Shinichiro Nishimatsu    Department   Kawasaki Medical School  Kawasaki Medical School, Department of Natural Sciences,    Position   Professor
Article types	原著
Language	English
Peer review	Peer reviewed
Title	Heart formative factor(s) is localized in the anterior endoderm of early Xenopus neurula.
Journal	Formal name：Roux's Archives of Developmental Biology ISSN code：0930035X
Volume, Issue, Page	205(5-6),pp.282-289
Author and coauthor	Tonegawa A, Moriya M, Tada M, Nishimatsu S, Katagiri C, Ueno N.
Publication date	1996
Summary	To elucidate the mechanisms of early heart morphogenesis in Xenopus laevis, we examined the effect of endoderm on heart morphogenesis in the early Xenopus neurula. Explants of anterior ventral (presumptive heart) mesoderm from early neurula were cultured alone or in combination with endoderm dissected from various regions. Heart formation was scored by an original heart index based on morphology. These explant studies revealed that anterior ventral endoderm plays a critical role in heart morphogenesis. Furthermore, we found that it was possible to confer this heart-forming ability on posterior ventral endoderm by the injection of poly(A)+ RNA from stage 13 anterior endoderm. These results imply that the heart formative factor(s) is localized in the anterior endoderm of the early neurula and that at least part of this activity is encoded by mRNA(s).
DOI	10.1007/BF00365806