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Shinichiro Nishimatsu
Department Kawasaki Medical School Kawasaki Medical School, Department of Natural Sciences, Position Professor |
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| Article types | 総説 |
| Language | English |
| Peer review | Peer reviewed |
| Title | Bone Morphogenetic Protein-3 family members and their biological functions. |
| Journal | Formal name：Frontiers in bioscience : a journal and virtual library Abbreviation：Front Biosci ISSN code：10939946/10934715 |
| Volume, Issue, Page | 9,pp.1520-1529 |
| Author and coauthor | Hino Jun, Kangawa Kenji, Matsuo Hisayuki, Nohno Tsutomu, Nishimatsu Shin-ichiro |
| Authorship | Last author |
| Publication date | 2004/05 |
| Summary | Bone morphogenetic protein-3 and 3b (BMP-3 and BMP-3b) together represent a unique subgroup of the BMP family. BMP-3b shares 82% amino acid identity with BMP-3 in the mature region (ligand domain), but only 37% in the pro-region (pro-domain). In osteoblasts, BMP-3 and 3b have similar antagonistic activity against BMP-2, but they are differentially regulated. In developing embryos, BMP-3 and 3b have different dorsalizing activities. BMP-3b triggers secondary head formation in an autonomous manner, whereas BMP-3 induces aberrant tail formation. Loss-of-function analysis demonstrates that coordinated activity of xBMP-3b and cerberus, a head inducer, are required for head formation in Xenopus embryos. At the molecular level, BMP-3b antagonizes both nodal-like proteins (Xnr1 and derriere) and ventralizing BMPs (BMP-2 and ADMP), whereas BMP-3 only antagonizes ventralizing BMPs. Moreover, BMP-3b, but not BMP-3, associates with the monomeric form of Xnr1, a nodal-like protein. These molecular features of BMP-3 and 3b are due to their distinct pro-regions. These findings suggest that the processing of precursor regions and assembly of BMP-3 and 3b are important in various developmental processes and organogenesis. |
| DOI | 10.2741/1355 |
| Document No. | 14977563 |