スギモト　コウヘイ   杉本　昂平    所属   川崎医療福祉大学  医療技術学部 診療放射線技術学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	New field-in-field with two reference points method for whole breast radiotherapy: Dosimetric analysis and radiation-induced skin toxicities assessment.
掲載誌名	正式名：Molecular and clinical oncology 略　 称：Mol Clin Oncol ISSNコード：20499469/20499450
掲載区分	国外
巻・号・頁	15(3),pp.193
著者・共著者	Nouha Tekiki, Masahiro Kuroda, Hinata Ishizaka, Abdullah Khasawneh, Majd Barham, Kentaro Hamada, Kohei Konishi, Kohei Sugimoto, Kuniaki Katsui, Soichi Sugiyama, Kenta Watanabe, Kotaro Yoshio, Norihisa Katayama, Takeshi Ogata, Hiroki Ihara, Susumu Kanazawa, Junichi Asaumi
発行年月	2021/09
概要	The usefulness of the field-in-field with two reference points (FIF w/ 2RP) method, in which the dose reference points are set simultaneously at two positions in the irradiation field and the high-dose range is completely eliminated, was examined in the present study with the aim of decreasing acute skin toxicity in adjuvant breast radiotherapy (RT). A total of 573 patients with breast cancer who underwent postoperative whole breast RT were classified into 178 cases with wedge (W) method, 142 cases with field-in-field without 2 reference points (FIF w/o 2RP) method and 253 cases with FIF w/ 2RP method. Using the FIF w/ 2RP method, the high-dose range was the lowest among the three irradiation methods. The planning target volume (PTV) V105% and the breast PTV for evaluation (BPe) V105% decreased to 0.09 and 0.10%, respectively. The FIF w/ 2RP method vs. the FIF w/o 2RP method had a strong association (η) with PTV V105% (η=0.79; P<0.001) and BPe V105% (η=0.76; P<0.001). The FIF w/ 2RP method had a significant impact on lowering the skin toxicity grade in weeks 3 and 4, and increasing the occurrence of skin toxicity grade 0. The FIF w/ 2RP method vs. the W method had a moderate association with skin toxicity grade at week 3 (η=0.49; P<0.001). Using the FIF w/ 2RP method, the high-dose range V105% of the target decreased to 0%, and skin adverse events were decreased in conjunction. For patients with early-stage breast cancer, particularly patients with relatively small-sized breasts, the FIF w/ 2RP method may be an optimal irradiation method.
DOI	10.3892/mco.2021.2355
PMID	34349992