|
Akira Yamauchi
Department Kawasaki Medical School Kawasaki Medical School, Department of Biochemistry, Position Professor |
|
| Article types | 原著 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Anti-fatigue activity of methyl dihydrojasmonate and linalool in a rat model evaluated by a novel index for neuro-immune and oxidative stress interactions |
| Journal | Formal name：Scientific Reports Abbreviation：Sci Rep ISSN code：20452322 |
| Domestic / Foregin | Foregin |
| Publisher | Springer Nature Limited |
| Volume, Issue, Page | 14 |
| Total page number | 10 |
| Author and coauthor | Yasumitsu Nishimura, Kenta Nomiyama, Shuichiro Okamoto, Mika Igarashi, Yukino Sato, Hikaru Okamoto, Ayasa Kamezaki, Masumi Itadani, Futoshi Kuribayashi & Akira Yamauchi |
| Authorship | Last author,Corresponding author |
| Publication date | 2024/05/09 |
| Summary | Avoiding fatigue is a long-standing challenge in both healthy and diseased individuals. Establishing objective standard markers of fatigue is essential to evaluate conditions in spatiotemporally different locations and individuals and identify agents to fight against fatigue. Herein, we introduced a novel method for evaluating fatigue using nervous system markers (including dopamine, adrenaline, and noradrenaline), various cytokine levels (such as interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-10, IL-2, IL-5 and IL-17A), and oxidative stress markers (such as diacron-reactive oxygen metabolites [d-ROMs] and biological antioxidant potential [BAP]) in a rat fatigue model. Using this method, the anti-fatigue effects of methyl dihydrojasmonate (MDJ) and linalool, the fragrance/flavor compounds used in various products, were assessed. Our method evaluated the anti-fatigue effects of the aforementioned compounds based on the changes in levels of the nerves system markers, cytokines, and oxidative stress markers. MDJ exerted more potent anti-fatigue effects than linalool. In conclusion, the reported method could serve as a useful tool for fatigue studies and these compounds may act as effective therapeutic agents for abrogating fatigue symptoms. |
| DOI | https://doi.org/10.1038/s41598-024-60266-5 |
| PMID | 38724532 |