Faculty Information - Hajime Nagasu

（Last updated : 2024-06-05 14:07:31）

Hajime Nagasu
Department Kawasaki Medical School Kawasaki Medical School, Department of Nephrology and Hypertension,

Position Associate Professor

■ Journal

1.	2024/03/20	Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease
2.	2024/02	Oxidative stress and the role of redox signalling in chronic kidney disease
3.	2024/01/09	A case series of Fabry diseases with CKD in Japan.
4.	2023/10/01	Insights into the regulation of glomerular filtration rate by the Keap1-Nrf2 pathway
5.	2023/09	Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis.
6.	2023/07/19	eGFR slope as a surrogate endpoint for clinical study in early stage of chronic kidney disease: from The Japan Chronic Kidney Disease Database
7.	2023/07/04	Kidney outcomes associated with haematuria and proteinuria trajectories among patients with IgA nephropathy in real-world clinical practice: The Japan Chronic Kidney Disease Database
8.	2023/06	The Impact of Potassium Binders on Mortality in Patients with Hyperkalemia: A Single-Center Study
9.	2023/02	Genome-wide association study of the risk of chronic kidney disease and kidney-related traits in the Japanese population: J-Kidney-Biobank
10.	2021/11	Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function
11.	2021/11	Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database.
12.	2021/08/27	Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation
13.	2021/05/11	Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia.
14.	2021/04/17	SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.
15.	2020/12/13	Glomerular Classification Using Convolutional Neural Networks Based on Defined Annotation Criteria and Concordance Evaluation Among Clinicians.
16.	2020/11/03	Association of Arterial Stiffness With Kidney Function Among Adults Without Chronic Kidney Disease.
17.	2020/07/20	Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB).
18.	2020/05/01	Klotho is a novel therapeutic target in peritoneal fibrosis via Wnt signaling inhibition.
19.	2020/04/30	J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan.
20.	2019/11	Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.
21.	2019/07	Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice Using In Vivo Imaging.
22.	2019/04	Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Fas^lpr Mice.
23.	2019/01	5-Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury.
24.	2018/10/03	The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.
25.	2017/08	Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.
26.	2016/01	Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.
27.	2015/08	Deficiency of endothelial nitric oxide signaling pathway exacerbates peritoneal fibrosis in mice.
28.	2014	Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats.
29.	2013/04	Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status.
30.	2013/03	Angiostatin production increases in response to decreased nitric oxide in aging rat kidney.
31.	2012/12	Establishment of a blood purification system for renal failure rats using small-size dialyzer membranes.
32.	2012/12	Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.
33.	2012/08	Tacrolimus Induces Glomerular Injury via Endothelial Dysfunction Caused by Reactive Oxygen Species and Inflammatory Change.
34.	2012/06	Endothelial dysfunction promotes the transition from compensatory renal hypertrophy to kidney injury after unilateral nephrectomy in mice.
35.	2012/03	Azelnidipine attenuates glomerular damage in Dahl salt-sensitive rats by suppressing sympathetic nerve activity.
36.	2011/04	Overexpression of klotho protein modulates uninephrectomy-induced compensatory renal hypertrophy by suppressing IGF-I signals.
37.	2011/02	Mitochondrial damage-induced impairment of angiogenesis in the aging rat kidney.
38.	2011	Comparison of Combination Therapy of Olmesartan plus Azelnidipine or Hydrochlorothiazide on Renal and Vascular Damage in SHR/NDmcr-cp Rats.
39.	2010/11	Histopathological manifestations of membranoproliferative glomerulonephritis and glomerular expression of plasmalemmal vesicle-associated protein-1 in a patient with polycythemia vera
40.	2010/09	Renal denervation reduces glomerular injury by suppressing NAD(P)H oxidase activity in Dahl salt-sensitive rats.
41.	2009/12	Azelnidipine exerts renoprotective effects by improvement of renal microcirculation in angiotensin II infusion rats.
42.	2009/09	Reactive oxygen species mediate compensatory glomerular hypertrophy in rat uninephrectomized kidney
43.	2009/08	A Case Report of Efficiency of Double Filtration Plasmapheresis in Treatment of Goodpasture's Syndrome.
44.	2009/05	High dietary protein intake induces endothelial dysfunction in uninephrectomized rats
45.	2007/02/20	Bilateral ureteral stenosis and duodenal perforation in a patient with dermatomyositis.
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■ Presentation

1.	2024/05/23	Investigating the effects of low-level and transient DNA damage on kidney health in a novel mouse model of aging （Poster notice，General）
2.	2023/11/03	Association of Serum Magnesium Concentration with Renal Prognosis in Patients with CKD （Poster notice，General）
3.	2023/11/02	Elucidation of the Molecular Mechanism of Albuminuria Improvement by Nonsteroidal Mineralocorticoid Receptor (MR) Antagonists Focusing on Podocyte Calcium (Ca2+) Dynamics （Poster notice，General）
4.	2022/10/15	Endothelial dysfunction exacerbates kidney dysfunction in ageing kidney via activation of inflammasome （Poster notice，General）
5.	2022/10/15	eNOS-NO pathway regulates inflammasome activation in diabetic mice via modulation of CEBP translocation （Poster notice，General）
6.	2022/10/15	eNOS/NO signaling regulates renal interstitial fibrosis by increasing cytoplasmic beta-catenin degradation （Poster notice，General）
7.	2022/06/10	Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose‒Lowering Drugs in J‒CKD‒DB‒Ex （Speech，Panelist at Symposium/Workshop (Applied)）
8.	2022/02/20	Effect of sodium-glucose cotransporter 2 inhibitor, canagliflozin, on glomerular hyperfiltration and oxidative stressin mice with type 2 diabetes. （Speech，General）
9.	2021/02/28	Evaluation of glomerular hemodynamic changes by SGLT2 inhibitor and ARB in type 2 diabetic rats using in vivo imaging （Speech，General）
10.	2020/12/04	The role of an adaptor protein SH3BP2 in the pathogenesis of systemic lupus erythematosus （Poster notice，General）
11.	2020/11/07	SH3BP2 Deciency Ameliorates Murine Systemic Lupus Erythematosus （Poster notice，General）
12.	2020/10/24	SH3BP2 deficiency ameliorates murine systemic lupus erythematosus （Poster notice，General）
13.	2020/10/19	Effect of Zinc Deficiency on CKD Progression and Effect Modification by Hypoalbuminemia. （Poster notice，General）
14.	2020/10/19	eNOS/NO Signaling Attenuates Progression of Age-Related Kidney Diseases via Suppression of Inflammasome. （Poster notice，General）
15.	2020/10/19	Machine Learning Prediction of ESKD and Death in CKD Patients: Electronic Medical Record-Based Cohort Study. （Poster notice，General）
16.	2020/10/02	DEFICIENT OF ENOS/NO PATHWAY PROMOTES AKI TO CKD TRANSITION AFTER ISCHEMIC REPERFUSION （Poster notice，General）
17.	2020/10/02	ENOS/NO SIGNALLING ATTENUATES GLOMERULAR INJURY IN DIABETIC MICE VIA SUPPRESSION OF INFLAMMASOME ACTIVATION （Poster notice，General）
18.	2020/10/02	ESTABLISHMENT OF A COMPREHENSIVE NATIONWIDE BIOBANK FOR KIDNEY DISEASES WITH DEEP GENETIC DATA, DETAILED CLINICAL INFORMATION AND BIOSPECIMENS （Poster notice，General）
19.	2020/10/02	EVALUATION OF THE MECHANISM OF GLOMERULAR ARTERIOLE CHANGES BY SGLT2 INHIBITION IN TYPE 2 DIABETIC RATS （Poster notice，General）
20.	2020/10/02	Inflammasome Activation Plays a Key Role on the Progression of Peritoneal Fibrosis in Mice （Poster notice，General）
21.	2020/07/08	全身性エリテマトーデスモデルマウスにおけるアダプター蛋白SH3BP2 の自己免疫現象における役割の解明（Poster notice，General）
22.	2020/06/07	Effects of sodium–glucose cotransporter 2 inhibitor, canagliflozin on glomerular hyperfiltration and oxidative stress in mice with type 2 diabetes （Speech，General）
23.	2020/06/07	EVALUATION OF GLOMERULAR HEMODYNAMIC CHANGES BY SGLT2 INHIBITION IN TYPE 2 DIABETIC RATS USING IN VIVO IMAGING TECHNIQUES （Speech，General）
24.	2020/02/15	Zinc deficiency is a risk factor for chronic kidney disease progression （Speech，General）
25.	2019/11/10	The role of adopter protein SH3BP2 in a murine systemic lupus erythematosus model （Poster notice，General）
26.	2019/11/09	Development of an Exhaustive-Risk-Prediction System Using Deep Learning and Different Patterns of Diabetic Kidney Disease Progression Based on Patient Characteristics （Poster notice，General）
27.	2019/11/09	Endothelial Nitric Oxide Synthase/Nitric Oxide Pathway Underlies the Mechanisms of AKI to CKD Transition via Prolonged Activation of the Wnt/β-Catenin Pathway （Poster notice，General）
28.	2019/11/08	Association of Arterial Stiffness with Kidney Function Among Adults Without CKD （Poster notice，General）
29.	2019/11/08	Clarification of the Mechanism of Acute GFR Change by SGLT2 Inhibition with In Vivo Imaging Technique （Poster notice，General）
30.	2019/11/07	Activation of the Keap1/Nrf2 Pathway Increases GFR by Increasing Glomerular Effective Filtration Area Without Affecting the Afferent/Efferent Arteriole Ratio （Poster notice，General）
31.	2019/04/17	SH3BP2 gain-of-function mutation ameliorates lupus in B6.MRL-Faslpr mice （Speech，General）
32.	2019/04/12	Bardoxolone methyl analog attenuates proteinuria-induced tubular damege by modulating mitochondrial function. （Poster notice，General）
33.	2019/04/12	Effect of uremic toxin-indoxcyl sulfate on intestinal defensin expression in renal failure mice. （Poster notice，General）
34.	2019/04/12	Evaluation of the diabetic glomerular hemodynamics by SGLT2 inhibitor empagliflozin using in vivo imaging. （Poster notice，General）
35.	2018/10/25	Endothelial Dysfunction Exacerbates Renal Tubular Cell Injury Through Inflammasome Activation in a Hypertensive Mouse Model （Poster notice，General）
36.	2018/10/25	Nrf2 Activator, RTAdh404, Attenuates Tubular Injury via Eliminating Mitochondrial ROS in Proteinuria Induced Renal Failure Mice （Poster notice，General）
37.	2018/06/23	Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice Using In Vivo Imaging. （Speech，General）
38.	2018/05/25	EVALUATION OF THE GLOMERULAR HEMODYNAMICS BY THE SGLT2 INHIBITOR EMPAGLIFLOZIN USING IN VIVO IMAGING （Poster notice，General）
39.	2018/05/25	NRF2 ACTIVATOR, RTADH404, ATTENUATES RENAL TUBULAR INJURY VIA MITOCHONDRIAL PROTECTION IN NEPHROTIC MODEL MICE. （Poster notice，General）
40.	2018/02/22	A case of copper deficiency-induced pancytopenia with maintenance hemodialysis outpatient treated with polaprezinc . （Poster notice，General）
41.	2018/02/22	DPP4 inhibitor linagliptin ameliorates diabetic kidneydisease through the protection of glomerular endothelial function in mice. （Poster notice，General）
42.	2018/02/22	Effect of single pill-based combination therapy on variability of home blood pressure in hypertensive outpatients. （Poster notice，General）
43.	2018/02/22	eNOS -NO signaling attenuates renal fibrosis via suppression of catenin signaling. （Poster notice，General）
44.	2018/02/22	Evaluation of the glomerular hemodynamics alterations by SGLT2 inhibitor Empagliflozin using in vivo imaging. （Poster notice，General）
45.	2018/02/22	Membranous nephropathy diagnosed in the early stages of pregnancy :A case report. （Poster notice，General）
46.	2018/02/22	Non-purine selective xanthine oxidase inhibitor ameliorates glomerular endothelial injury in Ins2Akita diabetic mice. （Poster notice，General）
47.	2018/02/22	RTAdh404 attenuates renal inflammation and fibrosis via mitochondrial protection in ICGN mice. （Poster notice，General）
48.	2018/02/22	The association of microbiota alteration and intestinal barrier function in chronic renal failure mice. （Poster notice，General）
49.	2018/02/22	The eNOS/NO signaring attenuates glomerular injury in diabetic mice via suppression of inflammasome activation. （Poster notice，General）
50.	2018/02/10	Evaluation of the glomerular hemodynamics alterations by SGLT2 inhibitor Empagliflozin in diabetic mice using in vivo imaging. （Poster notice，General）
51.	2017/11/07	SH3BP2 Gain-of-Function Mutation Ameliorates Lupus in B6.MRL-Faslpr Mice （Poster notice，General）
52.	2017/11/03	Deficient of Endothelial Function Exacerbates NLRP3-Inflammasome Activation in Podocyte of Diabetic Nephropathy （Poster notice，General）
53.	2017/11/02	Evaluation of the Reno-Protective Effects of Empagliflozin in Diabetic Nephropathy Using In Vivo Imaging （Poster notice，General）
54.	2017/09/15	DPP4 inhibitor reduces urinary albumin excretion through the protection of glomerular endothelial function （Speech，General）
55.	2017/09/15	Evaluation of the effect of empagliflozin on improving hyperfiltration in diabetic nephropathy （Speech，General）
56.	2017/06/05	ENOS/NO Signaling Attenuates Glomerular Injury in Diabetic Mice via Suppression of Inflammasome Activation. （Poster notice，General）
57.	2017/06/04	Infiltaration on M1 macrophages is Impaired but not M2,After Unilateral, Ureter Obstruction in NRF2 Deficient Mice. （Poster notice，General）
58.	2016/11/17	Nrf2 Dependent Inflmmasome Activation Contributes to Maintain M1 Macrophage but Not M2 Infiltration in Kidney Disease Model . （Poster notice，General）
59.	2016/11/16	eNOS-NO Pathway Attenuates Chronic Inflammation via Nitric Oxide in Hypertensive Kidney Disease. （Poster notice，General）
60.	2016/09/27	Activation of Endothelial NAD(P)H Oxidase Accelerates Early Glomerular Injury in Diabetic Mice. （Poster notice，General）
61.	2016/09/27	Feasibility of Fluorescence Energy Transfer System for Imaging the Renoprotective Effects of Aliskiren in Diabetic Mice. （Poster notice，General）
62.	2016/09/26	Cyclic GMP Dependent Protein Kinase-AKT Pathway is Essential for Compensatory Renal Hypertrophy and Maintenance Renal Function After Unilateral Nephrectomy. （Poster notice，General）
63.	2016/09/26	Endothelial Cells Regulate Inflammasome Activation Through Nitric Oxde in Hypertensive Kidney Disease. （Poster notice，General）
64.	2016/09/26	Hypertension Promotes Islet Morphological Changes with Vascular Injury on Prediabetic Status in SHR-SP Rats. （Poster notice，General）
65.	2016/09/26	Possible Implication of Xanthine Oxidase Activation on the Pathogenesis Diabetic Nephropathy. （Poster notice，General）
66.	2016/09/26	Renal Denervation Protects Renal Function by Suppressing NAD(P)H Oxidase Activity in Dahl Salt-Sensitive Rats. （Poster notice，General）
67.	2016/09/19	Renoprotective Effect of 5-Aminolevulinic Acid in Rhabdomyolysis-Induced Acute Kidney Injury （Speech，General）
68.	2016/09/18	Effects of Lanthanum Carbonate on Intestinal Bacterial Flora and Intestinal Barrier Function in Chronic Renal Failure Mice （Poster notice，General）
69.	2016/02/27	Effects of Lanthanum Carbonate on Intestinal Bacterial Flora and Intestinal Barrier Function in Chronic Renal Failure Mice （Speech，General）
70.	2015/11/06	Effects of Lanthanum Carbonate on Intestinal Bacterial Flora in Chronic Renal Failure Mice. （Poster notice，General）
71.	2015/11/05	Possible Implication of Xanthine Oxidase Activation on the Pathogenesis Diabetic Nephropathy. （Poster notice，General）
72.	2015/09/25	Possible implication of xanthine oxidase activation on the pathogenesis diabetic nephropathy. （Poster notice，General）
73.	2015/09/25	Visualization of in vivo renin activity and its application to study the pathogenetic mechanisms of diabetic nephropathy （Poster notice，General）
74.	2012/11/02	Klotho Attenuates Inflammation of Adipose Tissue and Development of Insulin Resistance in High-Fat Induced Obese Mice. （Poster notice，General）
75.	2012/11/02	Stimulation of Soluble Guanylate Cyclase Attenuates Epithelial-Mesenchymal Transition of the Peritoneal Membrane and Prevent the Development of Peritoneal Fibrosis. （Speech，General）
76.	2012/07/20	eNOS-sGC pathway suppresses renal fibrosis via interruption of the Wnt-beta-catenin pathway in UUO mice. （Poster notice，General）
77.	2012/05/25	Endothelial Cell Interacted with Podocyte and Mesangial Cells Via NAD(P)H Oxidase. （Poster notice，General）
78.	2012/05/25	Endothelial Dysfunction promotes the Transition from Compensatory Renal Hypertrophy to Kidney Injury after Unilateral Neophrectomy in Mice. （Poster notice）
79.	2012/05/25	Preservation of Endothelial GTP Cyclohydrolase I Activity and Improvement of Renal Nitric Oxide Availability Prevent the Development of Diabetic Nephropathy （Poster notice，General）
80.	2011/11/12	Low-Dose Erythropoietin Increases Superoxide Production in Normal Rat Aorta and Endothelial Cells （Poster notice，General）
81.	2011/11/11	Implications of Oxidative Stress Derived from Endothelial NAD(P)H Oxdase in the Development of Diabetic Nephropathy （Poster notice，General）
82.	2011/11/07	Implications of oxidative stress derived from endothelial NAD(P)H oxidase in the development of diabetic nephropathy （Speech，General）
83.	2011/09/22	Endothelial NAD(P)H oxidase activation enhance urinary albumin excretion and progress renal dysfunction in mouse type 1 diabetic nephropathy. （Poster notice，General）
84.	2011/07/16	Comparison of combination therapy of olmesartan plus azelnidipine or hydrochlorothiazide on renal and vascular damage in SHR/NDmcr-cp rats. （Poster notice，General）
85.	2011/04/10	Cyclic GMP Dependent Protein Kinase-Akt Pathway is Essential for Compensatory Renal Hypertrophy and Maintenance Renal Function After Unilateral Nephrectomy. （Poster notice，General）
86.	2011/04/10	Over-Expression of Endothelial GTP Cyclohydrolase-ⅠAmeliorates Mouse　Diabetic Glomerulopathy. （Poster notice，General）
87.	2010/11/19	Nitric Oxide Induces Tubular Cell Hypertrophy Via Cyclic GMP-Dependedent Protein Kinase in Rat Compensatory Renal Hypertrophy （Poster notice，General）
88.	2010/09/26	Eplerenone improved renal and vascular injuries in Zucker obese rats fed high-protein diet （Poster notice，General）
89.	2010/09/26	Nitric oxide induces tubular cell hypertrophy via cyclic GMP-dependent protein kinase in rat compensatory renal hypertrophy. （Poster notice，General）
90.	2010/06/27	Mechanisms of acute tacrolims-induced nephrotoxicity and the renoprotective effects of telmisartan （Poster notice，General）
91.	2010/06/26	Calcium channel blokers azelnidipine but not amlodipine reduce glomerular damages in Dahl salt -sansitive rats by suppression of sympathetic nerve system （Poster notice，General）
92.	2010/06/26	Establishment of new blood purification system in renal failure rats using a small dialyzer （Poster notice，General）
93.	2010/06/26	Renal denervation reduces glomerular superoxide production and protects from gromerular injury in Dahl salt-sensitive rats （Poster notice，General）
94.	2010/06/15	Renal denervation attenuates glomerular schrelosis by suppressing NAD(P)H oxidase activity in Dahl salt-sensitive rats （Poster notice，General）
95.	2010/05/15	Effects of eplerenone to renal and vascular injuries in Zucker obese rats fed high-protein diet （Poster notice，General）
96.	2010/04/17	ARB/CCB combination therapy suppressed oxidative stress compared with ARB/HCTZ combination therapy in glomeruli and aorta of metabolic syndrome model rats （Poster notice，General）
97.	2010/04/17	Glomerular endothelial glycocalyx was decreases by reactive oxygen species in Zucker obese fatty rat （Poster notice，General）
98.	2010/04/17	Klotho overexpression attenuates renal fibrosis after unilateral obstruction by Wnt signaling inhibition （Speech，Special/Invited Lecture）
99.	2010/04/16	Renal denervation protects from glomerular injyury by suppressing NAD(P)H oxidase activity in Dahl salt-sensitive rats （Poster notice，General）
100.	2010/03/05	Deterioration of Glomerular Endothelial Glycocalyx Induced by Heparanase is Imvolved in Cardio-Renal Interaction （Poster notice，General）
101.	2009/10/31	Renal Denervation Protects Renal Function by Suppressing NAD(P)H Oxidase Activity in Dahl Salt-Sensitive Rats （Poster notice，General）
102.	2009/10/30	Azelnidipine Prevents Renal Dysfunction by Suppression of Sympathetic Nerve System in Dahl Salt-Sensitive Rats （Poster notice，General）
103.	2009/10/29	Alpha-Klotho Attenuates Renal Fibrosis after Unilateral Ureteral Obstruction through Inhibition of Wnt Signaling （Poster notice，General）
104.	2009/10/29	Comparison of the Renal and Vascular Protective Effects of Olmesartan/Azelnidipine with Olmesartan/Hydrochlorothiazide Combination Therapy in Metabolic Syndrome Model Rats （Poster notice，General）
105.	2009/10/29	Overexpression of Klotho Protein Inhibits Uninephrectmy Induced Compensatory renal Hypertrophy by Suppressing Insulin Like Growth Factor-1 Signals （Speech，General）
106.	2009/10/29	Renoprotective Effects of Azelnidipine by Improvements of renal Microcirculation in Angiotensin ll infusion Rat. （Poster notice，General）
107.	2009/07/17	Low dose eplerenone ameliorated glomerulosclerosis and endothelial dysfunction through antioxidative stress in metabolic syndrome model rats （Poster notice）
108.	2008/11/06	Oral adsorbent AST-120 ameliorates endothelial dysfunction and alleviates oxidative stress in aorta independent of renal function in subtotally nephrectomized rats （Poster notice，General）
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