ヤマムラ　マサヒロ   Masahiro Yamamura   山村　真弘    所属   川崎医科大学  医学部    職種   学長付講師
言語種別	日本語
発表タイトル	神経内分泌腫瘍に対するHsp90阻害剤の抗腫瘍効果
会議名	第71回日本癌学会学術総会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	◎山村真弘, 平井敏弘, 濃野勉, 岡脇誠, 弘中克治, 山口佳之
発表年月日	2012/09/20
開催地 （都市, 国名）	札幌
学会抄録	第71回日本癌学会学術総会抄録集 337
概要	Heat shock protein（Hsp90） has numerous cellular functions, including promotion of proper protein folding, and stabilizes a number of oncogenic proteins, many of which are overexpressed in cancers. The objective of this study is to evaluate an antitumor effect of Hsp90 inhibitor, called 17-AAG, in neuroendocrine tumor （NET） cell lines. NET cell line （COLO320） was treated with Hsp90 inhibitor, 17-AAG, to examine the effect on proliferation of NET cells by using the WST-1 proliferation assay. 17-AAG inhibited cell proliferation in NET cells in a dose- and time-dependent manner. 17-AAG was also effective to induce apoptosis in NET cells as determined with FACS analysis and immunochemistry. The Hsp90 inhibitor is useful as an antitumor drug in NET, inhibiting the proliferation of NET cells through novel mechanism.