教員情報 - 中野　和久

（最終更新日：2024-05-17 13:59:57）

  ナカノ　カズヒサ   Kazuhisa Nakano
  中野　和久
   所属   川崎医科大学医学部臨床医学　リウマチ・膠原病学

職種特任教授

■ 著書

1.	2023/03	部分執筆	JAK阻害薬の安全性に関するupdate「RAにおける悪性腫瘍とJAK阻害薬」「リウマチ科」
2.	2022/10/10	部分執筆	「改訂第10版　リウマチ専門医試験　例題と解説」

■ 学術雑誌

1.	2024/03/21	総説	Prognosis and prognostic factors of lung cancer complications in patients with rheumatoid arthritis
2.	2024/01/31	症例報告	GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
3.	2023/10/03	症例報告	Computed tomography for malignancy screening in patients with rheumatoid arthritis before initiation of disease modifying antirheumatic drug
4.	2023/03	原著	特集　JAK阻害薬の安全性に関するupdate「RAにおける悪性腫瘍とJAK阻害薬」
5.	2022/11/15	症例報告	Acromegaly: A Rare Cause of Knee Pain
6.	2022/09/16	症例報告	Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression
7.	2022/07/22	原著	TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1
8.	2022/05/14	原著	IL-17A promotes vascular calcification in an ex vivo murine aorta culture
9.	2022/03/10	原著	IL-17A promotes vascular calcification in an ex vivo murine aorta culture
10.	2022/03/04	症例報告	Short-Term Prognostic Factors in Hospitalized Herpes Zoster Patients and Its Associated Cerebro-Cardiovascular Events: A Nationwide Retrospective Cohort in Japan
11.	2020/08/20	原著	A case of systemic lupus erythematosus in which Cushing’s syndrome caused by adrenal adenoma accidentally occurred during long-term maintenance therapy with corticosteroids.
12.	2020/06/15	原著	Favorable efficacy of rituximab in ANCA-associated vasculitis patients with excessive B cell differentiation.
13.	2020/06/08	原著	Differential long-term retention of biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis by age group from the FIRST registry.
14.	2020/05/04	原著	Two patients with mixed connective tissue disease complicated by pulmonary arterial hypertension showing contrasting responses to pulmonary vasodilators.
15.	2020/04/20	原著	A case of bone destruction caused by chronic non-bacterial osteomyelitis (CNO) successfully repaired with a tumor necrosis factor-α (TNF-α) inhibitor, adalimumab.
16.	2020/03/27	原著	Clinical aspects in patients with rheumatoid arthritis complicated with lymphoproliferative disorders without regression after methotrexate withdrawal and treatment for arthritis after regression of lymphoproliferative disorders.
17.	2020/03/12	原著	Systemic lupus erythematosus with repeated protein-losing enteropathy resulting from different pathological conditions: a case report.
18.	2020/03/01	原著	IgG4-type Multiple Myeloma with Diffuse Enlargement of the Thyroid Requiring Differentiation from IgG4-related Disease.
19.	2020/02/05	原著	Correlation between serological biomarkers of extracellular matrix turnover and lung fibrosis and pulmonary artery hypertension in patients with systemic sclerosis.
20.	2020/02/05	原著	The additive effects of hydroxychloroquine to maintenance therapy with standard of care in patients with systemic lupus erythematosus.
21.	2020/01/15	原著	5-year remission rate after the discontinuation of adalimumab in patients with rheumatoid arthritis: Long-term follow-up results of the HONOR study.
22.	2020/01/07	原著	2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases.
23.	2020	原著	強直性脊椎炎に対してTNF-α阻害薬で加療中に発症した掌蹠膿疱症の2症例
24.	2019/12/01	原著	Distinctive association of peripheral immune cell phenotypes with capillaroscopic microvascular patterns in systemic sclerosis.
25.	2019/11/22	原著	An autopsy case of a patient with systemic sclerosis who developed marked pulmonary hypertension becase of pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma.
26.	2019/10/19	原著	Sustained discontinuation of infliximab with a raising-dose strategy after obtaining remission in patients with rheumatoid arthritis: the RRRR study, a randomised controlled trial.
27.	2019/08/21	原著	Focal Eosinophilic Myositis.
28.	2019/06/22	原著	Comparative study of corticosteroid monotherapy, and TNF inhibitors with or without corticosteroid in patients with refractory entero-Behcet's disease.
29.	2019/06	原著	IL-6 and sIL-6R induces STAT3-dependent differentiation of human VSMCs into osteoblast-like cells through JMJD2B-mediated histone demethylation of RUNX2.
30.	2019/03/01	原著	An Autopsy Case with Cerebral Hemorrhaging due to disseminated Aspergillosis During Glucocorticoid Therapy for Overlap Syndrome of Systemic Lupus Erythematosus and Systemic Sclerosis.
31.	2019/03	原著	Effectiveness and safety of hydroxychloroquine therapy with or without corticosteroid in patients with systemic lupus erythematosus.
32.	2019/03	原著	Type I and II interferons commit to abnormal expression of chemokine receptor on B cells in patients with systemic lupus erythematosus.
33.	2019/02/15	原著	Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept.
34.	2019/02/01	原著	Precision medicine using different biological DMARDs based on characteristic phenotypes of peripheral T helper cells in psoriatic arthritis.
35.	2019/02/01	原著	Small Cell Lung Cancer Patient with Anti-transcriptional Intermediary Factor 1γ Antibody Who Developed Dermatomyositis after Successful Chemoradiotherapy.
36.	2019/01/09	原著	The two cases of Acute acalculous cholecystitis associated with Systemic Lupus Erythematosus(SLE) presented different clinical aspects.
37.	2019/01/01	原著	Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies.
38.	2019	原著	無症候性IgG4関連胆嚢炎を伴ったIgG4関連疾患の一例
39.	2018/12/10	原著	Th22 Cells Promote Osteoclast Differentiation via Production of IL-22 in Rheumatoid Arthritis.
40.	2018/10/26	原著	Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis.
41.	2018/08/28	原著	Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus.
42.	2018/08/01	原著	IgG4-related Pleuritis with Elevated Adenosine Deaminase in Pleural Effusion: A Case Report.
43.	2018/06/01	原著	Successful Management of Pregnancy in a Patient with Systemic Lupus Erythematosus-associated Pulmonary Arterial Hypertension.
44.	2018/06	原著	A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab
45.	2018/06	原著	Comparison of efficacy of TNF inhibitors and abatacept in patients with rheumatoid arthritis; Adjusted with propensity score matching.
46.	2018/06	原著	Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC).
47.	2018/05/17	原著	Successful treatment with etanercept in a case of seronegative rheumatoid arthritis with corticosteroid/methotrexate-resistant pemphigus erythematosus.
48.	2018/03/01	原著	Correlation of T follicular helper cells and plasmablasts with the development of organ involvement in patients with IgG4-related disease.
49.	2018/01/01	原著	Differential effects of biological DMARDs on peripheral immune cell phenotypes in patients with rheumatoid arthritis.
50.	2018	原著	High level of adenosine deaminase in pleural effusion in patient with IgG4-related disease: A case report.
51.	2018	原著	MPO-ANCA陽性を呈した抗GBM抗体型腎炎の1例
52.	2018	原著	リツキシマブがいずれにも奏効したオーバーラップ症候群（全身性強皮症・関節リウマチ・全身性エリテマトーデス）の一例
53.	2018	原著	外転神経麻痺で発症した好酸球性多発血管炎性肉芽腫症の一例
54.	2018	原著	消化管潰瘍を反復した骨髄異形成症候群関連結節性多発動脈炎の１例
55.	2018	原著	上大静脈症候群を呈した血管型ベーチェット病の1例
56.	2017/12	原著	Relapsing Polychondritis Diagnosed by Fusion Images of Gallium-67 Uptake on Computed Tomography and Single-Photon-Emission Computed Tomography.
57.	2017/11/08	原著	Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.
58.	2017/09/01	原著	Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.
59.	2017	原著	A case of rheumatoid arthritis treated with infliximab who developed disseminated Penicillium marneffei infection after visit to Thailand.
60.	2017	原著	Peripheral immunophenotyping identifies three subgroups based on T cell heterogeneity in lupus patients.
61.	2017	原著	The occurrence of hypertrophic pachymeningitis with infiltration of IgG4-positive plasma cells and with different aetiology: report of three cases.
62.	2017	原著	治療抵抗性の関節リウマチ(RA)と全身性エリテマトーデス(SLE)の併発に対しリツキシマブ(RTX)投与にて疾患活動性を制御できた1例
63.	2016/08/31	原著	Clinical, radiographic and functional efficacy of abatacept in routine care for rheumatoid arthritis patients: Abatacept Leading Trial for RA on Imaging Remission (ALTAIR) study.
64.	2016	原著	Comparison of the efficacies of abatacept and tocilizumab in patients with rheumatoid arthritis by propensity score matching.
65.	2015/07/31	原著	Histamine inhibits differentiateon of skin fibroblasts into myofibroblasts.
66.	2015/05	原著	IL-6/STAT3 signaling pathway contributes to chondrogenic differentiation of human mesenchymal stem cells.
67.	2015/02	原著	Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study.
68.	2015	原著	α-グルコシダーゼ阻害薬による腸管気腫症を認めたClinically Amyopathic Dermatomyositis （CADM）の一例
69.	2014/05	原著	Study on the safety and efficacy of tocilizumab, an anti-IL-6 receptor antibody, in patients with rheumatoid arthritis complicated with AA amyloidosis.
70.	2013/09/25	原著	Discontinuation of adalimumab after attaining disease activity score 28-erythrocyte sedimentation rate remission in patients with rheumatoid arthritis (HONOR study): an observational study.
71.	2013/07	原著	D1-like dopamine receptors antagonist inhibits cutaneous immune reactions mediated by Th2 and mast cells.
72.	2013/02/01	原著	Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes.
73.	2013/01	原著	DNA methylome signature in rheumatoid arthritis.
74.	2013	原著	Dopamine D2-like receptor signaling suppresses human osteoclastogenesis.
75.	2012/10	原著	Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway.
76.	2012/06	原著	Amplification of Toll-like receptor-mediated signaling through spleen tyrosine kinase in human B-cell activation.
77.	2012	原著	The JAK inhibitor tofacitinib regulates synovitis through inhibition of IFN-γ and IL-17 production by human CD4(+) T cells.
78.	2011/06	原著	Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production.
79.	2011/06	原著	Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice.
80.	2011/05/15	原著	Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and ovalbumin antigen-induced neutrophilic airway inflammation.
81.	2011/03/15	原著	Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model.
82.	2010/03	原著	Tacrolimus, a calcineurin inhibitor, overcomes treatment unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory rheumatoid arthritis.
83.	2009/06	原著	Dopamine released by dendritic cells polarizes Th2 differentiation.
84.	2008/08/22	原著	Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis.
85.	2008/07/01	原著	B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
86.	2008/02	原著	Interaction of galectin-9 with lipid rafts induces osteoblast proliferation through the c-Src/ERK signaling pathway.
87.	2007/06/29	原著	Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities.
88.	2007/05	原著	Activation signal transduction by beta1 integrin in T cells from patients with systemic lupus erythematosus.
89.	2007/04	原著	Rheumatoid synovial endothelial cells produce macrophage colony-stimulating factor leading to osteoclastogenesis in rheumatoid arthritis.
90.	2007/01	原著	Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death.
91.	2005/06	原著	Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus.
92.	2004/12	原著	Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytes.
93.	2004/08	原著	Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts.
94.	2004/07	原著	Macrophage inflammatory protein-1alpha induces hypercalcemia in adult T-cell leukemia.
95.	2004	原著	Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility.
96.	2004	原著	ループス脊髄炎による排尿障害並びにループス精神病にIV-CYが有効であった一症例
97.	2004	原著	多発性血栓塞栓症から卵巣明細胞腺癌が発見された１症例
98.	2004	原著	著明な大動脈弁・僧帽弁破壊により急性心不全を呈した顕微鏡的多発血管炎の１症例
99.	2004	原著	慢性Ｃ型肝炎に伴うクリオグロブリン血症にて増悪した関節症状にIFN－α療法が奏効したRAの一例
100.	2003/03/27	原著	Crosslinking of CD44 on human osteoblastic cells upregulates ICAM-1 and VCAM-1.
101.	2003	原著	bFGF局所塗布が著効した膠原病関連難治性皮膚潰瘍の2症例
102.	2003	原著	Systemic lupus erythematosusに伴うステロイド抵抗性溶血性貧血にシクロホスファミドパルス療法が奏功した2症例
103.	2003	原著	急性進行性の中枢神経症状を呈したSjogren症候群の1例
104.	2003	原著	強皮症に併発した激烈な胃・腸管浮腫に高気圧酸素療法が著効した１症例
105.	2003	原著	最適のリウマチ医療のための役割分担―第25回九州リウマチ学会パネルディスカッション全国アンケート結果より―
106.	2002	原著	シクロホスファミドパルス療法が奏効したＣＮＳループスと抗リン脂質抗体症候群の一症例
107.	2002	原著	関節リウマチに併発した二次性膀胱アミロイド症の1例
108.	2002	原著	多剤抵抗性関節リウマチへのシクロホスファミドパルス療法の効果
109.	2001/06	原著	Multiple hepatic infarction after transcatheter arterial infusion with SMANCS.
110.	2001	原著	大量輸血による続発性ヘモクロマトーシスにより副甲状腺機能低下症を来した1例
111.	2000	原著	抗ICAM-1抗体‐発現ベクター複合体を用いた慢性関節リウマチ滑膜細胞への遺伝子導入
112.	2000	原著	全身性エリテマトーデス経過中肺高血圧症を併発した１症例
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■ 学会発表

1.	2024/04/20	乳がんの合併・既往が関節リウマチ罹患女性の疾患活動性制御に与える影響～SETOUCHI-RAレジストリーから～（ポスター掲示，一般）
2.	2024/04/19	顕微鏡的多発血管炎の寛解導入療法中に突然死し、病理解剖で十二指腸動脈中型動脈破裂による腹腔内出血と判明した症例（ポスター掲示，一般）
3.	2024/04/18	抗核抗体陽性は寛解期RAにおける倦怠感残存のリスクとなる～SETOUCHI-RAレジストリーより～（ポスター掲示，一般）
4.	2024/04/18	腸管超音波検査での橈骨・尺骨動脈径測定による全身性強皮症における手指潰瘍形成リスクの検討（口頭，一般）
5.	2023/12/02	ANCA 関連壊死性糸球体腎炎を合併したメサンギウム増殖性ループス腎炎の一例（口頭，一般）
6.	2023/12/02	寛解期に倦怠感が残存するRA 患者の特徴と背景因子の検討　SETOUCHI-RA レジストリーより（口頭，一般）
7.	2023/12/02	関節リウマチ患者に合併した肺癌の予後および予後規定因子（口頭，一般）
8.	2023/12/02	竹節状声帯で発症したSLE2 症例の臨床的特徴（口頭，一般）
9.	2023/12/01	脳血管と冠動脈に不可逆的血管病変を呈したIgG4 関連疾患の2 症例（口頭，一般）
10.	2023/12/01	複雑核型を有する骨髄異形成症候群に合併した巨細胞性動脈炎症例（口頭，一般）
11.	2023/10/21	造影MRIを用いてIgG4関連疾患に併発した中枢神経血管炎と診断し，活動性を経時的に確認しえた一例（口頭，一般）
12.	2023/06/20	竹節状声帯結節をきっかけに診断しえたSLEの２症例（口頭，一般）
13.	2023/06/03	タダラフィルが奏効した皮膚筋炎関連間質性肺炎合併PHの症例（口頭，一般）
14.	2023/05/21	COVID-19ワクチン接種後に器質化肺炎を伴い発症した関節リウマチの1例（一般）
15.	2023/04/26	関節リウマチ患者に合併した肺癌の予後および予後規定因子についての検討（口頭，一般）
16.	2022/12/03	間質性肺炎合併抗ARS抗体陽性炎症性筋疾患における再燃リスクの検討（口頭，一般）
17.	2022/12/02	不明熱精査中に肺高血圧症合併を契機に肺動脈限局高安動脈炎と診断した症例（口頭，一般）
18.	2021/12/11	左房粘液腫を合併した巨細胞性動脈炎に対してトシリズマブを使用した一例（口頭，一般）
19.	2021/12/10	エルトロンボパグよりロミプロスチムへの切替えが奏効したリツキシマブ抵抗性のSLE合併自己免疫性血小板減少症の一例（口頭，一般）
20.	2021/12/08	The investigation of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models （ポスター掲示，一般）
21.	2021/11/06	腎細胞癌に対するニボルマブ・イピリムマブ併用治療により炎症性関節炎と1型糖尿病を発症した症例（口頭，一般）
22.	2021/10/28	モデルマウスを用いたTNF受容体関連周期性症候群（TRAPS）の病態解析（一般）
23.	2021/08/28	The study of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models （口頭，一般）
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■ 所属学会

1.		日本リウマチ学会
2.		∟ 評議員
3.		日本臨床免疫学会
4.		∟ 広報・教育・次世代育成委員
5.		∟ 評議員