ニシマツ　シンイチロウ   Shinichiro Nishimatsu   西松　伸一郎    所属   川崎医科大学  医学部 一般教養　自然科学    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos.
掲載誌名	正式名：Mechanisms of development 略　 称：Mech Dev ISSNコード：09254773/18726356
巻・号・頁	74(1-2),pp.75-88
著者・共著者	Nishimatsu Shin-ichiro, Thomsen Gerald H
担当区分	筆頭著者
発行年月	1998/06
概要	Bone morphogenetic proteins (BMPs) perform diverse functions in vertebrate development. Here we demonstrate that the heterodimeric BMP-4/7 protein directly induces ventral mesoderm and blood in Xenopus animal caps, and BMP-2/7 heterodimers may function similarly. We also provide indirect evidence that BMP heterodimers function in embryos, using assays with dominant-negative BMP ligands. Homodimeric BMP-2 and BMP-4 proteins do not induce mesoderm, but they ventralize mesoderm induction by activin. In contrast, BMP-7 protein interferes with mesoderm induction by activin, but BMP-7 stimulates ventral mesoderm induction by the heterodimer, BMP-4/7. This novel property of BMP-7 distinguishes it from other BMPs. BMP-7 may therefore function in early embryogenesis to antagonize activin signals and potentiate BMP signals. We propose that BMP heterodimers convey signals for ventral mesoderm induction and patterning in Xenopus development.
DOI	10.1016/S0925-4773(98)00070-7
文献番号	9651485