcitabine vs Dasatinib （Poster notice，General）
36.	2014/11/13	Effect of HSP90 inhibitor on proliferation and migration in esophageal squamous cell carcinoma （Speech，General）
37.	2014/09/25	Antitumor effect of HSP90 inhibitor against esophageal cancer （Poster notice，General）
38.	2014/04/12	Evaluation of human melanocyte migration in vitro by a small scale but powerful method utilizing the real-time cell mobility assay device （Speech，Panelist at Symposium/Workshop (Appointed)）
39.	2013/12/13	Formyl peptides and chemokines augment neutrophil accumulation at the inflammation sites whereas lipid mediators support the recruitment. （Poster notice，General）
40.	2013/09/11	Effects of PAA and 4-AP on chemotaxis of eosinophil derived from human peripheral blood （Poster notice，General）
41.	2013/09/09	Relationship between macrophage differentiation and the chemotactic activity toward damaged muscle cells. （Poster notice，General）
42.	2012/11/09	Kynurenine attenuates chemotaxis of Jurkat T-cells induced by chemokine, SDF-1 alpha （Poster notice，General）
43.	2012/10/23	Robust directionality in neutrophil chemotaxis toward the end-target chemoattractant fMLP: an optical approach to the mechanism. （Poster notice，General）
44.	2012/09/21	The suppressive effect for chemotaxis and anticancer effect of eicosapentanoic acid in TE-1 cell line. （Poster notice，General）
45.	2012/03/27	The robust directionality in neutrophil chemotaxis to fMLP: an optical approach to the mechanism. （Poster notice，General）
46.	2009/12/28	Cellular Dynamics Analyzed with TAXIScan - fluorescent imaging of cellular chemotaxis for development of anti-cancer drugs. （Speech，Panelist at Symposium/Workshop (Other)）
47.	2009/12/05	Cellular Dynamics Analyzed with TAXIScan – fluorescent imaging of cellular chemotaxis for development of anti-cancer drugs. （Speech，Panelist at Symposium/Workshop (Other)）
48.	2009/07/06	TAXISCAN SYSTEM, A UNIQUE TECHNOLOGY FOR FUNCTIONAL ANALYSIS OF LEUKOCYTES. （Poster notice，General）
49.	2009/07/03	TAXIScan technology, used for analyses of chemotaxis of leukocytes from lung disease patients and for mast cell degranulation. （Poster notice，General）
50.	2009/01	Molecular mechanism of macrophage infiltration into obese adipose tissue - Analysis with TAXIScan, a real-time horizontal chemotaxis assay system - （Poster notice，General）
51.	2007/06	Various physical parameters in the process of chemotaxis tracking using a novel optical device -TAXIScan. （Poster notice，General）
52.	2006/01	A novel chemotactic assay device TAXIScanTM clarifies different migration pattern of human leukocytes （Poster notice，General）
53.	2005/07/07	A novel chemotaxis assay device TAXIScanTM can distinguish difference of migration pattern in human monocytes chemotaxis. （Poster notice，General）
54.	2005/06/12	A novel chemotaxis assay device TAXIScanTM can distinguish difference of migration pattern in human neutrophil and monocyte chemotaxis. （Poster notice，General）
55.	2004/07/01	A novel chemotaxis assay chamber system TAXIScan; powerful tool for both quantitative and image analysis of host defense function of hematopoteic cells. （Poster notice，General）
56.	2004/07/01	Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. （Poster notice，General）
57.	2003/06/08	Rac2-null macrophages have defects in superoxide production and Fcg-R-mediated phagocytosis. （Poster notice，General）
58.	2002/12/06	Rac2-null macrophages have defects in superoxide production and Fc-R-mediated （Poster notice，General）
59.	2001/06/10	Exogenous Rac protein rescues the functional defects of in Rac2-/- Neutrophils （Poster notice，General）
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■ Professional Organizations

1.	1997～	The Japanese Biochemical Society
2.	1997～	The Molecular Biology Society of Japan
3.	1997～	JAPANESE SOCIETY FOR BACTERIOLOGY
4.	2003～	Japanese Society for Immunology
5.	2003～	Japanese Society for Host-Defense Research;JSHDR
6.	2004～	International Symposium on Molecular Cell Biology of Macrophages
7.	2009～	The Japanese Society of Inflammation and Regeneration
8.	2009～	VCF
9.	2010～	The Japanese Society of Immunotoxicology
10.	2010～	The Japanese Society for Neuroimmunology
11.	2014/08～	Japanese Cancer Association.
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